Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins EXOSC8, SUPT20H (from a repository: Mon Dec 23 01:10:00 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)87
The number (and %) of the onco-proteins12 (13.79 %)
The number (and %) of the tumor suppressors8 (9.20 %)
Total number of binary PPIs (saturation %)422 (11.28 %)
The number (and %) of affected PPIs87 (20.62 %)
The number of possible different fusions11
PPI diameter4
PPI radius2
The average degree of PPI9.172
Assortativity coefficient-0.2639
The network average Clustering coefficient0.543
The number (and %) of a zero Clustering coefficients13 (14.94 %)
The number (and %) of a zero Betweenness Centrality26 (29.89 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: EXOSC8,SUPT20H All fusions
Proteins found in more fusions STAT3 (see 2 fusions); EXOSC6 (see 1 fusions); MAPK1 (see 2 fusions); ATXN1 (see 3 fusions); UBC (see 7 fusions); RPA1 (see 1 fusions); CRMP1 (see 1 fusions); MAPK14 (see 1 fusions); VHL (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 EXOSC8parental protein650.1114030.505RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
2 SUPT20Hparental protein220.264540.658Rubella_E2 (PF05749, IPR008821): Rubella membrane glycoprotein E2
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
Spt20 (PF12090, IPR021950): Spt20 family
UL73_N (PF12522, IPR021003): Cytomegalovirus glycoprotein N terminal
3 AENinteractor100RNase_T (PF00929, IPR013520): Exonuclease
4 AICDAinteractor150.67075.781APOBEC_N (PF08210, IPR013158): APOBEC-like N-terminal domain
5 ATF2oncoprotein40.33353.679bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
6 ATG9Ainteractor2015.077APG9 (PF04109, IPR007241): Autophagy protein Apg9
PRRSV_2b (PF07069, IPR009775): Porcine reproductive and respiratory syndrome virus 2b
7 ATXN1protein found in more fusions40.33317.648AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
8 ATXN7L3interactor110.80034.751SCA7 (PF08313, IPR013243): SCA7, zinc-binding domain
Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
9 C1Dinteractor61.0000Sas10_Utp3 (PF04000, IPR007146): Sas10/Utp3/C1D family
10 COL23A1interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
11 COX5Ainteractor100COX5A (PF02284, IPR003204): Cytochrome c oxidase subunit Va
12 CRMP1protein found in more fusions31.0000Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family
13 CWC22interactor21.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
MA3 (PF02847, IPR003891, SM00544): MA3 domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
SOBP (PF15279, IPR026092): Sine oculis-binding protein
14 DIS3interactor110.9451.092RNB (PF00773, SM00955): RNB domain
rve (PF00665, IPR001584): Integrase core domain
PIN_4 (PF13638, IPR002716): PIN domain
Rrp44_CSD1 (PF17216): Rrp44-like cold shock domain
Rrp44_S1 (PF17215): S1 domain
15 DIS3Linteractor120.9241.617RNB (PF00773, SM00955): RNB domain
Rrp44_CSD1 (PF17216): Rrp44-like cold shock domain
Rrp44_S1 (PF17215): S1 domain
16 DUSP23interactor21.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family
PTPlike_phytase (PF14566): Inositol hexakisphosphate
17 EXOSC1interactor210.55774.394EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4
ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
18 EXOSC10interactor240.50779.219DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease
HRDC (PF00570, IPR002121, SM00341): HRDC domain
PMC2NT (PF08066, IPR012588): PMC2NT (NUC016) domain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
19 EXOSC2interactor190.53861.623EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4
ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
KH_6 (PF15985, IPR004088): KH domain
20 EXOSC3interactor210.61642.626KH_6 (PF15985, IPR004088): KH domain
21 EXOSC4interactor190.69352.393RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
22 EXOSC5interactor180.68040.345RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
23 EXOSC6protein found in more fusions220.53367.366RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
24 EXOSC7interactor240.493189.441RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
25 EXOSC9interactor160.7678.417RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
26 FAM90A1interactor100zf-CCHC_6 (PF15288): Zinc knuckle
27 FHOD1interactor200Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
28 FOXN3interactor100LAP1C (PF05609, IPR008662): Lamina-associated polypeptide 1C (LAP1C)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
29 FRG1interactor30.33320.840DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
FRG1 (PF06229, IPR010414): FRG1-like domain
DUF2235 (PF09994, IPR018712): Uncharacterized alpha/beta hydrolase domain (DUF2235)
30 HBS1Linteractor91.0000HBS1_N (PF08938, IPR015033): HBS1 N-terminus
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
31 HECW2interactor90.179151.085C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
32 HIST3H3interactor71.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
33 IFI16suppressor110.69118.318HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
34 KAT2Ainteractor130.74235.515Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
35 KPNA1interactor50.30052.895Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
36 LSM1interactor31.0000LSM (PF01423, IPR001163): LSM domain
37 LSM7interactor21.0000LSM (PF01423, IPR001163): LSM domain
38 MAPK1oncoprotein70.26744.201Pkinase (PF00069, IPR000719): Protein kinase domain
39 MAPK14oncoprotein50.50018.232Pkinase (PF00069, IPR000719): Protein kinase domain
40 MDC1suppressor80.57115.551FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
41 MED20interactor31.0000Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
42 MED23interactor50.400185.922Med23 (PF11573, IPR021629): Mediator complex subunit 23
43 MED4interactor100.333144.498Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
44 METTL22interactor31.0000Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
45 MKRN1interactor30.6679.881Opy2 (PF09463, IPR018571): Opy2 protein
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
CD52 (PF15116, IPR026643): CAMPATH-1 antigen
MKRN1_C (PF15815, IPR031644): E3 ubiquitin-protein ligase makorin-1, C-terminal
Torus (PF16131, IPR032297): Torus domain
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
46 MORN4interactor100MORN (PF02493, IPR003409, SM00698): MORN repeat
47 MOV10interactor120.409124.748AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
48 MPHOSPH6interactor110.87319.700MPP6 (PF10175, IPR019324): M-phase phosphoprotein 6
49 MYLK4interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
50 NXF1interactor140.244215.454NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
51 OTUD4interactor30.6671.667OTU (PF02338, IPR003323): OTU-like cysteine protease
Presenilin (PF01080, IPR001108): Presenilin
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
52 PLAC1interactor31.0000Paired_CXXCH_1 (PF09699, IPR010177): Doubled CXXCH motif (Paired_CXXCH_1)
53 PXNoncoprotein40.33325.918LIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
54 RASSF1suppressor200RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
55 RBM7interactor100.8672.319RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
56 RELoncoprotein60.267219.096RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
57 RPA1suppressor190.41297.716Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
58 RPA2oncoprotein180.392147.038RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
59 RPA3interactor170.45044.224Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
60 SGF29interactor120.75857.608DUF1325 (PF07039, IPR010750): SGF29 tudor-like domain
Filament (PF00038, IPR001664): Intermediate filament protein
61 SKIV2L2interactor190.520189.468DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DSHCT (PF08148, IPR012961, SM01142): DSHCT (NUC185) domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
rRNA_proc-arch (PF13234, IPR025696): rRNA-processing arch domain
62 SNRPBinteractor60.7333.000LSM (PF01423, IPR001163): LSM domain
63 SNRPCinteractor40.5002.559zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
64 STAT3suppressor70.33339.914SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
65 SUPT3Hinteractor120.83328.600TFIID-18kDa (PF02269, IPR003195): Transcription initiation factor IID, 18kD subunit
DUF4093 (PF13331, IPR025156): Domain of unknown function (DUF4093)
66 TADA1interactor130.73170.624SAGA-Tad1 (PF12767, IPR024738): Transcriptional regulator of RNA polII, SAGA, subunit
67 TADA2Binteractor100.8229.622SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
68 TADA3interactor130.71849.151GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF
Ada3 (PF10198, IPR019340): Histone acetyltransferases subunit 3
69 TAF10interactor130.705157.126TFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunit
70 TCEA2interactor21.0000Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
DUF4423 (PF14394, IPR025537): Domain of unknown function (DUF4423)
71 TFAP4oncoprotein31.0000DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
72 TMPOinteractor41.0000LEM (PF03020, IPR003887, SM00540): LEM domain
Thymopoietin (PF08198, IPR013146): Thymopoietin protein
LAP2alpha (PF11560, IPR021623): Lamina-associated polypeptide 2 alpha
73 TP53suppressor230.203951.008DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
74 TRRAPinteractor130.66787.159BALF1 (PF06861, IPR010677): BALF1 protein
BP28CT (PF08146, IPR012954, SM01036): BP28CT (NUC211) domain
DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
CLASP_N (PF12348, IPR024395): CLASP N terminal
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
ACDC (PF14733, IPR028078): AP2-coincident C-terminal
75 TXNDC17interactor100DUF953 (PF06110, IPR010357): Eukaryotic protein of unknown function (DUF953)
Glutaredoxin (PF00462, IPR002109): Glutaredoxin
76 TXNDC9interactor30.6670.733Thioredoxin (PF00085, IPR013766): Thioredoxin
DUF3619 (PF12279, IPR022064): Protein of unknown function (DUF3619)
77 UBCprotein found in more fusions120.40096.200ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
78 UBQLN4interactor50.33329.077CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
79 UPF2interactor120.58215.846DDHD (PF02862, IPR004177, SM01127): DDHD domain
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
Upf2 (PF04050, IPR007193): Up-frameshift suppressor 2
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
SUFU_C (PF12470, IPR024314): Suppressor of Fused Gli/Ci N terminal binding domain
80 USP22interactor130.60397.551UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
DUF2769 (PF10967, IPR020075): Protein of unknown function (DUF2769)
81 USP6oncoprotein2071.277RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
82 VHLsuppressor50.8331.578Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain
83 WDR92interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Itfg2 (PF15907, IPR031793): Integrin-alpha FG-GAP repeat-containing protein 2
84 XRN1interactor130.48766.345XRN_N (PF03159, IPR004859): XRN 5'-3' exonuclease N-terminus
85 XRN2interactor100.51158.401XRN_N (PF03159, IPR004859): XRN 5'-3' exonuclease N-terminus
86 ZCCHC8interactor90.6399.700Herpes_BLRF2 (PF05812, IPR008642): Herpesvirus BLRF2 protein
PSP (PF04046, IPR006568, SM00581): PSP
zf-CCHC (PF00098, IPR001878): Zinc knuckle
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
87 ZFP36suppressor41.0000zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)

B a c k    t o    T o p ⇑