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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MAML3, ELMSAN1 (from a repository: Sun Mar 12 07:32:27 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins11 (23.91 %)
The number (and %) of the tumor suppressors8 (17.39 %)
Total number of binary PPIs (saturation %)132 (12.75 %)
The number (and %) of affected PPIs44 (33.33 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI4.870
Assortativity coefficient-0.3059
The network average Clustering coefficient0.433
The number (and %) of a zero Clustering coefficients14 (30.43 %)
The number (and %) of a zero Betweenness Centrality21 (45.65 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAML3,ELMSAN1 All fusions
Proteins found in more fusions GNAS (see 5 fusions); PFKM (see 1 fusions); EIF2AK2 (see 1 fusions); RPA1 (see 1 fusions); SH3KBP1 (see 1 fusions); USP11 (see 4 fusions); MAPK14 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAML3parental protein90.083426.400Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
Rtf2 (PF04641, IPR027799): Rtf2 RING-finger
MamL-1 (PF09596, IPR019082): MamL-1 domain
DUF2459 (PF09601, IPR011727): Protein of unknown function (DUF2459)
Kin17_mid (PF10357, IPR019447): Domain of Kin17 curved DNA-binding protein
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
SprA-related (PF12118, IPR021973): SprA-related family
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
AAA_23 (PF13476): AAA domain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
FAM70 (PF14967, IPR028014): FAM70 protein
2 ELMSAN1parental protein350.0971216.477ELM2 (PF01448, IPR000949): ELM2 domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
3 AVL9interactor100Avl9 (PF09794, IPR018307): Transport protein Avl9
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
4 CCNA2oncoprotein70.5336.479Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
5 CDK2suppressor80.5716.500Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
6 CDV3interactor21.0000TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein
CDV3 (PF15359, IPR026806): Carnitine deficiency-associated protein 3
7 CLTAinteractor50.9000.500Clathrin_lg_ch (PF01086, IPR000996): Clathrin light chain
8 CLTBinteractor41.0000Clathrin_lg_ch (PF01086, IPR000996): Clathrin light chain
9 DNTTIP1interactor100.47217.267DUF4385 (PF14328, IPR025494): Domain of unknown function (DUF4385)
10 DPM1interactor100Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
11 EIF2AK2oncoprotein40.6670.500dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Pkinase (PF00069, IPR000719): Protein kinase domain
12 ELAVL1oncoprotein130.273173.581RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
13 EPB41L3suppressor21.00004_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SAB (PF04382, IPR007477): SAB domain
14 EPB41L5interactor21.0000FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
15 ESR1suppressor80.38122.703Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
16 GNASoncoprotein31.0000G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
17 HDAC1suppressor110.311130.797FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
18 HDAC2suppressor100.44493.850Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
19 MAML1interactor31.0000MamL-1 (PF09596, IPR019082): MamL-1 domain
Kri1 (PF05178, IPR018034): KRI1-like family
PRIMA1 (PF16101): Proline-rich membrane anchor 1
20 MAPK14oncoprotein40.6670.500Pkinase (PF00069, IPR000719): Protein kinase domain
21 MYH9suppressor100.42232.721IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
22 NDUFA10interactor100dNK (PF01712, IPR002624): Deoxynucleoside kinase
23 NFX1interactor100R3H (PF01424, IPR001374, SM00393): R3H domain
XPG_I (PF00867, IPR006086, SM00484): XPG I-region
zf-NF-X1 (PF01422, IPR000967, SM00438): NF-X1 type zinc finger
24 NOTCH1suppressor60.300147.498Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
25 PDLIM5interactor100LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
26 PFKMprotein found in more fusions200PFK (PF00365, IPR000023): Phosphofructokinase
27 PPP4R2interactor100BT1 (PF03092, IPR004324): BT1 family
PPP4R2 (PF09184, IPR015267): PPP4R2
28 RAD51interactor50.6671.167Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
29 RAI1interactor100Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
30 RBPJinteractor70.333341.627BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain
LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding
TIG (PF01833, IPR002909): IPT/TIG domain
31 RPA1suppressor110.46722.534Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
32 RPA2oncoprotein70.61988.922RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
33 RPA3interactor80.6676.410Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
34 SCMH1interactor200MBT (PF02820, IPR004092, SM00561): mbt repeat
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SLED (PF12140, IPR021987): SLED domain
RBR (PF17208): RNA binding Region
35 SEC16Ainteractor50.9000.500APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
36 SH3KBP1protein found in more fusions41.0000Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
37 SUPT5Hinteractor100KOW (PF00467, IPR005824, SM00739): KOW motif
Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
38 TFAP4oncoprotein70.476138.906DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
39 TRERF1interactor40.6670.786CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
ELM2 (PF01448, IPR000949): ELM2 domain
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681)
MCRS_N (PF13325, IPR025999): N-terminal region of micro-spherule protein
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
PRIMA1 (PF16101): Proline-rich membrane anchor 1
40 TRIM27oncoprotein40.6670.500IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
41 TRIP13interactor200AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
42 USP11protein found in more fusions50.33365.868Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
43 ZBTB1interactor100BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
44 ZC3H3interactor100zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family
45 ZMYM3interactor31.0000NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
YHS (PF04945, IPR007029): YHS domain
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504)
SOBP (PF15279, IPR026092): Sine oculis-binding protein
46 ZZZ3interactor2033.008Cript (PF10235, IPR019367): Microtubule-associated protein CRIPT
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type

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