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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DNAJC10, ICE1 (from a repository: Thu Sep 27 14:35:39 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)53
The number (and %) of the onco-proteins17 (32.08 %)
The number (and %) of the tumor suppressors9 (16.98 %)
Total number of binary PPIs (saturation %)247 (17.92 %)
The number (and %) of affected PPIs51 (20.65 %)
The number of possible different fusions13
PPI diameter5
PPI radius3
The average degree of PPI8.415
Assortativity coefficient-0.0581
The network average Clustering coefficient0.541
The number (and %) of a zero Clustering coefficients8 (15.09 %)
The number (and %) of a zero Betweenness Centrality16 (30.19 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ICE1,DNAJC10 All fusions
Proteins found in more fusions COPS5 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); CUL4A (see 4 fusions); SFTPC (see 1 fusions); SMURF2 (see 1 fusions); VCP (see 4 fusions); AIMP2 (see 1 fusions); OFD1 (see 5 fusions); TCF3 (see 4 fusions); GAN (see 1 fusions); MCM2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ICE1parental protein190.140562.413DivIC (PF04977, IPR007060): Septum formation initiator
Fez1 (PF06818): Fez1
Laminin_II (PF06009, IPR010307): Laminin Domain II
SlyX (PF04102, IPR007236): SlyX
2 DNAJC10parental protein320.250833.485DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
3 AIMP2suppressor50.33342.702GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
AIMP2_LysRS_bd (PF16780, IPR031889): AIMP2 lysyl-tRNA synthetase binding domain
4 BTRConcoprotein100.222168.046WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
5 CAND1interactor180.65464.464Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
6 CBX8interactor200Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RBR (PF17208): RNA binding Region
CBX7_C (PF17218): CBX family C-terminal motif
7 CDC42oncoprotein50.6673.200Ras (PF00071, IPR001806, SM00173): Ras family
8 CLK1interactor40.33334.756PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
9 COILinteractor60.20083.119CDC45 (PF02724, IPR003874): CDC45-like protein
Macoilin (PF09726, IPR019130): Transmembrane protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
10 COPS5protein found in more fusions170.8504.562JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
11 CUL1suppressor170.70054.840Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
12 CUL2suppressor130.9101.915Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
13 CUL3protein found in more fusions200.614127.595Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
14 CUL4Aprotein found in more fusions160.67634.930Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
15 CUL4Boncoprotein140.8684.968Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
16 CUL5suppressor160.8504.562Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
17 DCUN1D1interactor130.9360.945Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
18 DYRK1Boncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
19 EAF1suppressor60.7332.987Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Peroxin-3 (PF04882, IPR006966): Peroxin-3
EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
20 EDEM1interactor100Glyco_hydro_47 (PF01532, IPR001382): Glycosyl hydrolase family 47
21 ELLoncoprotein110.327224.368Occludin_ELL (PF07303, IPR010844): Occludin homology domain
ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
22 ELL2interactor40.6673.396Occludin_ELL (PF07303, IPR010844): Occludin homology domain
Wbp11 (PF09429, IPR019007): WW domain binding protein 11
ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
23 ELL3interactor41.0000Occludin_ELL (PF07303, IPR010844): Occludin homology domain
ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
TEX19 (PF15553, IPR029093): Testis-expressed protein 19
24 ESRRBsuppressor21.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
25 FGFR1OP2oncoprotein31.0000Cauli_AT (PF03233, IPR004917): Aphid transmission protein
DUF837 (PF05769, IPR008555): Protein of unknown function (DUF837)
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
26 FOXRED2interactor100Pyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
27 FUSsuppressor160.8426.813Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
28 GANprotein found in more fusions41.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
29 HNRNPA1interactor210.505154.233RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
30 HSPA4interactor120.65269.231Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
31 HSPA4Linteractor31.0000HSP70 (PF00012, IPR013126): Hsp70 protein
32 HSPA5oncoprotein230.506157.318HSP70 (PF00012, IPR013126): Hsp70 protein
33 ICE2interactor90.44433.900NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
34 IFI16suppressor40.33325.549HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
35 KIAA0368interactor40.33346.839HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
Ecm29 (PF13001, IPR024372): Proteasome stabiliser
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
36 MAGEA11interactor200MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
37 MCM2oncoprotein130.530255.393AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
38 MED26interactor50.8001.487Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal
Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
39 NCBP2interactor40.33341.565RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
40 NEDD8interactor150.76918.493ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
41 NTRK1oncoprotein200.497185.630I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
42 OFD1protein found in more fusions80.286129.298APG6 (PF04111, IPR007243): Autophagy protein Apg6
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
GrpE (PF01025, IPR000740): GrpE
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372)
LisH_2 (PF16045, IPR006594): LisH
43 PCSK9interactor100Peptidase_S8 (PF00082, IPR000209): Subtilase family
Inhibitor_I9 (PF05922, IPR010259): Peptidase inhibitor I9
44 PRMT7interactor100Cons_hypoth95 (PF03602, IPR004398): Conserved hypothetical protein 95
PrmA (PF06325, IPR010456): Ribosomal protein L11 methyltransferase (PrmA)
45 SFTPCprotein found in more fusions41.0000BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SP_C-Propep (PF08999, IPR015091): Surfactant protein C, N terminal propeptide
46 SMURF2protein found in more fusions305.024C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
47 SNRPA1interactor60.33374.069LRR_9 (PF14580): Leucine-rich repeat
48 TCF3suppressor200CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
49 TCTN1interactor21.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
50 TCTN3interactor21.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
51 TXNL1interactor40.33315.810PITH (PF06201, IPR010400): PITH domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
52 USPL1interactor30.6671.000zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
Peptidase_C98 (PF15499, IPR028890): Ubiquitin-specific peptidase-like, SUMO isopeptidase
DUF4650 (PF15509, IPR029388): Domain of unknown function (DUF4650)
53 VCPprotein found in more fusions170.567119.095AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)

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