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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PTPN2, RALGPS2 (from a repository: Wed Aug 21 04:00:42 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins7 (26.92 %)
The number (and %) of the tumor suppressors6 (23.08 %)
Total number of binary PPIs (saturation %)55 (16.92 %)
The number (and %) of affected PPIs25 (45.45 %)
The number of possible different fusions7
PPI diameter3
PPI radius2
The average degree of PPI3.385
Assortativity coefficient-0.6193
The network average Clustering coefficient0.479
The number (and %) of a zero Clustering coefficients9 (34.62 %)
The number (and %) of a zero Betweenness Centrality16 (61.54 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RALGPS2,PTPN2 All fusions
Proteins found in more fusions SFN (see 1 fusions); STAT1 (see 1 fusions); STAT3 (see 2 fusions); YWHAG (see 1 fusions); YWHAZ (see 5 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RALGPS2parental protein40.8330.667PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
2 PTPN2parental protein210.048521.400Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
3 BAG3oncoprotein60.40070.867BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
4 COL5A1interactor100COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
5 GHRoncoprotein31.0000EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
GHBP (PF12772, IPR025871): Growth hormone receptor binding
6 HSPD1suppressor100Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
7 KATNB1interactor200WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Katanin_con80 (PF13925, IPR028021): con80 domain of Katanin
8 METTL13interactor100Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
Methyltransf_23 (PF13489): Methyltransferase domain
9 PSMC1interactor40.6672.833AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
10 PSMD14interactor31.0000JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
11 PTPN6suppressor21.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
12 SFNsuppressor50.50064.23314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
13 SLC39A4suppressor100Zip (PF02535, IPR003689): ZIP Zinc transporter
Class_IIIsignal (PF04021, IPR007166): Class III signal peptide
14 SRConcoprotein41.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
15 STAT1suppressor41.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
16 STAT3suppressor60.5005.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
17 STAT6oncoprotein21.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT6_C (PF14596, IPR028187): STAT6 C-terminal
18 TCTN2interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
19 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
20 TMEM216interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
21 TRAF2interactor200MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
22 UCHL5oncoprotein50.50016.900Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
23 VARSinteractor21.0000Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
Val_tRNA-synt_C (PF10458, IPR019499): Valyl tRNA synthetase tRNA binding arm
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
24 YWHABinteractor40.8331.06714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
25 YWHAGprotein found in more fusions60.7002.40014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
26 YWHAZprotein found in more fusions70.46712.63314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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