Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins DNAJC10, DPYD (from a repository: Mon Aug 19 08:46:46 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 43 The number (and %) of the onco-proteins 14 (32.56 %) The number (and %) of the tumor suppressors 8 (18.60 %) Total number of binary PPIs (saturation %) 202 (22.37 %) The number (and %) of affected PPIs 41 (20.30 %) The number of possible different fusions 12 PPI diameter 5 PPI radius 3 The average degree of PPI 8.419 Assortativity coefficient -0.2127 The network average Clustering coefficient 0.505 The number (and %) of a zero Clustering coefficients 14 (32.56 %) The number (and %) of a zero Betweenness Centrality 18 (41.86 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: DNAJC10,DPYD	All fusions
Proteins found in more fusions	COPS5 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); CUL4A (see 4 fusions); SFTPC (see 1 fusions); SMURF2 (see 1 fusions); VCP (see 4 fusions); TCF3 (see 4 fusions); GAN (see 1 fusions); MCM2 (see 1 fusions); GAPDH (see 5 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	DNAJC10	parental protein	32	0.250	697.254	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain
2	DPYD	parental protein	9	0	465.905	DHO_dh (PF01180, IPR012135): Dihydroorotate dehydrogenase Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain Fer4_20 (PF14691, IPR028261): Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_21 (PF14697): 4Fe-4S dicluster domain
3	C9orf64	interactor	3	0	57.681	Q_salvage (PF10343, IPR019438): Potential Queuosine, Q, salvage protein family
4	CAND1	interactor	17	0.792	22.572	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
5	CDC42	oncoprotein	5	0.667	3.797	Ras (PF00071, IPR001806, SM00173): Ras family
6	CHAC2	interactor	1	0	0	ChaC (PF04752, IPR006840): ChaC-like protein
7	CLK1	interactor	4	0.333	56.886	PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region Pkinase (PF00069, IPR000719): Protein kinase domain
8	COPS5	protein found in more fusions	18	0.816	23.744	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
9	CUL1	suppressor	16	0.819	22.601	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
10	CUL2	suppressor	14	0.868	17.462	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
11	CUL3	protein found in more fusions	20	0.667	91.022	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
12	CUL4A	protein found in more fusions	15	0.736	20.818	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
13	CUL4B	oncoprotein	15	0.838	18.991	Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor
14	CUL5	suppressor	16	0.850	3.366	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
15	DCUN1D1	interactor	13	0.936	0.786	Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain
16	EDEM1	interactor	1	0	0	Glyco_hydro_47 (PF01532, IPR001382): Glycosyl hydrolase family 47
17	ESRRB	suppressor	3	0.333	11.766	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
18	FOXRED2	interactor	1	0	0	Pyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
19	FUS	suppressor	17	0.816	22.149	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
20	GAN	protein found in more fusions	4	1.000	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif
21	GAPDH	oncoprotein	14	0.590	358.370	Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein
22	GOPC	oncoprotein	2	0	0	DUF903 (PF06004, IPR010305): Bacterial protein of unknown function (DUF903) HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper DUF3209 (PF11483, IPR021577): Protein of unknown function (DUF3209)
23	HNRNPA1	interactor	20	0.608	106.437	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
24	HSPA4	interactor	10	0.911	0.632	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
25	HSPA4L	interactor	3	1.000	0	HSP70 (PF00012, IPR013126): Hsp70 protein
26	HSPA5	oncoprotein	23	0.506	111.306	HSP70 (PF00012, IPR013126): Hsp70 protein
27	IFI16	suppressor	3	0.667	0.667	HIN (PF02760, IPR004021): HIN-200/IF120x domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
28	LXN	suppressor	1	0	0	Latexin (PF06907, IPR009684): Latexin
29	MAGEA11	interactor	2	0	0	MAGE (PF01454, IPR002190): MAGE family MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
30	MCM2	oncoprotein	12	0.709	27.879	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
31	NAXE	interactor	1	0	0	YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
32	NEDD8	interactor	16	0.714	64.402	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
33	NTRK1	oncoprotein	19	0.582	124.043	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
34	PCSK9	interactor	1	0	0	Peptidase_S8 (PF00082, IPR000209): Subtilase family Inhibitor_I9 (PF05922, IPR010259): Peptidase inhibitor I9
35	RPE	interactor	2	0	0	OMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family Ribul_P_3_epim (PF00834, IPR000056): Ribulose-phosphate 3 epimerase family
36	SFTPC	protein found in more fusions	4	1.000	0	BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain SP_C-Propep (PF08999, IPR015091): Surfactant protein C, N terminal propeptide
37	SMURF2	protein found in more fusions	2	0	0	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
38	TCF3	suppressor	2	0	0	CDC45 (PF02724, IPR003874): CDC45-like protein HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
39	TCTN1	interactor	2	1.000	0	DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
40	TCTN3	interactor	2	1.000	0	DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
41	TRNT1	interactor	1	0	0	PolyA_pol (PF01743, IPR002646): Poly A polymerase head domain PolyA_pol_RNAbd (PF12627, IPR032828): Probable RNA and SrmB- binding site of polymerase A
42	TXNL1	interactor	2	1.000	0	PITH (PF06201, IPR010400): PITH domain Thioredoxin (PF00085, IPR013766): Thioredoxin
43	VCP	protein found in more fusions	15	0.725	15.464	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)

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