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Visualization interactions

Powered by Cytoscape Web for: parental proteins RBM47, CDK14 (from a repository: Mon Jun 5 08:38:38 2017)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)22
The number (and %) of the onco-proteins5 (22.73 %)
The number (and %) of the tumor suppressors4 (18.18 %)
Total number of binary PPIs (saturation %)46 (19.91 %)
The number (and %) of affected PPIs21 (45.65 %)
The number of possible different fusions2
PPI diameter5
PPI radius3
The average degree of PPI3.545
Assortativity coefficient-0.4123
The network average Clustering coefficient0.423
The number (and %) of a zero Clustering coefficients8 (36.36 %)
The number (and %) of a zero Betweenness Centrality11 (50.00 %)


List of the fusions

PPI for parental proteins: RBM47,CDK14 All fusions
Proteins found in more fusions HSP90AA1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 RBM47parental protein50.20078.667Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
2 CDK14parental protein160.105322.333Pkinase (PF00069, IPR000719): Protein kinase domain
TruB_C_2 (PF16198, IPR032819): tRNA pseudouridylate synthase B C-terminal domain
3 ATMsuppressor40.66715.000FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
4 C1orf94interactor200DUF4688 (PF15752, IPR031496): Domain of unknown function (DUF4688)
5 CAMK1interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
Tyrosinase (PF00264, IPR002227): Common central domain of tyrosinase
6 CCND3oncoprotein41.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
7 CCNYinteractor2021.667Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
8 CDK17interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
9 CDK5oncoprotein60.8001.333Pkinase (PF00069, IPR000719): Protein kinase domain
10 CDKN1Asuppressor50.8001.333CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
11 ELAVL1oncoprotein70.40057.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12 ELL3interactor100Occludin_ELL (PF07303, IPR010844): Occludin homology domain
ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
TEX19 (PF15553, IPR029093): Testis-expressed protein 19
13 HSFY1interactor100HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
14 HSP90AA1oncoprotein60.5005.000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
15 HSP90AA5Pinteractor21.0000NA
16 ICKinteractor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
17 IGHA2interactor100ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4333 (PF14230, IPR025637): Domain of unknown function (DUF4333)
18 RB1suppressor41.0000RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
19 RBM14suppressor40.66747.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
20 RNF2interactor50.66731.000zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
21 SEPT8interactor100IMD (PF08397, IPR013606): IRSp53/MIM homology domain
Septin (PF00735, IPR000038): Septin
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
22 TOP1oncoprotein50.50088.333DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core
Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment
MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
TonB_N (PF16031): TonB N-terminal region

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