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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TYW1, KIAA0355 (from a repository: Sun Dec 16 13:58:52 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins2 (10.53 %)
The number (and %) of the tumor suppressors1 (5.26 %)
Total number of binary PPIs (saturation %)28 (16.37 %)
The number (and %) of affected PPIs17 (60.71 %)
The number of possible different fusions2
PPI diameter5
PPI radius3
The average degree of PPI2.632
Assortativity coefficient-0.4618
The network average Clustering coefficient0.358
The number (and %) of a zero Clustering coefficients9 (47.37 %)
The number (and %) of a zero Betweenness Centrality14 (73.68 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TYW1,KIAA0355 All fusions
Proteins found in more fusions LYN (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TYW1parental protein120.076229.000Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
Radical_SAM (PF04055, IPR007197): Radical SAM superfamily
Wyosine_form (PF08608, IPR013917): Wyosine base formation
2 KIAA0355parental protein50.10096.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
DUF4745 (PF15923, IPR031813): Domain of unknown function (DUF4745)
3 BTN2A1interactor100SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3169 (PF11368, IPR021509): Protein of unknown function (DUF3169)
DUF3213 (PF11491, IPR021583): Protein of unknown function (DUF3213)
Ig_3 (PF13927): Immunoglobulin domain
4 CIAO1interactor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
5 ELAVL1oncoprotein60.300145.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
6 EVA1Cinteractor100Gal_Lectin (PF02140, IPR000922): Galactose binding lectin domain
FAM176 (PF14851): FAM176 family
7 FAM189A2interactor100CD20 (PF04103, IPR007237): CD20-like family
8 FAM96Binteractor31.0000DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
9 FBXW11interactor40.66752.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
10 KRBOX4interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
11 LRRTM2interactor100LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
12 LYNoncoprotein31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
13 MKS1interactor100B9-C2 (PF07162, IPR010796): Ciliary basal body-associated, B9 protein
14 MMS19interactor31.0000DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
15 MYH13interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
16 SPINT2suppressor100Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
17 TMEM59interactor21.0000BSMAP (PF12280, IPR022065): Brain specific membrane anchored protein
18 TSPAN17interactor100Tetraspannin (PF00335, IPR018499): Tetraspanin family
19 YWHABinteractor30.66752.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor

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