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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TMEM14A, RALGPS2 (from a repository: Thu Aug 22 06:54:58 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins3 (27.27 %)
The number (and %) of the tumor suppressors2 (18.18 %)
Total number of binary PPIs (saturation %)21 (38.18 %)
The number (and %) of affected PPIs9 (42.86 %)
The number of possible different fusions4
PPI diameter4
PPI radius2
The average degree of PPI2.909
Assortativity coefficient-0.6614
The network average Clustering coefficient0.388
The number (and %) of a zero Clustering coefficients5 (45.45 %)
The number (and %) of a zero Betweenness Centrality5 (45.45 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RALGPS2,TMEM14A All fusions
Proteins found in more fusions SFN (see 1 fusions); YWHAG (see 1 fusions); YWHAZ (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RALGPS2parental protein40.8330.667PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
2 TMEM14Aparental protein5060.000Tmemb_14 (PF03647, IPR005349): Transmembrane proteins 14C
3 CLN8interactor100TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain
4 CREB3interactor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
5 ELAVL1oncoprotein40.33350.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
6 LXNsuppressor100Latexin (PF06907, IPR009684): Latexin
7 SFNsuppressor41.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
8 USP18interactor100TAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
9 YWHABinteractor40.66712.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
10 YWHAGprotein found in more fusions60.60024.66714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
11 YWHAZprotein found in more fusions50.8330.66714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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