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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NOP10, VPS13B (from a repository: Thu Aug 8 02:39:47 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins3 (13.04 %)
The number (and %) of the tumor suppressors2 (8.70 %)
Total number of binary PPIs (saturation %)51 (20.16 %)
The number (and %) of affected PPIs21 (41.18 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI4.087
Assortativity coefficient-0.1198
The network average Clustering coefficient0.538
The number (and %) of a zero Clustering coefficients6 (26.09 %)
The number (and %) of a zero Betweenness Centrality12 (52.17 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: VPS13B,NOP10 All fusions
Proteins found in more fusions DKC1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 VPS13Bparental protein4012.000ATG_C (PF09333, IPR015412): Autophagy-related protein C terminal domain
SHR-BD (PF06650, IPR009543): SHR-binding domain of vacuolar-sorting associated protein 13
Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
VPS13_C (PF16909, IPR031645): Vacuolar-sorting-associated 13 protein C-terminal
2 NOP10parental protein170.191149.500Nop10p (PF04135, IPR007264): Nucleolar RNA-binding protein, Nop10p family
3 ARRB1interactor31.0000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
4 ARRB2interactor40.8330.667Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
5 BMI1oncoprotein41.0000zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
6 CDK17interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
7 CSNK1Einteractor200APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
8 DKC1oncoprotein130.28842.333DKCLD (PF08068, IPR012960, SM01136): DKCLD (NUC011) domain
PUA (PF01472, IPR002478, SM00359): PUA domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
TruB_N (PF01509, IPR002501): TruB family pseudouridylate synthase (N terminal domain)
TruB_C_2 (PF16198, IPR032819): tRNA pseudouridylate synthase B C-terminal domain
9 DNAJC7interactor100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_17 (PF13431): Tetratricopeptide repeat
10 FAM177A1interactor100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Connexin (PF00029, IPR013092, SM00037): Connexin
FAM177 (PF14774, IPR028260): FAM177 family
11 GAR1interactor40.6671.667Gar1 (PF04410, IPR007504): Gar1/Naf1 RNA binding region
12 KRASoncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
13 LIN28Ainteractor31.0000CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
zf-CCHC (PF00098, IPR001878): Zinc knuckle
zf-CCHC_6 (PF15288): Zinc knuckle
14 LIN28Binteractor21.0000CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
zf-CCHC (PF00098, IPR001878): Zinc knuckle
15 NAF1interactor50.7002.500AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
Gar1 (PF04410, IPR007504): Gar1/Naf1 RNA binding region
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
16 NHP2interactor80.46412.000Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
17 NOP56interactor60.4008.167Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
18 RPL10suppressor40.5002.000Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
19 SPACA1interactor100DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
20 SRPK3interactor30.6670.667Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Pkinase (PF00069, IPR000719): Protein kinase domain
21 SYNCRIPinteractor30.6670.500RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
22 WDR48suppressor41.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF3337 (PF11816, IPR021772): Domain of unknown function (DUF3337)
23 ZC3H3interactor21.0000zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family

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