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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DOK4, RAP2C (from a repository: Sat Jul 20 18:04:48 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)44
The number (and %) of the onco-proteins14 (31.82 %)
The number (and %) of the tumor suppressors3 (6.82 %)
Total number of binary PPIs (saturation %)91 (9.62 %)
The number (and %) of affected PPIs43 (47.25 %)
The number of possible different fusions9
PPI diameter4
PPI radius2
The average degree of PPI3.500
Assortativity coefficient-0.4029
The network average Clustering coefficient0.426
The number (and %) of a zero Clustering coefficients17 (38.64 %)
The number (and %) of a zero Betweenness Centrality26 (59.09 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RAP2C,DOK4 All fusions
Proteins found in more fusions KDM1A (see 3 fusions); RCOR1 (see 2 fusions); HMG20A (see 2 fusions); AHCYL1 (see 2 fusions); PTK2 (see 3 fusions); EGFR (see 2 fusions); GSE1 (see 2 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RAP2Cparental protein80.107213.500Ras (PF00071, IPR001806, SM00173): Ras family
2 DOK4parental protein350.0441478.133IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
3 ADRB2interactor3012.6677tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 AHCYL1suppressor31.0000AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
5 AHCYL2interactor100AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
6 ANK3interactor100BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Death (PF00531, IPR000488, SM00005): Death domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
DUF3008 (PF11450, IPR021553): Protein of unknwon function (DUF3008)
DUF3439 (PF11921, IPR024592): Domain of unknown function (DUF3439)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
7 BAG3oncoprotein40.33379.900BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
8 CCM2interactor100PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
CCM2_C (PF16545, IPR032375): Cerebral cavernous malformation protein, harmonin-homology
9 CCT6Ainteractor100Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
10 CWC22interactor100CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
MA3 (PF02847, IPR003891, SM00544): MA3 domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
SOBP (PF15279, IPR026092): Sine oculis-binding protein
11 DDX39Ainteractor307.167DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
12 DOK3suppressor100IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
13 EGFRoncoprotein70.40066.167Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
14 ELAVL1oncoprotein110.244268.267RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
15 ERBB2oncoprotein41.0000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
16 GSE1oncoprotein60.9002.400CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
Plasmodium_Vir (PF05795, IPR008780): Plasmodium vivax Vir protein
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
DUF3736 (PF12540, IPR022207): Protein of unknown function (DUF3736)
AAA_11 (PF13086): AAA domain
DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228)
17 HMG20Aprotein found in more fusions70.7338.400DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
MlaC (PF05494, IPR008869): MlaC protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
18 KBTBD6interactor21.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
19 KBTBD7interactor21.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
20 KDM1Aprotein found in more fusions70.6005.333Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
21 LIMA1suppressor30.33314.333LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
22 LIX1interactor100LIX1 (PF14954, IPR029270): Limb expression 1
23 MAPRE3interactor100CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
24 MIER1oncoprotein21.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
ELM2 (PF01448, IPR000949): ELM2 domain
HpaP (PF09483, IPR013390): Type III secretion protein (HpaP)
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein
25 OLIG1interactor100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
26 OPRD1interactor40.33361.3337tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
27 OPRK1interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
28 OPRM1interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF4231 (PF14015, IPR025325): Protein of unknown function (DUF4231)
DMRT-like (PF15791, IPR031577): Doublesex-and mab-3-related transcription factor C1 and C2
29 PBKinteractor100Pkinase (PF00069, IPR000719): Protein kinase domain
30 PHKA2interactor21.0000Glyco_hydro_15 (PF00723, IPR011613): Glycosyl hydrolases family 15
31 PHKBinteractor21.0000Glyco_hydro_15 (PF00723, IPR011613): Glycosyl hydrolases family 15
32 PHKG2interactor30.6671.000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
33 PTK2protein found in more fusions70.40073.167FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
34 RAB1Aoncoprotein50.40018.833Ras (PF00071, IPR001806, SM00173): Ras family
35 RAB1Boncoprotein30.6674.333Ras (PF00071, IPR001806, SM00173): Ras family
36 RBP7interactor100Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
37 RCOR1protein found in more fusions41.0000DivIC (PF04977, IPR007060): Septum formation initiator
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
FAM76 (PF16046, IPR032017): FAM76 protein
38 RCOR3interactor50.9002.400ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_DNA-bind_7 (PF15963): Myb DNA-binding like
39 REToncoprotein41.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
40 RHOUinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
41 RPS10interactor100S10_plectin (PF03501, IPR005326): Plectin/S10 domain
42 SMARCAD1interactor21.0000CUE (PF02845, IPR003892, SM00546): CUE domain
Pox_D5 (PF03288, IPR004968): Poxvirus D5 protein-like
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
43 STAT2oncoprotein30.6670.667SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT2_C (PF12188, IPR022756): Signal transducer and activator of transcription 2 C terminal
44 SUPT5Hinteractor100KOW (PF00467, IPR005824, SM00739): KOW motif
Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)

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