1 |
PPEF2 | parental protein | 1 | 0 | 0 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase PPP5 (PF08321, IPR013235): PPP5 TPR repeat region Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
2 |
CASP7 | parental protein | 46 | 0.148 | 1264.236 | Peptidase_C14 (PF00656, IPR011600): Caspase domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
3 |
ARHGDIA | interactor | 8 | 0.667 | 5.202 | Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor |
4 |
BAX | suppressor | 8 | 0.810 | 1.917 | Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family |
5 |
BIRC2 | oncoprotein | 12 | 0.745 | 5.852 | BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
6 |
BIRC3 | oncoprotein | 10 | 0.833 | 2.202 | BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
7 |
BIRC5 | interactor | 7 | 1.000 | 0 | BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain |
8 |
BIRC6 | oncoprotein | 5 | 1.000 | 0 | BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain SlyX (PF04102, IPR007236): SlyX UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme BIRC6 (PF12356, IPR022103): Baculoviral IAP repeat-containing protein 6 ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain |
9 |
BIRC7 | interactor | 6 | 1.000 | 0 | BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
10 |
CALM1 | interactor | 2 | 0 | 92.000 | EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
11 |
CAPN1 | interactor | 11 | 0.582 | 17.833 | Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair |
12 |
CASP10 | interactor | 12 | 0.745 | 5.286 | DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain |
13 |
CASP2 | suppressor | 10 | 0.833 | 2.202 | CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Peptidase_C14 (PF00656, IPR011600): Caspase domain |
14 |
CASP3 | interactor | 29 | 0.220 | 276.950 | Peptidase_C14 (PF00656, IPR011600): Caspase domain |
15 |
CASP8 | suppressor | 20 | 0.374 | 64.719 | DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain |
16 |
CASP9 | oncoprotein | 15 | 0.524 | 27.100 | CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Peptidase_C14 (PF00656, IPR011600): Caspase domain |
17 |
CCT2 | interactor | 4 | 0.500 | 1.833 | Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family |
18 |
CLSPN | interactor | 2 | 1.000 | 0 | Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein Presenilin (PF01080, IPR001108): Presenilin PTS_IIB (PF02302, IPR003501): PTS system, Lactose/Cellobiose specific IIB subunit XAP5 (PF04921, IPR007005): XAP5, circadian clock regulator Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal |
19 |
CNDP2 | suppressor | 8 | 0.929 | 0.667 | Peptidase_M20 (PF01546, IPR002933): Peptidase family M20/M25/M40 |
20 |
COPS6 | interactor | 7 | 0.467 | 7.333 | DUF320 (PF03777, IPR005528): Small secreted domain (DUF320) JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function |
21 |
CRYAB | oncoprotein | 8 | 0.952 | 0.333 | Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family |
22 |
CTSA | interactor | 4 | 1.000 | 0 | Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase |
23 |
DFFA | suppressor | 3 | 1.000 | 0 | CIDE-N (PF02017, IPR003508): CIDE-N domain DFF-C (PF09033, IPR015121): DNA Fragmentation factor 45kDa, C terminal domain T2SSppdC (PF12528, IPR022204): Type II secretion prepilin peptidase dependent protein C SAPIS-gp6 (PF16722, IPR031999): Pathogenicity island protein gp6 in Staphylococcus |
24 |
EEF2 | interactor | 8 | 0.464 | 13.333 | EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II |
25 |
EIF4H | interactor | 4 | 1.000 | 0 | eIF-4B (PF06273, IPR010433): Plant specific eukaryotic initiation factor 4B RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
26 |
FBXW11 | interactor | 5 | 0.500 | 2.250 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like |
27 |
GBP2 | interactor | 8 | 0.786 | 6.000 | GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain |
28 |
GINS2 | interactor | 9 | 0.667 | 7.500 | Sld5 (PF05916, IPR021151): GINS complex protein |
29 |
GNS | interactor | 7 | 1.000 | 0 | Sulfatase (PF00884, IPR000917): Sulfatase DUF4976 (PF16347, IPR032506): Domain of unknown function (DUF4976) |
30 |
GZMB | interactor | 5 | 0.700 | 2.000 | Trypsin (PF00089, IPR001254, SM00020): Trypsin |
31 |
HSPA5 | oncoprotein | 5 | 0.667 | 1.667 | HSP70 (PF00012, IPR013126): Hsp70 protein |
32 |
MVD | interactor | 10 | 0.806 | 3.500 | GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain |
33 |
PARP1 | suppressor | 5 | 0.833 | 1.200 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region |
34 |
PEPD | interactor | 10 | 0.667 | 11.167 | AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 DUF3793 (PF12672, IPR024523): Protein of unknown function (DUF3793) |
35 |
PLA2G4B | interactor | 3 | 1.000 | 0 | C2 (PF00168, IPR000008, SM00239): C2 domain PLA2_B (PF01735, IPR002642): Lysophospholipase catalytic domain |
36 |
PTGES3 | interactor | 5 | 0.667 | 1.250 | CS (PF04969, IPR007052): CS domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
37 |
RB1 | suppressor | 6 | 0.800 | 5.200 | RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain Rb_C (PF08934, IPR015030): Rb C-terminal domain DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592) |
38 |
ROCK1 | interactor | 2 | 1.000 | 0 | FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil ZapB (PF06005, IPR009252): Cell division protein ZapB HR1 (PF02185, IPR011072, SM00742): Hr1 repeat PH (PF00169, IPR001849, SM00233): PH domain Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20 Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain Rho_Binding (PF08912, IPR015008): Rho Binding SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Lzipper-MIP1 (PF14389, IPR025757): Leucine-zipper of ternary complex factor MIP1 PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase |
39 |
RPS6KA1 | oncoprotein | 11 | 0.600 | 16.167 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
40 |
SAT1 | protein found in more fusions | 4 | 0.667 | 1.000 | Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family |
41 |
SP1 | protein found in more fusions | 7 | 0.467 | 181.500 | zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
42 |
SPTAN1 | oncoprotein | 8 | 0.464 | 11.083 | EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Tetrabrachion (PF11401, IPR021535): Tetrabrachion EF-hand_7 (PF13499, IPR011992): EF-hand domain pair E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain |
43 |
STAT1 | suppressor | 6 | 0.600 | 2.500 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain |
44 |
TERF1 | interactor | 5 | 0.500 | 2.333 | TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain |
45 |
TNFRSF1A | oncoprotein | 9 | 0.643 | 5.250 | Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region |
46 |
VCP | protein found in more fusions | 12 | 0.255 | 32.167 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944) |
47 |
VIM | suppressor | 8 | 0.524 | 12.617 | Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region |
48 |
XIAP | interactor | 15 | 0.560 | 22.650 | BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |