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Fusion ID: Protein names:	54431 131405
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Visualization interactions

Cytoscape Web for: parental proteins DNAJC10, TRIM71 (from a repository: Thu Dec 5 16:32:53 2019)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	41
The number (and %) of the onco-proteins	12 (29.27 %)
The number (and %) of the tumor suppressors	8 (19.51 %)
Total number of binary PPIs (saturation %)	197 (24.02 %)
The number (and %) of affected PPIs	39 (19.80 %)
The number of possible different fusions	11
PPI diameter	5
PPI radius	3
The average degree of PPI	8.732
Assortativity coefficient	-0.1785
The network average Clustering coefficient	0.554
The number (and %) of a zero Clustering coefficients	9 (21.95 %)
The number (and %) of a zero Betweenness Centrality	16 (39.02 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: DNAJC10,TRIM71	All fusions
Proteins found in more fusions	COPS5 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); CUL4A (see 4 fusions); SFTPC (see 1 fusions); SMURF2 (see 1 fusions); VCP (see 4 fusions); TCF3 (see 4 fusions); GAN (see 1 fusions); MCM2 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	DNAJC10	parental protein	32	0.250	668.523	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain
2	TRIM71	parental protein	7	0.095	234.495	DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) Filamin (PF00630, IPR017868): Filamin/ABP280 repeat NHL (PF01436, IPR001258): NHL repeat FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF4094 (PF13334, IPR025298): Domain of unknown function (DUF4094) zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain DUF5128 (PF17170): 6-bladed beta-propeller
3	AGO2	interactor	10	0.511	164.196	ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
4	CAND1	interactor	17	0.767	21.044	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
5	CDC42	oncoprotein	5	0.667	1.667	Ras (PF00071, IPR001806, SM00173): Ras family
6	COPS5	protein found in more fusions	19	0.706	94.629	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
7	CUL1	suppressor	16	0.800	19.353	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
8	CUL2	suppressor	14	0.835	17.701	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
9	CUL3	protein found in more fusions	20	0.661	74.145	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
10	CUL4A	protein found in more fusions	17	0.575	86.047	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
11	CUL4B	oncoprotein	14	0.868	2.746	Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor
12	CUL5	suppressor	17	0.794	21.605	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
13	DCUN1D1	interactor	13	0.936	0.905	Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain
14	DICER1	suppressor	6	0.500	57.934	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Dicer_dimer (PF03368, IPR005034): Dicer dimerisation domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
15	EDEM1	interactor	1	0	0	Glyco_hydro_47 (PF01532, IPR001382): Glycosyl hydrolase family 47
16	ESRRB	suppressor	2	1.000	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
17	FOXRED2	interactor	1	0	0	Pyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
18	FUS	suppressor	16	0.842	4.034	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
19	GAN	protein found in more fusions	4	1.000	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif
20	HIST1H1A	interactor	4	0.333	40.397	Mucin (PF01456, IPR000458): Mucin-like glycoprotein Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
21	HNRNPA1	interactor	18	0.684	26.714	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
22	HSPA4	interactor	10	0.911	0.671	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
23	HSPA4L	interactor	3	1.000	0	HSP70 (PF00012, IPR013126): Hsp70 protein
24	HSPA5	oncoprotein	23	0.506	116.534	HSP70 (PF00012, IPR013126): Hsp70 protein
25	IFI16	suppressor	4	0.333	14.736	HIN (PF02760, IPR004021): HIN-200/IF120x domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
26	LIN28A	interactor	1	0	0	CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain zf-CCHC (PF00098, IPR001878): Zinc knuckle zf-CCHC_6 (PF15288): Zinc knuckle
27	LIN28B	interactor	3	0.333	17.491	CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain zf-CCHC (PF00098, IPR001878): Zinc knuckle
28	MAGEA11	interactor	2	0	0	MAGE (PF01454, IPR002190): MAGE family MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
29	MCM2	oncoprotein	12	0.636	47.080	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
30	NEDD8	interactor	14	0.872	2.229	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
31	NTRK1	oncoprotein	19	0.575	95.230	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
32	PCSK9	interactor	1	0	0	Peptidase_S8 (PF00082, IPR000209): Subtilase family Inhibitor_I9 (PF05922, IPR010259): Peptidase inhibitor I9
33	SFTPC	protein found in more fusions	4	1.000	0	BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain SP_C-Propep (PF08999, IPR015091): Surfactant protein C, N terminal propeptide
34	SMURF2	protein found in more fusions	2	0	0	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
35	TCF3	suppressor	2	0	0	CDC45 (PF02724, IPR003874): CDC45-like protein HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
36	TCTN1	interactor	2	1.000	0	DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
37	TCTN3	interactor	2	1.000	0	DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
38	THAP2	interactor	1	0	0	THAP (PF05485, IPR006612, SM00980): THAP domain
39	TRAK2	interactor	1	0	0	ZapB (PF06005, IPR009252): Cell division protein ZapB HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region Milton (PF12448, IPR022154): Kinesin associated protein
40	TXNL1	interactor	2	1.000	0	PITH (PF06201, IPR010400): PITH domain Thioredoxin (PF00085, IPR013766): Thioredoxin
41	VCP	protein found in more fusions	15	0.725	15.891	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)

B a c k t o T o p ⇑

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Visualization interactions

Statistics and Network structure information

List of the fusions

List of active interactors