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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SLC24A3, RIN2 (from a repository: Sun Jul 7 11:48:15 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)8
The number (and %) of the onco-proteins5 (62.50 %)
The number (and %) of the tumor suppressors1 (12.50 %)
Total number of binary PPIs (saturation %)13 (46.43 %)
The number (and %) of affected PPIs7 (53.85 %)
The number of possible different fusions1
PPI diameter2
PPI radiusinf
The average degree of PPI2.250
Assortativity coefficient-0.5000
The network average Clustering coefficient0.608
The number (and %) of a zero Clustering coefficients2 (25.00 %)
The number (and %) of a zero Betweenness Centrality6 (75.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SLC24A3,RIN2 All fusions
Proteins found in more fusions EGFR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SLC24A3interactor000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Na_Ca_ex (PF01699, IPR004837): Sodium/calcium exchanger protein
NOA36 (PF06524, IPR010531): NOA36 protein
SPC25 (PF06703, IPR009582): Microsomal signal peptidase 25 kDa subunit (SPC25)
DUF3040 (PF11239, IPR021401): Protein of unknown function (DUF3040)
2 RIN2parental protein70.20023.000RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
3 CDKN2Asuppressor100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
4 EGFRoncoprotein31.0000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
5 ELAVL1oncoprotein40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
6 ERBB2oncoprotein31.0000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
7 RAB5Aoncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
8 RAB5Boncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family

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