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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ND4, NSUN2 (from a repository: Thu Aug 22 21:24:26 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)79
The number (and %) of the onco-proteins18 (22.78 %)
The number (and %) of the tumor suppressors11 (13.92 %)
Total number of binary PPIs (saturation %)432 (14.02 %)
The number (and %) of affected PPIs77 (17.82 %)
The number of possible different fusions15
PPI diameter5
PPI radius3
The average degree of PPI10.228
Assortativity coefficient-0.0363
The network average Clustering coefficient0.546
The number (and %) of a zero Clustering coefficients5 (6.33 %)
The number (and %) of a zero Betweenness Centrality9 (11.39 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ND4,NSUN2 All fusions
Proteins found in more fusions NDUFS3 (see 2 fusions); TSN (see 1 fusions); EGFR (see 2 fusions); APC (see 1 fusions); NPM1 (see 1 fusions); COPS5 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); GRB2 (see 1 fusions); RPA1 (see 1 fusions); RANGAP1 (see 2 fusions); CALR (see 8 fusions); UBA1 (see 2 fusions); NCL (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ND4parental protein130.295295.763NA
2 NSUN2parental protein640.1402632.264Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
3 AARSinteractor70.4296.271DHHA1 (PF02272, IPR003156): DHHA1 domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
4 ACTR2interactor220.43387.107Actin (PF00022, IPR004000, SM00268): Actin
5 ACTR3interactor170.50740.778Actin (PF00022, IPR004000, SM00268): Actin
6 APCsuppressor4032.348APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
7 ARPC2interactor140.60423.081P34-Arc (PF04045, IPR007188): Arp2/3 complex, 34 kD subunit p34-Arc
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
8 ARRB2interactor110.49113.939Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
9 ATMsuppressor70.133212.689FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
10 AURKBinteractor50.6670.955Pkinase (PF00069, IPR000719): Protein kinase domain
11 CALRoncoprotein130.51523.165Calreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
12 CALUinteractor180.45852.619EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
13 CAND1interactor140.60315.742Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
14 CCDC8interactor110.42215.305Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
15 CEP164interactor21.0000DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
WW (PF00397, IPR001202, SM00456): WW domain
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
16 COPS5protein found in more fusions140.57789.805JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
17 CSNK1Einteractor70.40054.843APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
18 CUL1suppressor140.59017.116Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
19 CUL3protein found in more fusions210.374199.252Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
20 CUL5suppressor90.8891.505Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
21 DDX49interactor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Radical_SAM (PF04055, IPR007197): Radical SAM superfamily
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
22 ECSITinteractor60.9000.286ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
23 EFL1interactor80.9292.113EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
24 EGFRoncoprotein170.317200.515Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
25 FBLinteractor170.42654.656Fibrillarin (PF01269, IPR000692): Fibrillarin
26 FGL1interactor2071.725Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
27 FUBP1oncoprotein120.455146.724DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
28 GRB2oncoprotein110.356146.603SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
29 GTF2Binteractor40.6672.000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
30 GTF2E1interactor50.5004.067DUF1980 (PF09323, IPR015402): Domain of unknown function (DUF1980)
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
TFIIE_alpha (PF02002, IPR024550): TFIIE alpha subunit
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
31 HARSinteractor70.4769.955HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
32 ITGA4interactor150.330120.092FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
33 KIF1BPinteractor120.7428.412TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
KBP_C (PF12309, IPR022083): KIF-1 binding protein C terminal
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
34 LCA5interactor21.0000IncA (PF04156, IPR007285): IncA protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Tantalus (PF15386, IPR028149): Drosophila Tantalus-like
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
35 LIG4interactor21.0000APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
36 NCLprotein found in more fusions190.45857.703DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
37 NDUFA11interactor60.9330.2867kD_coat (PF02495, IPR003411): 7kD viral coat protein
Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
38 NDUFA8interactor80.57122.064CHCH (PF06747, IPR010625): CHCH domain
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731, IPR021725): Pathogenicity locus
39 NDUFS3protein found in more fusions140.308692.790Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
40 NDUFS4interactor70.66751.312ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
41 NDUFS5interactor70.7144.643Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
42 NDUFS6interactor70.66731.144Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain
43 NKX3-1suppressor100Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
44 NPM1suppressor210.43771.278Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
45 NRDCinteractor100.50082.448Cnd2 (PF05786, IPR022816): Condensin complex subunit 2
Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
46 NTRK1oncoprotein390.219770.436I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
47 OSGEPinteractor100.7783.055Peptidase_M22 (PF00814, IPR000905): Glycoprotease family
48 PANK4interactor90.8335.258DUF89 (PF01937, IPR002791): Protein of unknown function DUF89
Fumble (PF03630, IPR004567): Fumble
49 PFDN1interactor90.44413.869Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
50 PFDN5interactor110.50918.079Prefoldin (PF02996, IPR004127): Prefoldin subunit
UPF0693 (PF16088, IPR032143): UPF0693 family
51 PMS2oncoprotein100DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
MORN_2 (PF07661, IPR011652): MORN repeat variant
MutL_C (PF08676, IPR014790, SM00853): MutL C terminal dimerisation domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
52 PNO1interactor80.46414.308KH_1 (PF00013, IPR004088, SM00322): KH domain
53 PPP1R12Ainteractor150.43837.043DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
AAA_23 (PF13476): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
GEMIN8 (PF15348): Gemini of Cajal bodies-associated protein 8
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
54 PPP2CBsuppressor30.6671.197Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
55 PUS1interactor90.6396.935PseudoU_synth_1 (PF01416, IPR020097): tRNA pseudouridine synthase
56 PUS7interactor40.6674.230R3H (PF01424, IPR001374, SM00393): R3H domain
TruD (PF01142, IPR001656): tRNA pseudouridine synthase D (TruD)
57 RANGAP1protein found in more fusions180.50045.152RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain
SDA1 (PF05285, IPR007949): SDA1
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
58 RDXinteractor50.8000.800ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
59 RPA1suppressor200.404171.453Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
60 RPL10suppressor150.40052.356Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
61 RPS27Ainteractor60.6007.264DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
62 SENP3interactor60.7338.206Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis)
Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
63 SH3GL1oncoprotein160.49541.702BAR (PF03114, IPR004148, SM00721): BAR domain
PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
64 SH3GLB1suppressor110.8002.397BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
65 SIRT7interactor140.275114.794DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
66 THBS3oncoprotein200EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
TSP_3 (PF02412, IPR003367): Thrombospondin type 3 repeat
TSP_C (PF05735, IPR008859): Thrombospondin C-terminal region
COMP (PF11598, IPR024665): Cartilage oligomeric matrix protein
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
67 THG1Linteractor100.6674.863Thg1 (PF04446, IPR024956): tRNAHis guanylyltransferase
Thg1C (PF14413, IPR025845): Thg1 C terminal domain
68 TIMMDC1interactor50.9000.286Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
69 TP53RKoncoprotein110.7275.813APH (PF01636, IPR002575): Phosphotransferase enzyme family
Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
70 TSNprotein found in more fusions41.0000Translin (PF01997, IPR002848): Translin family
71 TTLL12interactor80.5717.140TTL (PF03133, IPR004344): Tubulin-tyrosine ligase family
72 UBA1protein found in more fusions80.52412.023ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
73 UBXN7interactor60.6673.400UBX (PF00789, IPR001012, SM00166): UBX domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
74 UGGT1interactor90.47212.958Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
UDP-g_GGTase (PF06427, IPR009448): UDP-glucose:Glycoprotein Glucosyltransferase
75 USP39oncoprotein50.7002.278UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
76 VCAM1interactor130.38584.835C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
77 WDR74interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
78 XPO5suppressor120.30352.112IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
79 YES1oncoprotein30.6670.400Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
YdjC (PF04794, IPR006879): YdjC-like protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain

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