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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRCC, ARHGAP6 (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins6 (22.22 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)60 (17.09 %)
The number (and %) of affected PPIs25 (41.67 %)
The number of possible different fusions5
PPI diameter4
PPI radius2
The average degree of PPI3.481
Assortativity coefficient-0.3476
The network average Clustering coefficient0.436
The number (and %) of a zero Clustering coefficients11 (40.74 %)
The number (and %) of a zero Betweenness Centrality14 (51.85 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions EWSR1 (see 2 fusions); EGFR (see 2 fusions); CSNK2A1 (see 1 fusions); PRPF19 (see 2 fusions); YWHAZ (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ARHGAP6parental protein100Peptidase_M6 (PF05547, IPR008757): Immune inhibitor A peptidase M6
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
2 PRCCparental protein240.076574.333PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting
3 CDC5Linteractor50.6672.000OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
4 CEP170P1interactor200NA
5 CSNK2A1oncoprotein60.7002.333Pkinase (PF00069, IPR000719): Protein kinase domain
6 EGFRoncoprotein70.6005.000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
7 EWSR1oncoprotein50.6672.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
8 HSF2interactor100HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
9 IWS1interactor31.0000DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
10 LNX1interactor3050.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
11 LRP8interactor100EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
TMEM154 (PF15102, IPR028064): TMEM154 protein family
12 LSM2interactor2096.000LSM (PF01423, IPR001163): LSM domain
13 MAD2L2interactor200HORMA (PF02301, IPR003511): HORMA domain
14 NABP2interactor100tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
15 PCK2interactor100PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
16 PIM2oncoprotein30.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
17 PPIL2interactor31.0000Rtf2 (PF04641, IPR027799): Rtf2 RING-finger
Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Ribosomal_S6 (PF01250, IPR000529): Ribosomal protein S6
zf-NOSIP (PF15906, IPR031790): Zinc-finger of nitric oxide synthase-interacting protein
18 PRPF19protein found in more fusions50.8330.667Prp19 (PF08606, IPR013915): Prp19/Pso4-like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
19 RBM10interactor60.6004.000G-patch (PF01585, IPR000467, SM00443): G-patch domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
GSIII_N (PF12437, IPR022147): Glutamine synthetase type III N terminal
G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site
zf-C2H2_4 (PF13894): C2H2-type zinc finger
DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337)
FAM176 (PF14851): FAM176 family
20 SF3A2interactor40.8330.667Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32
PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
zf-met (PF12874): Zinc-finger of C2H2 type
ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix
SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
21 SOD1interactor31.0000Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
22 SORT1interactor100Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3
23 TOE1interactor21.0000CAF1 (PF04857, IPR006941): CAF1 family ribonuclease
24 WRAP73interactor31.0000eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
IKI3 (PF04762, IPR006849): IKI3 family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2555 (PF10742, IPR019678): Protein of unknown function (DUF2555)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
25 XPO1interactor60.5336.333CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
26 YWHAZprotein found in more fusions60.6003.66714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
27 ZNF281interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
GRP (PF07172, IPR010800): Glycine rich protein family
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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