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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins BCAS3, TRPS1 (from a repository: Sun Nov 18 06:50:49 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)49
The number (and %) of the onco-proteins13 (26.53 %)
The number (and %) of the tumor suppressors14 (28.57 %)
Total number of binary PPIs (saturation %)154 (13.10 %)
The number (and %) of affected PPIs49 (31.82 %)
The number of possible different fusions9
PPI diameter4
PPI radius2
The average degree of PPI5.224
Assortativity coefficient-0.2751
The network average Clustering coefficient0.455
The number (and %) of a zero Clustering coefficients7 (14.29 %)
The number (and %) of a zero Betweenness Centrality16 (32.65 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: BCAS3,TRPS1 All fusions
Proteins found in more fusions CTBP1 (see 2 fusions); NLK (see 4 fusions); KAT2B (see 1 fusions); SMAD4 (see 2 fusions); CCND1 (see 1 fusions); OFD1 (see 5 fusions); CTBP2 (see 2 fusions); ZDHHC17 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BCAS3parental protein320.0871191.085WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
BCAS3 (PF12490, IPR022175): Breast carcinoma amplified sequence 3
2 TRPS1parental protein170.103427.060Rubredoxin (PF00301, IPR024935): Rubredoxin
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
3 ATMsuppressor40.3338.297FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
4 BAG4interactor100BAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
5 C16orf70interactor21.0000UPF0183 (PF03676, IPR005373): Uncharacterised protein family (UPF0183)
6 CCND1oncoprotein70.40046.371Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
7 CD14interactor100LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
8 CDC23interactor60.30035.235ANAPC8 (PF04049, IPR007192): Anaphase promoting complex subunit 8 / Cdc23
DUF772 (PF05598, IPR008490): Transposase domain (DUF772)
Menin (PF05053, IPR007747): Menin
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
9 CDK18oncoprotein206.867APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
10 CDK2AP1suppressor21.0000CDK2AP (PF09806, IPR019187): Cyclin-dependent kinase 2-associated protein
11 CEP128interactor60.46729.952DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
12 CEP170P1interactor200NA
13 CTBP1protein found in more fusions100.33390.6542-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
14 CTBP2protein found in more fusions50.6673.5062-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
15 DYNLL1interactor50.33331.593Dynein_light (PF01221, IPR001372): Dynein light chain type 1
16 ESR1suppressor90.42952.136Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
17 FBF1interactor60.46727.779DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
YlqD (PF11068, IPR021297): YlqD protein
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
18 FBXW7suppressor50.16763.602Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
19 FOXJ2interactor100SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
20 HDAC1suppressor130.258176.589FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
21 HIST1H3Ainteractor70.26733.097Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
22 IRF3suppressor41.0000IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
23 KAT2Bprotein found in more fusions70.33323.738Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
24 KRASoncoprotein90.28680.675Ras (PF00071, IPR001806, SM00173): Ras family
25 MAPK3oncoprotein50.33315.417Pkinase (PF00069, IPR000719): Protein kinase domain
26 MCM6interactor40.3338.067MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
YmgB (PF10798, IPR024753): Biofilm development protein YmgB/AriR
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
27 NFATC1oncoprotein50.40015.632RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
28 NLKprotein found in more fusions303.658Pkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
29 NPHP1interactor31.0000SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FAM176 (PF14851): FAM176 family
Speriolin_N (PF15058, IPR029385): Speriolin N terminus
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
30 OFD1protein found in more fusions60.60019.906APG6 (PF04111, IPR007243): Autophagy protein Apg6
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
GrpE (PF01025, IPR000740): GrpE
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372)
LisH_2 (PF16045, IPR006594): LisH
31 PALB2suppressor31.0000IncA (PF04156, IPR007285): IncA protein
PALB2_WD40 (PF16756, IPR031920): Partner and localizer of BRCA2 WD40 domain
32 PELP1interactor30.6670.952RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
NUC202 (PF08166, IPR012980): NUC202 domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
33 PHBsuppressor60.6008.806Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
34 PTPN1suppressor31.0000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
35 RNF4interactor50.6676.384Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
36 SCLT1oncoprotein31.0000DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
XhlA (PF10779, IPR019715): Haemolysin XhlA
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Imm7 (PF15585, IPR028965): Immunity protein 7
CCCAP (PF15964, IPR031887): Centrosomal colon cancer autoantigen protein family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
37 SEC16Ainteractor30.33313.867APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
38 SMAD4suppressor80.33378.090MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
39 STK11suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
40 SUMO1interactor60.40020.978Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
41 TEAD2interactor30.3339.533TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
42 TGFB1suppressor100TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
43 TP53BP1suppressor80.17961.26353-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
44 TSG101suppressor60.40028.771APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
45 UBE2Iinteractor140.231130.323UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
46 WIPI2interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
47 XPO1interactor120.27396.117CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
48 XRCC3oncoprotein21.0000Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
49 ZDHHC17protein found in more fusions31.0000zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)

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