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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ROPN1, PLXNB3 (from a repository: Mon Feb 12 06:52:47 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins5 (17.24 %)
The number (and %) of the tumor suppressors1 (3.45 %)
Total number of binary PPIs (saturation %)39 (9.61 %)
The number (and %) of affected PPIs28 (71.79 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI2.138
Assortativity coefficient-0.1938
The network average Clustering coefficient0.161
The number (and %) of a zero Clustering coefficients23 (79.31 %)
The number (and %) of a zero Betweenness Centrality24 (82.76 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions CUL7 (see 2 fusions); HNRNPUL1 (see 1 fusions); CEP57L1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ROPN1parental protein220.014693.000RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
2 PLXNB3parental protein60250.000Plexin_cytopl (PF08337, IPR013548): Plexin cytoplasmic RasGAP domain
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
Taeniidae_ag (PF05596, IPR008860): Taeniidae antigen
TIG (PF01833, IPR002909): IPT/TIG domain
3 AKAP3interactor21.0000AKAP_110 (PF05716, IPR018292, SM00807): A-kinase anchor protein 110 kDa (AKAP 110)
RII_binding_1 (PF10522, IPR018459): RII binding domain
4 AKAP7interactor21.0000AKAP7_NLS (PF10469, IPR019510): AKAP7 2'5' RNA ligase-like domain
5 ARHGEF11interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RGS-like (PF09128, IPR015212): Regulator of G protein signalling-like domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
6 BTBD3interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
PHR (PF08005, IPR012983): PHR domain
7 CEP57L1protein found in more fusions31.0000Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57
XhlA (PF10779, IPR019715): Haemolysin XhlA
YqzE (PF14038, IPR025622): YqzE-like protein
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
8 CKS1Boncoprotein200CKS (PF01111, IPR000789, SM01084): Cyclin-dependent kinase regulatory subunit
9 CNSTinteractor100Consortin_C (PF15281, IPR028129): Consortin C-terminus
10 CUL7protein found in more fusions30264.000ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
11 GNL3Linteractor100DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
12 GPKOWinteractor100KOW (PF00467, IPR005824, SM00739): KOW motif
G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site
13 HNRNPUL1protein found in more fusions30294.000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Rox3 (PF08633, IPR013942): Rox3 mediator complex subunit
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
14 KIF9interactor100Laminin_II (PF06009, IPR010307): Laminin Domain II
Mvb12 (PF09452, IPR019014): ESCRT-I subunit Mvb12
Prismane (PF03063, IPR004137): Prismane/CO dehydrogenase family
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
15 LENG1interactor21.0000Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
DUF3323 (PF11796, IPR024466): Protein of unknown function N-terminus (DUF3323)
16 LNX1interactor200PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
17 MAGI2interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
WW (PF00397, IPR001202, SM00456): WW domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
PDZ_2 (PF13180, IPR001478): PDZ domain
MAGI_u1 (PF16663): Unstructured region on MAGI
MAGI_u5 (PF16666): Unstructured region on MAGI
18 MAGI3interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
WW (PF00397, IPR001202, SM00456): WW domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
PDZ_2 (PF13180, IPR001478): PDZ domain
MAGI_u1 (PF16663): Unstructured region on MAGI
19 POLR3Cinteractor100HTH_9 (PF08221, IPR013197): RNA polymerase III subunit RPC82 helix-turn-helix domain
NIT (PF08376, IPR013587): Nitrate and nitrite sensing
RNA_pol_Rpc82 (PF05645, IPR008806): RNA polymerase III subunit RPC82
HD_4 (PF13328, IPR003607): HD domain
20 PRKAA1suppressor100Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
21 PSMA1interactor200Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
22 RTP5interactor100zf-3CxxC (PF13695, IPR027377): Zinc-binding domain
23 SDCBPinteractor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
24 SERTAD1interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
SERTA (PF06031, IPR009263): SERTA motif
25 SPA17oncoprotein30.6671.000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
26 SPOCK2interactor100SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region
Kazal_2 (PF07648, IPR002350, SM00280): Kazal-type serine protease inhibitor domain
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
27 TULP3interactor100Tub (PF01167, IPR000007): Tub family
Tub_N (PF16322, IPR005398): Tubby N-terminal
28 UBE2Winteractor200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
29 XKR3interactor100XK-related (PF09815, IPR018629): XK-related protein

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