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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins STX17, BIRC5 (from a repository: Thu Oct 17 13:36:15 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)47
The number (and %) of the onco-proteins17 (36.17 %)
The number (and %) of the tumor suppressors7 (14.89 %)
Total number of binary PPIs (saturation %)177 (16.37 %)
The number (and %) of affected PPIs46 (25.99 %)
The number of possible different fusions6
PPI diameter4
PPI radius3
The average degree of PPI6.638
Assortativity coefficient-0.1879
The network average Clustering coefficient0.581
The number (and %) of a zero Clustering coefficients5 (10.64 %)
The number (and %) of a zero Betweenness Centrality14 (29.79 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: BIRC5,STX17 All fusions
Proteins found in more fusions PRKDC (see 3 fusions); VPS39 (see 1 fusions); USF2 (see 1 fusions); HSP90AA1 (see 2 fusions); SNAP29 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BIRC5parental protein380.1431127.093BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
2 STX17parental protein80.42946.383Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
Gly-zipper_YMGG (PF13441, IPR027367): YMGG-like Gly-zipper
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
3 AIPsuppressor21.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
4 AURKAoncoprotein110.48926.045Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
5 AURKBinteractor130.42454.637Pkinase (PF00069, IPR000719): Protein kinase domain
6 AURKCinteractor40.8333.252Pkinase (PF00069, IPR000719): Protein kinase domain
7 BECN1suppressor70.6007.402APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
8 BIRC2oncoprotein90.7144.733BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
9 BIRC3oncoprotein90.7144.733BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
10 CASP3interactor120.47335.682Peptidase_C14 (PF00656, IPR011600): Caspase domain
11 CASP7interactor71.0000Peptidase_C14 (PF00656, IPR011600): Caspase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
12 CASP9oncoprotein61.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
13 CDCA8interactor80.6199.337Borealin (PF10512, IPR018867): Cell division cycle-associated protein 8
Nbl1_Borealin_N (PF10444, IPR018851): Nbl1 / Borealin N terminal
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
14 CDK2suppressor90.321130.519Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
15 CDK4oncoprotein21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
16 DIABLOsuppressor60.8001.000Smac_DIABLO (PF09057, IPR015142): Second Mitochondria-derived Activator of Caspases
17 ELAVL1oncoprotein150.26468.034RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
18 EVI5interactor40.6671.067bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
LMBR1 (PF04791, IPR006876): LMBR1-like membrane protein
PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
19 F2RL1interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF4064 (PF13273, IPR025273): Protein of unknown function (DUF4064)
20 FBXL7oncoprotein100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
21 H2AFXsuppressor70.52416.589Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
22 HDAC6oncoprotein90.53617.031Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
23 HIST1H2BGoncoprotein41.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
24 HIST2H3Cinteractor50.7002.333Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
25 HIST3H3interactor41.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
26 HSP90AA1oncoprotein170.242444.359HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
27 INCENPinteractor80.5368.000ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
Ctr (PF04145, IPR007274): Ctr copper transporter family
DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
INCENP_ARK-bind (PF03941, IPR005635): Inner centromere protein, ARK binding region
INCENP_N (PF12178, IPR022006): Chromosome passenger complex (CPC) protein INCENP N terminal
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
PRKCSH-like (PF12999, IPR028146): Glucosidase II beta subunit-like
28 KCNJ6interactor100IRK (PF01007, IPR016449): Inward rectifier potassium channel
29 MDC1suppressor50.9000.500FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
30 PARK2suppressor80.4768.342IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
31 PPP1CConcoprotein50.6003.644Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
32 PRKDCprotein found in more fusions100.55619.132FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
33 RANoncoprotein40.6672.578Ras (PF00071, IPR001806, SM00173): Ras family
34 SNAP29protein found in more fusions40.33391.651DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
35 STX5interactor21.0000Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Syntaxin-18_N (PF10496, IPR019529): SNARE-complex protein Syntaxin-18 N-terminus
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
Syntaxin-5_N (PF11416, IPR021538): Syntaxin-5 N-terminal, Sly1p-binding domain
36 UFD1Linteractor100UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
37 USF2protein found in more fusions200DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
38 USP9Xinteractor60.60010.667DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
39 VPS11interactor60.7336.530DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
VPS11_C (PF12451, IPR024763): Vacuolar protein sorting protein 11 C terminal
TPR_11 (PF13414, IPR011990): TPR repeat
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
40 VPS16interactor51.0000Vps16_C (PF04840, IPR006925): Vps16, C-terminal region
Vps16_N (PF04841, IPR006926): Vps16, N-terminal region
41 VPS18interactor60.733119.278Pep3_Vps18 (PF05131, IPR007810): Pep3/Vps18/deep orange family
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
42 VPS33Ainteractor51.0000Sec1 (PF00995, IPR001619): Sec1 family
43 VPS39protein found in more fusions40.33350.792CNH (PF00780, IPR001180, SM00036): CNH domain
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
44 VPS41interactor60.733119.278Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
45 XIAPinteractor90.7503.733BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
46 XPO1interactor110.382184.009CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
47 XRCC6oncoprotein70.4675.633Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain

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