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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins POLRMT, LOC107985046 (from a repository: Sun Nov 10 07:42:44 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins5 (19.23 %)
The number (and %) of the tumor suppressors2 (7.69 %)
Total number of binary PPIs (saturation %)58 (17.85 %)
The number (and %) of affected PPIs24 (41.38 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI3.615
Assortativity coefficient-0.3935
The network average Clustering coefficient0.525
The number (and %) of a zero Clustering coefficients8 (30.77 %)
The number (and %) of a zero Betweenness Centrality17 (65.38 %)


List of the fusions

PPI for parental proteins: LOC107985046,POLRMT All fusions
Proteins found in more fusions CUL3 (see 1 fusions); CISD3 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 LOC107985046interactor000NA
2 POLRMTparental protein240.083461.333DUF615 (PF04751, IPR006839): Protein of unknown function (DUF615)
PSD2 (PF07624, IPR011478): Protein of unknown function (DUF1585)
RNA_pol (PF00940, IPR002092): DNA-dependent RNA polymerase
PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
RPOL_N (PF14700, IPR029262): DNA-directed RNA polymerase N-terminal
3 CHCHD2interactor31.0000CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
4 CISD3protein found in more fusions31.0000zf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MOLO1 (PF17175): Modulator of levamisole receptor-1
5 CLEC11Ainteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HBS1_N (PF08938, IPR015033): HBS1 N-terminus
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
6 CUL3protein found in more fusions80.42911.667Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
7 FOXQ1interactor21.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
8 HDGFinteractor31.0000PWWP (PF00855, IPR000313, SM00293): PWWP domain
9 HECW2interactor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
10 KBTBD7interactor30.6670.667BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
11 KCTD17interactor40.6671.000BTB_2 (PF02214, IPR003131): BTB/POZ domain
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
12 LDHDinteractor21.0000FAD-oxidase_C (PF02913, IPR004113): FAD linked oxidases, C-terminal domain
FAD_binding_4 (PF01565, IPR006094): FAD binding domain
13 LTBRoncoprotein200Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
14 MEX3Cinteractor100KH_1 (PF00013, IPR004088, SM00322): KH domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
15 MRPL58interactor100RF-1 (PF00472, IPR000352): RF-1 domain
16 NESinteractor40.8330.667Anthrax-tox_M (PF09156, IPR015239): Anthrax toxin lethal factor, middle domain
Filament (PF00038, IPR001664): Intermediate filament protein
HSCB_C (PF07743, IPR009073): HSCB C-terminal oligomerisation domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Prominin (PF05478, IPR008795): Prominin
17 NFKBIAoncoprotein21.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
18 NTRK1oncoprotein70.6673.333I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
19 OXLD1interactor100Oxidored-like (PF09791, IPR019180): Oxidoreductase-like protein, N-terminal
20 RPL10suppressor80.46412.667Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
21 SIRT7interactor50.5004.667DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
22 SKAP1interactor200PH (PF00169, IPR001849, SM00233): PH domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
23 TARDBPinteractor51.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
24 TFB1Minteractor21.0000RrnaAD (PF00398, IPR001737, SM00650): Ribosomal RNA adenine dimethylase
25 TP53suppressor70.33310.000DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
26 TRIM10interactor200IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
SPRY (PF00622, IPR003877, SM00449): SPRY domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING

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