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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)87
The number (and %) of the onco-proteins12 (13.79 %)
The number (and %) of the tumor suppressors8 (9.20 %)
Total number of binary PPIs (saturation %)422 (11.28 %)
The number (and %) of affected PPIs87 (20.62 %)
The number of possible different fusions11
PPI diameter4
PPI radius2
The average degree of PPI9.172
Assortativity coefficient-0.2639
The network average Clustering coefficient0.543
The number (and %) of a zero Clustering coefficients13 (14.94 %)
The number (and %) of a zero Betweenness Centrality26 (29.89 %)

ACTIVE INTERACTORS


List of the fusions
PPI for parental proteins: EXOSC8,SUPT20H All fusions
Proteins found in more fusions STAT3 (see 2 fusions); EXOSC6 (see 1 fusions); MAPK1 (see 2 fusions); ATXN1 (see 3 fusions); UBC (see 7 fusions); RPA1 (see 1 fusions); CRMP1 (see 1 fusions); MAPK14 (see 1 fusions); VHL (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient		 Betweenness
Centrality		 Domains (Pfam, InterPro, SMART): description
1 EXOSC8parental protein650.1114030.505RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
2 SUPT20Hparental protein220.264540.658Rubella_E2 (PF05749, IPR008821): Rubella membrane glycoprotein E2
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
Spt20 (PF12090, IPR021950): Spt20 family
UL73_N (PF12522, IPR021003): Cytomegalovirus glycoprotein N terminal
3 AENinteractor100RNase_T (PF00929, IPR013520): Exonuclease
4 AICDAinteractor150.67075.781APOBEC_N (PF08210, IPR013158): APOBEC-like N-terminal domain
5 ATF2oncoprotein40.33353.679bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
6 ATG9Ainteractor2015.077APG9 (PF04109, IPR007241): Autophagy protein Apg9
PRRSV_2b (PF07069, IPR009775): Porcine reproductive and respiratory syndrome virus 2b
7 ATXN1protein found in more fusions40.33317.648AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
8 ATXN7L3interactor110.80034.751SCA7 (PF08313, IPR013243): SCA7, zinc-binding domain
Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
9 C1Dinteractor61.0000Sas10_Utp3 (PF04000, IPR007146): Sas10/Utp3/C1D family
10 COL23A1interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
11 COX5Ainteractor100COX5A (PF02284, IPR003204): Cytochrome c oxidase subunit Va
12 CRMP1protein found in more fusions31.0000Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family
13 CWC22interactor21.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
MA3 (PF02847, IPR003891, SM00544): MA3 domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
SOBP (PF15279, IPR026092): Sine oculis-binding protein
14 DIS3interactor110.9451.092RNB (PF00773, SM00955): RNB domain
rve (PF00665, IPR001584): Integrase core domain
PIN_4 (PF13638, IPR002716): PIN domain
Rrp44_CSD1 (PF17216): Rrp44-like cold shock domain
Rrp44_S1 (PF17215): S1 domain
15 DIS3Linteractor120.9241.617RNB (PF00773, SM00955): RNB domain
Rrp44_CSD1 (PF17216): Rrp44-like cold shock domain
Rrp44_S1 (PF17215): S1 domain
16 DUSP23interactor21.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family
PTPlike_phytase (PF14566): Inositol hexakisphosphate
17 EXOSC1interactor210.55774.394EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4
ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
18 EXOSC10interactor240.50779.219DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease
HRDC (PF00570, IPR002121, SM00341): HRDC domain
PMC2NT (PF08066, IPR012588): PMC2NT (NUC016) domain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
19 EXOSC2interactor190.53861.623EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4
ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
KH_6 (PF15985, IPR004088): KH domain
20 EXOSC3interactor210.61642.626KH_6 (PF15985, IPR004088): KH domain
21 EXOSC4interactor190.69352.393RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
22 EXOSC5interactor180.68040.345RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
23 EXOSC6protein found in more fusions220.53367.366RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
24 EXOSC7interactor240.493189.441RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
25 EXOSC9interactor160.7678.417RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
26 FAM90A1interactor100zf-CCHC_6 (PF15288): Zinc knuckle
27 FHOD1interactor200Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
28 FOXN3interactor100LAP1C (PF05609, IPR008662): Lamina-associated polypeptide 1C (LAP1C)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
29 FRG1interactor30.33320.840DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
FRG1 (PF06229, IPR010414): FRG1-like domain
DUF2235 (PF09994, IPR018712): Uncharacterized alpha/beta hydrolase domain (DUF2235)
30 HBS1Linteractor91.0000HBS1_N (PF08938, IPR015033): HBS1 N-terminus
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
31 HECW2interactor90.179151.085C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
32 HIST3H3interactor71.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
33 IFI16suppressor110.69118.318HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
34 KAT2Ainteractor130.74235.515Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
35 KPNA1interactor50.30052.895Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
36 LSM1interactor31.0000LSM (PF01423, IPR001163): LSM domain
37 LSM7interactor21.0000LSM (PF01423, IPR001163): LSM domain
38 MAPK1oncoprotein70.26744.201Pkinase (PF00069, IPR000719): Protein kinase domain
39 MAPK14oncoprotein50.50018.232Pkinase (PF00069, IPR000719): Protein kinase domain
40 MDC1suppressor80.57115.551FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
41 MED20interactor31.0000Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
42 MED23interactor50.400185.922Med23 (PF11573, IPR021629): Mediator complex subunit 23
43 MED4interactor100.333144.498Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
44 METTL22interactor31.0000Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
45 MKRN1interactor30.6679.881Opy2 (PF09463, IPR018571): Opy2 protein
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
CD52 (PF15116, IPR026643): CAMPATH-1 antigen
MKRN1_C (PF15815, IPR031644): E3 ubiquitin-protein ligase makorin-1, C-terminal
Torus (PF16131, IPR032297): Torus domain
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
46 MORN4interactor100MORN (PF02493, IPR003409, SM00698): MORN repeat
47 MOV10interactor120.409124.748AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
48 MPHOSPH6interactor110.87319.700MPP6 (PF10175, IPR019324): M-phase phosphoprotein 6
49 MYLK4interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
50 NXF1interactor140.244215.454NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
51 OTUD4interactor30.6671.667OTU (PF02338, IPR003323): OTU-like cysteine protease
Presenilin (PF01080, IPR001108): Presenilin
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
52 PLAC1interactor31.0000Paired_CXXCH_1 (PF09699, IPR010177): Doubled CXXCH motif (Paired_CXXCH_1)
53 PXNoncoprotein40.33325.918LIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
54 RASSF1suppressor200RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
55 RBM7interactor100.8672.319RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
56 RELoncoprotein60.267219.096RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
57 RPA1suppressor190.41297.716Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
58 RPA2oncoprotein180.392147.038RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
59 RPA3interactor170.45044.224Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
60 SGF29interactor120.75857.608DUF1325 (PF07039, IPR010750): SGF29 tudor-like domain
Filament (PF00038, IPR001664): Intermediate filament protein
61 SKIV2L2interactor190.520189.468DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DSHCT (PF08148, IPR012961, SM01142): DSHCT (NUC185) domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
rRNA_proc-arch (PF13234, IPR025696): rRNA-processing arch domain
62 SNRPBinteractor60.7333.000LSM (PF01423, IPR001163): LSM domain
63 SNRPCinteractor40.5002.559zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
64 STAT3suppressor70.33339.914SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
65 SUPT3Hinteractor120.83328.600TFIID-18kDa (PF02269, IPR003195): Transcription initiation factor IID, 18kD subunit
DUF4093 (PF13331, IPR025156): Domain of unknown function (DUF4093)
66 TADA1interactor130.73170.624SAGA-Tad1 (PF12767, IPR024738): Transcriptional regulator of RNA polII, SAGA, subunit
67 TADA2Binteractor100.8229.622SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
68 TADA3interactor130.71849.151GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF
Ada3 (PF10198, IPR019340): Histone acetyltransferases subunit 3
69 TAF10interactor130.705157.126TFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunit
70 TCEA2interactor21.0000Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
DUF4423 (PF14394, IPR025537): Domain of unknown function (DUF4423)
71 TFAP4oncoprotein31.0000DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
72 TMPOinteractor41.0000LEM (PF03020, IPR003887, SM00540): LEM domain
Thymopoietin (PF08198, IPR013146): Thymopoietin protein
LAP2alpha (PF11560, IPR021623): Lamina-associated polypeptide 2 alpha
73 TP53suppressor230.203951.008DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
74 TRRAPinteractor130.66787.159BALF1 (PF06861, IPR010677): BALF1 protein
BP28CT (PF08146, IPR012954, SM01036): BP28CT (NUC211) domain
DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
CLASP_N (PF12348, IPR024395): CLASP N terminal
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
ACDC (PF14733, IPR028078): AP2-coincident C-terminal
75 TXNDC17interactor100DUF953 (PF06110, IPR010357): Eukaryotic protein of unknown function (DUF953)
Glutaredoxin (PF00462, IPR002109): Glutaredoxin
76 TXNDC9interactor30.6670.733Thioredoxin (PF00085, IPR013766): Thioredoxin
DUF3619 (PF12279, IPR022064): Protein of unknown function (DUF3619)
77 UBCprotein found in more fusions120.40096.200ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
78 UBQLN4interactor50.33329.077CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
79 UPF2interactor120.58215.846DDHD (PF02862, IPR004177, SM01127): DDHD domain
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
Upf2 (PF04050, IPR007193): Up-frameshift suppressor 2
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
SUFU_C (PF12470, IPR024314): Suppressor of Fused Gli/Ci N terminal binding domain
80 USP22interactor130.60397.551UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
DUF2769 (PF10967, IPR020075): Protein of unknown function (DUF2769)
81 USP6oncoprotein2071.277RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
82 VHLsuppressor50.8331.578Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain
83 WDR92interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Itfg2 (PF15907, IPR031793): Integrin-alpha FG-GAP repeat-containing protein 2
84 XRN1interactor130.48766.345XRN_N (PF03159, IPR004859): XRN 5'-3' exonuclease N-terminus
85 XRN2interactor100.51158.401XRN_N (PF03159, IPR004859): XRN 5'-3' exonuclease N-terminus
86 ZCCHC8interactor90.6399.700Herpes_BLRF2 (PF05812, IPR008642): Herpesvirus BLRF2 protein
PSP (PF04046, IPR006568, SM00581): PSP
zf-CCHC (PF00098, IPR001878): Zinc knuckle
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
87 ZFP36suppressor41.0000zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)

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