Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PPEF2, CASP7 (from a repository: Fri Jul 12 00:32:10 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 48 The number (and %) of the onco-proteins 12 (25.00 %) The number (and %) of the tumor suppressors 9 (18.75 %) Total number of binary PPIs (saturation %) 221 (19.59 %) The number (and %) of affected PPIs 47 (21.27 %) The number of possible different fusions 11 PPI diameter 4 PPI radius 2 The average degree of PPI 8.083 Assortativity coefficient -0.3117 The network average Clustering coefficient 0.670 The number (and %) of a zero Clustering coefficients 2 (4.17 %) The number (and %) of a zero Betweenness Centrality 11 (22.92 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PPEF2,CASP7	All fusions
Proteins found in more fusions	SAT1 (see 6 fusions); CASP7 (see 1 fusions); BIRC6 (see 1 fusions); PARP1 (see 1 fusions); VCP (see 4 fusions); CASP2 (see 3 fusions); STAT1 (see 1 fusions); VIM (see 1 fusions); SP1 (see 1 fusions); TNFRSF1A (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PPEF2	parental protein	1	0	0	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase PPP5 (PF08321, IPR013235): PPP5 TPR repeat region Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
2	CASP7	parental protein	46	0.148	1264.236	Peptidase_C14 (PF00656, IPR011600): Caspase domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
3	ARHGDIA	interactor	8	0.667	5.202	Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
4	BAX	suppressor	8	0.810	1.917	Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
5	BIRC2	oncoprotein	12	0.745	5.852	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
6	BIRC3	oncoprotein	10	0.833	2.202	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
7	BIRC5	interactor	7	1.000	0	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
8	BIRC6	oncoprotein	5	1.000	0	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain SlyX (PF04102, IPR007236): SlyX UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme BIRC6 (PF12356, IPR022103): Baculoviral IAP repeat-containing protein 6 ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
9	BIRC7	interactor	6	1.000	0	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
10	CALM1	interactor	2	0	92.000	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
11	CAPN1	interactor	11	0.582	17.833	Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
12	CASP10	interactor	12	0.745	5.286	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
13	CASP2	suppressor	10	0.833	2.202	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
14	CASP3	interactor	29	0.220	276.950	Peptidase_C14 (PF00656, IPR011600): Caspase domain
15	CASP8	suppressor	20	0.374	64.719	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
16	CASP9	oncoprotein	15	0.524	27.100	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
17	CCT2	interactor	4	0.500	1.833	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
18	CLSPN	interactor	2	1.000	0	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein Presenilin (PF01080, IPR001108): Presenilin PTS_IIB (PF02302, IPR003501): PTS system, Lactose/Cellobiose specific IIB subunit XAP5 (PF04921, IPR007005): XAP5, circadian clock regulator Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
19	CNDP2	suppressor	8	0.929	0.667	Peptidase_M20 (PF01546, IPR002933): Peptidase family M20/M25/M40
20	COPS6	interactor	7	0.467	7.333	DUF320 (PF03777, IPR005528): Small secreted domain (DUF320) JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
21	CRYAB	oncoprotein	8	0.952	0.333	Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
22	CTSA	interactor	4	1.000	0	Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
23	DFFA	suppressor	3	1.000	0	CIDE-N (PF02017, IPR003508): CIDE-N domain DFF-C (PF09033, IPR015121): DNA Fragmentation factor 45kDa, C terminal domain T2SSppdC (PF12528, IPR022204): Type II secretion prepilin peptidase dependent protein C SAPIS-gp6 (PF16722, IPR031999): Pathogenicity island protein gp6 in Staphylococcus
24	EEF2	interactor	8	0.464	13.333	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
25	EIF4H	interactor	4	1.000	0	eIF-4B (PF06273, IPR010433): Plant specific eukaryotic initiation factor 4B RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26	FBXW11	interactor	5	0.500	2.250	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
27	GBP2	interactor	8	0.786	6.000	GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
28	GINS2	interactor	9	0.667	7.500	Sld5 (PF05916, IPR021151): GINS complex protein
29	GNS	interactor	7	1.000	0	Sulfatase (PF00884, IPR000917): Sulfatase DUF4976 (PF16347, IPR032506): Domain of unknown function (DUF4976)
30	GZMB	interactor	5	0.700	2.000	Trypsin (PF00089, IPR001254, SM00020): Trypsin
31	HSPA5	oncoprotein	5	0.667	1.667	HSP70 (PF00012, IPR013126): Hsp70 protein
32	MVD	interactor	10	0.806	3.500	GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
33	PARP1	suppressor	5	0.833	1.200	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
34	PEPD	interactor	10	0.667	11.167	AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 DUF3793 (PF12672, IPR024523): Protein of unknown function (DUF3793)
35	PLA2G4B	interactor	3	1.000	0	C2 (PF00168, IPR000008, SM00239): C2 domain PLA2_B (PF01735, IPR002642): Lysophospholipase catalytic domain
36	PTGES3	interactor	5	0.667	1.250	CS (PF04969, IPR007052): CS domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
37	RB1	suppressor	6	0.800	5.200	RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain Rb_C (PF08934, IPR015030): Rb C-terminal domain DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
38	ROCK1	interactor	2	1.000	0	FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil ZapB (PF06005, IPR009252): Cell division protein ZapB HR1 (PF02185, IPR011072, SM00742): Hr1 repeat PH (PF00169, IPR001849, SM00233): PH domain Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20 Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain Rho_Binding (PF08912, IPR015008): Rho Binding SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Lzipper-MIP1 (PF14389, IPR025757): Leucine-zipper of ternary complex factor MIP1 PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
39	RPS6KA1	oncoprotein	11	0.600	16.167	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
40	SAT1	protein found in more fusions	4	0.667	1.000	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
41	SP1	protein found in more fusions	7	0.467	181.500	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
42	SPTAN1	oncoprotein	8	0.464	11.083	EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Tetrabrachion (PF11401, IPR021535): Tetrabrachion EF-hand_7 (PF13499, IPR011992): EF-hand domain pair E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
43	STAT1	suppressor	6	0.600	2.500	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
44	TERF1	interactor	5	0.500	2.333	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
45	TNFRSF1A	oncoprotein	9	0.643	5.250	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
46	VCP	protein found in more fusions	12	0.255	32.167	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
47	VIM	suppressor	8	0.524	12.617	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
48	XIAP	interactor	15	0.560	22.650	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)

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