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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins STEAP3, MT1X (from a repository: Wed Feb 21 00:48:46 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins4 (19.05 %)
The number (and %) of the tumor suppressors4 (19.05 %)
Total number of binary PPIs (saturation %)31 (14.76 %)
The number (and %) of affected PPIs19 (61.29 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI2.286
Assortativity coefficient-0.7983
The network average Clustering coefficient0.221
The number (and %) of a zero Clustering coefficients14 (66.67 %)
The number (and %) of a zero Betweenness Centrality17 (80.95 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MT1X,STEAP3 All fusions
Proteins found in more fusions TERF2IP (see 1 fusions); SETD7 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MT1Xparental protein50.300134.000Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
2 STEAP3parental protein140.011324.000DUF781 (PF05612, IPR008499): Mouse protein of unknown function (DUF781)
F420_oxidored (PF03807, IPR028939): NADP oxidoreductase coenzyme F420-dependent
Ferric_reduct (PF01794, IPR013130): Ferric reductase like transmembrane component
3 BADoncoprotein100Bcl-2_BAD (PF10514, IPR018868): Pro-apoptotic Bcl-2 protein, BAD
4 BNIP3Lsuppressor200BNIP3 (PF06553, IPR010548): BNIP3
5 BSGinteractor100Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
6 DLK1suppressor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
7 ELAVL1oncoprotein30150.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 ENPP6interactor100Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
9 FAM177A1interactor100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Connexin (PF00029, IPR013092, SM00037): Connexin
FAM177 (PF14774, IPR028260): FAM177 family
10 NT5Einteractor1005_nucleotid_C (PF02872, IPR008334): 5'-nucleotidase, C-terminal domain
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
11 PKMYT1interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
12 POT1interactor41.0000POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
13 SETD7protein found in more fusions200MORN (PF02493, IPR003409, SM00698): MORN repeat
MORN_2 (PF07661, IPR011652): MORN repeat variant
SET (PF00856, IPR001214, SM00317): SET domain
14 SLC39A4suppressor100Zip (PF02535, IPR003689): ZIP Zinc transporter
Class_IIIsignal (PF04021, IPR007166): Class III signal peptide
15 TERF1interactor41.0000TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
16 TERF2IPprotein found in more fusions41.0000BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
17 TEX29interactor100Connexin (PF00029, IPR013092, SM00037): Connexin
TEX29 (PF15839, IPR031685): Testis-expressed sequence 29 protein
18 TMEFF1suppressor100Kazal_2 (PF07648, IPR002350, SM00280): Kazal-type serine protease inhibitor domain
EGF_3 (PF12947, IPR024731): EGF domain
DUF3844 (PF12955, IPR024382): Domain of unknown function (DUF3844)
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
19 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
20 TMEM216interactor30.333168.000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
21 VKORC1interactor200VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family

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