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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NUP88, DARS2 (from a repository: Sat Aug 17 10:27:51 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)49
The number (and %) of the onco-proteins10 (20.41 %)
The number (and %) of the tumor suppressors6 (12.24 %)
Total number of binary PPIs (saturation %)201 (17.09 %)
The number (and %) of affected PPIs48 (23.88 %)
The number of possible different fusions7
PPI diameter4
PPI radius2
The average degree of PPI7.673
Assortativity coefficient-0.0730
The network average Clustering coefficient0.476
The number (and %) of a zero Clustering coefficients10 (20.41 %)
The number (and %) of a zero Betweenness Centrality15 (30.61 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DARS2,NUP88 All fusions
Proteins found in more fusions NUP153 (see 2 fusions); KPNB1 (see 2 fusions); CUL3 (see 1 fusions); SET (see 1 fusions); NUP214 (see 2 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DARS2parental protein190.041868.302tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
2 NUP88parental protein290.298432.300Nup88 (PF10168, IPR019321): Nuclear pore component
3 AIMP2suppressor41.0000GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
AIMP2_LysRS_bd (PF16780, IPR031889): AIMP2 lysyl-tRNA synthetase binding domain
4 ARFGEF2interactor30.6671.333DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
Sec7 (PF01369, IPR000904, SM00222): Sec7 domain
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2
5 ARHGEF26interactor100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
6 CAND1interactor120.49137.554Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
7 CIRBPoncoprotein60.7333.889RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 CNTROBinteractor100DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
FadA (PF09403, IPR018543): Adhesion protein FadA
Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
9 CPSF6interactor60.7337.253RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
10 CUL2suppressor90.72211.194Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
11 CUL3protein found in more fusions180.456112.855Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
12 DCP2interactor100DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
13 DDX19Ainteractor50.8004.449DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
14 DPYSL5interactor21.0000Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
15 EPHA8interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
16 FLNCinteractor40.5003.120CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
17 FNTAinteractor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PPTA (PF01239, IPR002088): Protein prenyltransferase alpha subunit repeat
TPR_14 (PF13428): Tetratricopeptide repeat
DUF4219 (PF13961, IPR025314): Domain of unknown function (DUF4219)
18 FOXB1interactor21.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
19 FOXH1interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
20 FOXI2interactor30.33346.541Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
21 FOXL1oncoprotein30.33346.541Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
22 FOXL2suppressor100K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
23 G3BP2interactor100.42258.503NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
24 IFI16suppressor110.8551.715HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
25 KARSinteractor50.40052.320tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
26 KPNB1protein found in more fusions180.55173.017Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
27 LOC554223interactor100NA
28 MCM3interactor60.60013.368MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
29 NARS2interactor100tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
30 NTRK1oncoprotein200.257587.670I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
31 NUP107interactor190.485144.885Nup84_Nup100 (PF04121, IPR007252): Nuclear pore protein 84 / 107
32 NUP153protein found in more fusions160.70512.411Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like
Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
33 NUP214oncoprotein180.58144.122dCache_2 (PF08269, IPR004010, SM01049): Cache domain
HisKA (PF00512, IPR003661, SM00388): His Kinase A (phospho-acceptor) domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
Mustang (PF15682, IPR031394): Musculoskeletal, temporally activated-embryonic nuclear protein 1
NUP214 (PF16755): Nucleoporin or Nuclear pore complex subunit NUP214=Nup159
34 NUP35interactor90.8890.904Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif
35 NUP62interactor150.60418.489Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
36 NUP85interactor100.80012.949Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin
37 NUP98suppressor140.51683.353Nucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase
Nup96 (PF12110, IPR021967): Nuclear protein 96
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
Keratin_2_head (PF16208, IPR032444): Keratin type II head
38 NXF1interactor180.52242.759NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
39 PLAURoncoprotein100Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
40 PORinteractor21.0000FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
41 RAE1interactor110.8731.773Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
42 RBM42interactor31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
43 RNF2interactor50.6671.348zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
44 RPA2oncoprotein60.200110.176RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
45 SEH1Linteractor120.72740.576WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
46 SEToncoprotein40.3333.982NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
Nop14 (PF04147, IPR007276): Nop14-like family
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
47 SIRT7interactor90.58332.059DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
48 SUZ12suppressor70.5335.878DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
49 TERF2interactor60.10060.411Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif

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