Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RBM47, APBB2 (from a repository: Mon Mar 13 15:04:44 2017)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)34
The number (and %) of the onco-proteins9 (26.47 %)
The number (and %) of the tumor suppressors2 (5.88 %)
Total number of binary PPIs (saturation %)70 (12.48 %)
The number (and %) of affected PPIs32 (45.71 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI3.588
Assortativity coefficient-0.4615
The network average Clustering coefficient0.385
The number (and %) of a zero Clustering coefficients12 (35.29 %)
The number (and %) of a zero Betweenness Centrality19 (55.88 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RBM47,APBB2 All fusions
Proteins found in more fusions GAN (see 1 fusions); APP (see 4 fusions); EGFR (see 2 fusions); GOPC (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RBM47parental protein50.200127.400Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
2 APBB2parental protein270.060791.019PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
WW (PF00397, IPR001202, SM00456): WW domain
3 AKAP1interactor21.0000TUDOR (PF00567, IPR002999, SM00333): Tudor domain
RII_binding_1 (PF10522, IPR018459): RII binding domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
4 APBB1interactor70.40014.667PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
WW (PF00397, IPR001202, SM00456): WW domain
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID)
5 APLP1interactor21.0000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
Ints3 (PF10189, IPR019333): Integrator complex subunit 3
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 APLP2interactor30.33335.631APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
ELM2 (PF01448, IPR000949): ELM2 domain
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
Usp (PF00582, IPR006016): Universal stress protein family
YL1 (PF05764, IPR008895): YL1 nuclear protein
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
7 APOL2interactor100ApoL (PF05461, IPR008405): Apolipoprotein L
8 APPprotein found in more fusions90.32183.805APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
9 ATMsuppressor40.33341.905FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
10 ATP7Ainteractor100E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Fer2_BFD (PF04324, IPR007419): BFD-like [2Fe-2S] binding domain
HMA (PF00403, IPR006121): Heavy-metal-associated domain
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
11 C1orf94interactor200DUF4688 (PF15752, IPR031496): Domain of unknown function (DUF4688)
12 CBWD1interactor21.0000cobW (PF02492, IPR003495): CobW/HypB/UreG, nucleotide-binding domain
CobW_C (PF07683, IPR011629, SM00833): Cobalamin synthesis protein cobW C-terminal domain
13 EGFRoncoprotein80.47616.833Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
14 ELAVL1oncoprotein70.13382.693RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
15 FMN2interactor100ATP-synt_B (PF00430, IPR002146): ATP synthase B/B' CF(0)
DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
AAA_23 (PF13476): AAA domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
16 GANprotein found in more fusions41.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
17 GOPConcoprotein31.0000DUF903 (PF06004, IPR010305): Bacterial protein of unknown function (DUF903)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF3209 (PF11483, IPR021577): Protein of unknown function (DUF3209)
18 HSFY1interactor100HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
19 HSPA8oncoprotein60.46783.705HSP70 (PF00012, IPR013126): Hsp70 protein
20 LDHAL6Binteractor100Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
21 MRPL1interactor30.6672.524CUB_2 (PF02408, IPR003366): CUB-like domain
Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
22 NCK1oncoprotein31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
23 OSBPL2interactor2027.298Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
24 QTRT1interactor21.0000TGT (PF01702, IPR002616): Queuine tRNA-ribosyltransferase
25 RAP1GDS1oncoprotein21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
WAPL (PF07814, IPR022771): Wings apart-like protein regulation of heterochromatin
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
HEAT_2 (PF13646): HEAT repeats
Nitr_red_bet_C (PF14711, IPR029263): Respiratory nitrate reductase beta C-terminal
SIL1 (PF16782, IPR031884): Nucleotide exchange factor SIL1
26 RNF2interactor50.33368.169zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
27 SORT1interactor30.33328.698Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3
28 SYDE2interactor100RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
29 SYNCRIPinteractor40.50032.131RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
30 TBC1D2Binteractor100IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP
KRAB (PF01352, IPR001909, SM00349): KRAB box
PH (PF00169, IPR001849, SM00233): PH domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
31 TBC1D4interactor100DUF632 (PF04782, IPR006867): Protein of unknown function (DUF632)
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
RecR (PF02132, IPR023628): RecR protein
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF3350 (PF11830, IPR021785): Domain of unknown function (DUF3350)
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
DUF4806 (PF16064, IPR032071): Domain of unknown function (DUF4806)
32 TUBA1Aoncoprotein60.5339.524Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
33 WDR41interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
34 WISP3suppressor100Cys_knot (PF00007, IPR006208): Cystine-knot domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein

B a c k    t o    T o p ⇑