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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PODXL, VPS13B (from a repository: Mon Jul 22 19:29:06 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins1 (6.25 %)
The number (and %) of the tumor suppressors1 (6.25 %)
Total number of binary PPIs (saturation %)20 (16.67 %)
The number (and %) of affected PPIs14 (70.00 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI2.000
Assortativity coefficient-0.1656
The network average Clustering coefficient0.169
The number (and %) of a zero Clustering coefficients12 (75.00 %)
The number (and %) of a zero Betweenness Centrality13 (81.25 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: VPS13B,PODXL All fusions
Proteins found in more fusions LGALS3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 VPS13Bparental protein4012.000ATG_C (PF09333, IPR015412): Autophagy-related protein C terminal domain
SHR-BD (PF06650, IPR009543): SHR-binding domain of vacuolar-sorting associated protein 13
Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
VPS13_C (PF16909, IPR031645): Vacuolar-sorting-associated 13 protein C-terminal
2 PODXLparental protein100.04485.000CD34_antigen (PF06365, IPR013836): CD34/Podocalyxin family
DUF3439 (PF11921, IPR024592): Domain of unknown function (DUF3439)
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
CC190 (PF15768, IPR031525): Coiled-coil domain-containing protein 190
3 CDK2suppressor200Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
4 CSNK1Einteractor200APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
5 DNAJC7interactor100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_17 (PF13431): Tetratricopeptide repeat
6 FAM177A1interactor100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Connexin (PF00029, IPR013092, SM00037): Connexin
FAM177 (PF14774, IPR028260): FAM177 family
7 FCN1interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
8 LGALS3oncoprotein31.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
9 LGALS8interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
10 LGALS9interactor30.6671.000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
11 NXF1interactor200NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
12 PILRAinteractor100SKG6 (PF08693, IPR014805): Transmembrane alpha-helix domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
G6B (PF15096, IPR028070): G6B family
13 SELLinteractor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
MWFE (PF15879, IPR017384): NADH-ubiquinone oxidoreductase MWFE subunit
14 SLC9A3R2interactor21.0000EBP50_C (PF09007, IPR015098): EBP50, C-terminal
GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
15 SPACA1interactor100DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
16 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)

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