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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SYNGR1, PMP22 (from a repository: Fri Jul 26 10:26:45 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins3 (20.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)23 (21.90 %)
The number (and %) of affected PPIs13 (56.52 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI2.533
Assortativity coefficient-0.1784
The network average Clustering coefficient0.342
The number (and %) of a zero Clustering coefficients8 (53.33 %)
The number (and %) of a zero Betweenness Centrality10 (66.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SYNGR1,PMP22 All fusions
Proteins found in more fusions SYVN1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SYNGR1parental protein306.000MARVEL (PF01284, IPR008253): Membrane-associating domain
2 PMP22parental protein100.13373.000PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
3 AMFRoncoprotein50.6672.000CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
4 CANXinteractor31.0000Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
5 CREB3interactor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
6 DDX52interactor100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
CK1gamma_C (PF12605, IPR022247): Casein kinase 1 gamma C terminal
7 ELAVL1oncoprotein50.6672.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 FATE1interactor100Miff (PF05644, IPR008518): Mitochondrial and peroxisomal fission factor Mff
9 HMOX2interactor100Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
10 KLRC1interactor100UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
11 MPZinteractor100DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Myelin-PO_C (PF10570, IPR019566): Myelin-PO cytoplasmic C-term p65 binding region
12 PEX19interactor21.0000Pex19 (PF04614, IPR006708): Pex19 protein family
Rod-binding (PF10135, IPR019301): Rod binding protein
13 RER1interactor21.0000Rer1 (PF03248, IPR004932): Rer1 family
14 SMIM3interactor100Renin_r (PF07850, IPR012493): Renin receptor-like protein
Epiglycanin_C (PF14654, IPR028199): Mucin, catalytic, TM and cytoplasmic tail region
15 SYVN1protein found in more fusions40.6671.000Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain

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