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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CROT, TDRD6 (from a repository: Fri Aug 2 13:51:24 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins1 (9.09 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)14 (25.45 %)
The number (and %) of affected PPIs9 (64.29 %)
The number of possible different fusions2
PPI diameter4
PPI radius2
The average degree of PPI2.000
Assortativity coefficient-0.8364
The network average Clustering coefficient0.212
The number (and %) of a zero Clustering coefficients8 (72.73 %)
The number (and %) of a zero Betweenness Centrality8 (72.73 %)


List of the fusions

PPI for parental proteins: CROT,TDRD6 All fusions
Proteins found in more fusions USP25 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CROTparental protein7078.000Carn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
2 TDRD6parental protein21.0000TUDOR (PF00567, IPR002999, SM00333): Tudor domain
SNase (PF00565, IPR016071, SM00318): Staphylococcal nuclease homologue
3 ALBinteractor100Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
4 DSTNinteractor100Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
5 EIF2AK4interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
RWD (PF05773, IPR006575, SM00591): RWD domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
HGTP_anticodon2 (PF12745, IPR024435): Anticodon binding domain of tRNAs
tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
6 KLHDC4interactor2042.000Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
YqzE (PF14038, IPR025622): YqzE-like protein
7 PEX5interactor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
SHNi-TPR (PF10516, IPR019544): SHNi-TPR
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_15 (PF13429): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
8 TERF1interactor40.33332.000TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
9 TERF2interactor31.0000Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
10 USP25protein found in more fusions200UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UBA_4 (PF14555): UBA-like domain
11 VWA9interactor100VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain

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