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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PPEF2, CASP7 (from a repository: Fri Jul 12 00:32:10 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)48
The number (and %) of the onco-proteins12 (25.00 %)
The number (and %) of the tumor suppressors9 (18.75 %)
Total number of binary PPIs (saturation %)221 (19.59 %)
The number (and %) of affected PPIs47 (21.27 %)
The number of possible different fusions11
PPI diameter4
PPI radius2
The average degree of PPI8.083
Assortativity coefficient-0.3117
The network average Clustering coefficient0.670
The number (and %) of a zero Clustering coefficients2 (4.17 %)
The number (and %) of a zero Betweenness Centrality11 (22.92 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PPEF2,CASP7 All fusions
Proteins found in more fusions SAT1 (see 6 fusions); CASP7 (see 1 fusions); BIRC6 (see 1 fusions); PARP1 (see 1 fusions); VCP (see 4 fusions); CASP2 (see 3 fusions); STAT1 (see 1 fusions); VIM (see 1 fusions); SP1 (see 1 fusions); TNFRSF1A (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PPEF2parental protein100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
PPP5 (PF08321, IPR013235): PPP5 TPR repeat region
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
2 CASP7parental protein460.1481264.236Peptidase_C14 (PF00656, IPR011600): Caspase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
3 ARHGDIAinteractor80.6675.202Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
4 BAXsuppressor80.8101.917Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
5 BIRC2oncoprotein120.7455.852BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
6 BIRC3oncoprotein100.8332.202BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
7 BIRC5interactor71.0000BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
8 BIRC6oncoprotein51.0000BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
SlyX (PF04102, IPR007236): SlyX
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
BIRC6 (PF12356, IPR022103): Baculoviral IAP repeat-containing protein 6
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
9 BIRC7interactor61.0000BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
10 CALM1interactor2092.000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
11 CAPN1interactor110.58217.833Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
12 CASP10interactor120.7455.286DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
13 CASP2suppressor100.8332.202CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
14 CASP3interactor290.220276.950Peptidase_C14 (PF00656, IPR011600): Caspase domain
15 CASP8suppressor200.37464.719DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
16 CASP9oncoprotein150.52427.100CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
17 CCT2interactor40.5001.833Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
18 CLSPNinteractor21.0000Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein
Presenilin (PF01080, IPR001108): Presenilin
PTS_IIB (PF02302, IPR003501): PTS system, Lactose/Cellobiose specific IIB subunit
XAP5 (PF04921, IPR007005): XAP5, circadian clock regulator
Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
19 CNDP2suppressor80.9290.667Peptidase_M20 (PF01546, IPR002933): Peptidase family M20/M25/M40
20 COPS6interactor70.4677.333DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
21 CRYABoncoprotein80.9520.333Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
22 CTSAinteractor41.0000Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
23 DFFAsuppressor31.0000CIDE-N (PF02017, IPR003508): CIDE-N domain
DFF-C (PF09033, IPR015121): DNA Fragmentation factor 45kDa, C terminal domain
T2SSppdC (PF12528, IPR022204): Type II secretion prepilin peptidase dependent protein C
SAPIS-gp6 (PF16722, IPR031999): Pathogenicity island protein gp6 in Staphylococcus
24 EEF2interactor80.46413.333EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
25 EIF4Hinteractor41.0000eIF-4B (PF06273, IPR010433): Plant specific eukaryotic initiation factor 4B
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26 FBXW11interactor50.5002.250WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
27 GBP2interactor80.7866.000GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
28 GINS2interactor90.6677.500Sld5 (PF05916, IPR021151): GINS complex protein
29 GNSinteractor71.0000Sulfatase (PF00884, IPR000917): Sulfatase
DUF4976 (PF16347, IPR032506): Domain of unknown function (DUF4976)
30 GZMBinteractor50.7002.000Trypsin (PF00089, IPR001254, SM00020): Trypsin
31 HSPA5oncoprotein50.6671.667HSP70 (PF00012, IPR013126): Hsp70 protein
32 MVDinteractor100.8063.500GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
33 PARP1suppressor50.8331.200BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
WGR (PF05406, IPR008893, SM00773): WGR domain
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
34 PEPDinteractor100.66711.167AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
DUF3793 (PF12672, IPR024523): Protein of unknown function (DUF3793)
35 PLA2G4Binteractor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
PLA2_B (PF01735, IPR002642): Lysophospholipase catalytic domain
36 PTGES3interactor50.6671.250CS (PF04969, IPR007052): CS domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
37 RB1suppressor60.8005.200RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
38 ROCK1interactor21.0000FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil
ZapB (PF06005, IPR009252): Cell division protein ZapB
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
PH (PF00169, IPR001849, SM00233): PH domain
Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
Rho_Binding (PF08912, IPR015008): Rho Binding
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Lzipper-MIP1 (PF14389, IPR025757): Leucine-zipper of ternary complex factor MIP1
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
39 RPS6KA1oncoprotein110.60016.167Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
40 SAT1protein found in more fusions40.6671.000Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
41 SP1protein found in more fusions70.467181.500zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
42 SPTAN1oncoprotein80.46411.083EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Tetrabrachion (PF11401, IPR021535): Tetrabrachion
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
43 STAT1suppressor60.6002.500SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
44 TERF1interactor50.5002.333TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
45 TNFRSF1Aoncoprotein90.6435.250Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
46 VCPprotein found in more fusions120.25532.167AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
47 VIMsuppressor80.52412.617Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
48 XIAPinteractor150.56022.650BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)

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