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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins C5orf42, ELP6 (from a repository: Mon May 7 06:55:45 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)30
The number (and %) of the onco-proteins5 (16.67 %)
The number (and %) of the tumor suppressors1 (3.33 %)
Total number of binary PPIs (saturation %)104 (23.91 %)
The number (and %) of affected PPIs29 (27.88 %)
The number of possible different fusions5
PPI diameter4
PPI radius2
The average degree of PPI6.067
Assortativity coefficient-0.1925
The network average Clustering coefficient0.505
The number (and %) of a zero Clustering coefficients9 (30.00 %)
The number (and %) of a zero Betweenness Centrality15 (50.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: C5orf42,ELP6 All fusions
Proteins found in more fusions PSMC5 (see 2 fusions); PSMB3 (see 1 fusions); SRPK2 (see 1 fusions); NELFB (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 C5orf42parental protein40.167110.000Joubert (PF15392, IPR028236): Joubert syndrome-associated
2 ELP6parental protein250.200557.467ELP6 (PF09807, IPR018627): Elongation complex protein 6
3 ANKRD40interactor200Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
4 CAND1interactor40.33325.667Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
5 CIAO1interactor40.8330.400WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
6 CLK1interactor31.0000PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
7 ELP4interactor50.5003.333A_deaminase_N (PF08451, IPR013659): Adenosine/AMP deaminase N-terminal
PAXNEB (PF05625, IPR008728): PAXNEB protein
8 ELP5interactor50.5003.333Elong_Iki1 (PF10483, IPR019519): Elongator subunit Iki1
9 FAM96Binteractor40.8330.400DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
10 IKBKAPinteractor80.5719.733IKI3 (PF04762, IPR006849): IKI3 family
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
MMU163 (PF17119, IPR031342): Mitochondrial protein up-regulated during meiosis
11 IWS1interactor100DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
12 MLH1suppressor100DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
13 NELFBprotein found in more fusions200COBRA1 (PF06209, IPR010405): Cofactor of BRCA1 (COBRA1)
14 PAK1oncoprotein200PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
15 PIPOXinteractor30.6670.400DAO (PF01266, IPR006076): FAD dependent oxidoreductase
16 PSMA2interactor130.74254.067Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
17 PSMA3interactor120.83624.667Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
18 PSMA4interactor101.0000Proteasome (PF00227, IPR001353): Proteasome subunit
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
19 PSMA6interactor101.0000Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
20 PSMB3protein found in more fusions111.0000Proteasome (PF00227, IPR001353): Proteasome subunit
21 PSMB5interactor110.8912.400Proteasome (PF00227, IPR001353): Proteasome subunit
22 PSMB6interactor101.0000DUF1502 (PF07397, IPR010871): Repeat of unknown function (DUF1502)
Proteasome (PF00227, IPR001353): Proteasome subunit
23 PSMB8interactor111.0000Proteasome (PF00227, IPR001353): Proteasome subunit
24 PSMC4interactor110.8912.400AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
NTPase_1 (PF03266, IPR004948): NTPase
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
AAA_16 (PF13191): AAA ATPase domain
25 PSMC5protein found in more fusions120.8912.400AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
26 SRPK2oncoprotein60.300141.333DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
27 TUBGCP4interactor100Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
28 ZBTB2interactor100BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
29 ZBTB25interactor200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
30 ZNF639interactor100CarbpepA_inh (PF02977, IPR004231): Carboxypeptidase A inhibitor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain

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