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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RBM47, SSBP2 (from a repository: Tue Jul 23 02:41:32 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins10 (34.48 %)
The number (and %) of the tumor suppressors5 (17.24 %)
Total number of binary PPIs (saturation %)96 (23.65 %)
The number (and %) of affected PPIs27 (28.12 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI5.862
Assortativity coefficient-0.3087
The network average Clustering coefficient0.519
The number (and %) of a zero Clustering coefficients5 (17.24 %)
The number (and %) of a zero Betweenness Centrality8 (27.59 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RBM47,SSBP2 All fusions
Proteins found in more fusions CDK6 (see 1 fusions); EWSR1 (see 1 fusions); TRIM33 (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RBM47parental protein50.20067.452Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
2 SSBP2parental protein220.216345.458SSDP (PF04503): Single-stranded DNA binding protein, SSDP
3 ATMsuppressor40.33313.164FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
4 BAG3oncoprotein31.0000BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
5 C1orf94interactor3019.510DUF4688 (PF15752, IPR031496): Domain of unknown function (DUF4688)
6 CDK6suppressor40.33317.432Pkinase (PF00069, IPR000719): Protein kinase domain
7 CLEC18Ainteractor100CXCXC (PF03128, IPR004153): CXCXC repeat
EGF_2 (PF07974, IPR013111): EGF-like domain
CAP (PF00188, IPR014044, SM00198): Cysteine-rich secretory protein family
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
8 DYRK2interactor2034.497Pkinase (PF00069, IPR000719): Protein kinase domain
9 ELAVL1oncoprotein70.26777.815RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 EWSR1oncoprotein70.40070.737RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
11 HSFY1interactor100HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
12 IDI2interactor70.8101.800NUDIX (PF00293, IPR000086): NUDIX domain
13 IL36RNinteractor31.0000IL1 (PF00340, IPR000975, SM00125): Interleukin-1 / 18
14 ISL1interactor90.53618.318LIM (PF00412, IPR001781, SM00132): LIM domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
15 ISL2interactor60.8001.333LIM (PF00412, IPR001781, SM00132): LIM domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
16 LDB1oncoprotein110.50927.770LIM_bind (PF01803): LIM-domain binding protein
17 LDB2interactor60.8001.333LIM_bind (PF01803): LIM-domain binding protein
18 LHX4suppressor60.7331.600LIM (PF00412, IPR001781, SM00132): LIM domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
19 LHX6suppressor51.0000BON (PF04972, IPR007055, SM00749): BON domain
LIM (PF00412, IPR001781, SM00132): LIM domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
20 LMO2oncoprotein60.40054.791CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
LIM (PF00412, IPR001781, SM00132): LIM domain
21 LMO4interactor60.8670.900LIM (PF00412, IPR001781, SM00132): LIM domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
22 LMX1Binteractor51.0000LIM (PF00412, IPR001781, SM00132): LIM domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
23 PIN1suppressor31.0000Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
24 RNF2interactor40.66713.297zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
25 SSBP3oncoprotein150.38165.090SSDP (PF04503): Single-stranded DNA binding protein, SSDP
26 SSBP4oncoprotein140.44036.092SSDP (PF04503): Single-stranded DNA binding protein, SSDP
27 TAL1oncoprotein60.8002.452HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
28 TOM1oncoprotein100GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
29 TRIM33oncoprotein90.57157.158PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Siva (PF05458, IPR022773): Cd27 binding protein (Siva)
Spectrin (PF00435, IPR002017): Spectrin repeat
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger

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