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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)72
The number (and %) of the onco-proteins17 (23.61 %)
The number (and %) of the tumor suppressors8 (11.11 %)
Total number of binary PPIs (saturation %)312 (12.21 %)
The number (and %) of affected PPIs71 (22.76 %)
The number of possible different fusions14
PPI diameter4
PPI radius2
The average degree of PPI7.917
Assortativity coefficient-0.1811
The network average Clustering coefficient0.488
The number (and %) of a zero Clustering coefficients6 (8.33 %)
The number (and %) of a zero Betweenness Centrality13 (18.06 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TDRD3,PLS3 All fusions
Proteins found in more fusions EWSR1 (see 2 fusions); APP (see 4 fusions); HLA-B (see 2 fusions); STAU1 (see 2 fusions); EZR (see 2 fusions); TKT (see 5 fusions); EGFR (see 2 fusions); POLR2A (see 2 fusions); SHC1 (see 1 fusions); THOC1 (see 3 fusions); PABPC1 (see 2 fusions); SOD1/TAGLN2 (see 1 fusions); SERBP1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TDRD3parental protein300.1011113.069RMI1_N (PF08585, IPR013894, SM01161): RecQ mediated genome instability protein
TUDOR (PF00567, IPR002999, SM00333): Tudor domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
DUF3472 (PF11958, IPR021862): Domain of unknown function (DUF3472)
2 PLS3parental protein410.1351409.098CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
3 ANXA6interactor50.8001.980Annexin (PF00191, IPR018502, SM00335): Annexin
4 APPprotein found in more fusions110.22264.262APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ARHGDIAinteractor80.7145.228Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
6 CC2D2Ainteractor202.316C2 (PF00168, IPR000008, SM00239): C2 domain
ZnuA (PF01297, IPR006127): Zinc-uptake complex component A periplasmic
DUF4240 (PF14024, IPR025334): Protein of unknown function (DUF4240)
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
CC2D2AN-C2 (PF15625, IPR028928): CC2D2A N-terminal C2 domain
7 CLNS1Ainteractor30.33314.624Voldacs (PF03517): Regulator of volume decrease after cellular swelling
8 CUL5suppressor110.40038.730Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
9 DCTN1interactor305.385Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
10 DDX3Xsuppressor70.28632.693DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
11 DHX15interactor120.242126.801DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
AAA_29 (PF13555): P-loop containing region of AAA domain
12 EEF1A1suppressor160.238182.009GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
13 EGFRoncoprotein120.40027.790Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
14 ENO2interactor130.500112.596Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
15 EWSR1oncoprotein200.234421.262RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
16 EZRprotein found in more fusions140.56432.875DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
17 FAM96Ainteractor21.0000DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
18 FAM96Binteractor21.0000DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
19 FDPSinteractor60.6007.670polyprenyl_synt (PF00348, IPR000092): Polyprenyl synthetase
20 FIGNL1interactor205.385AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
21 FKBP14interactor100FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
22 FMR1interactor80.42933.200Agenet (PF05641, IPR008395, SM00743): Agenet domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXMR_C2 (PF16098, IPR032196): Fragile X-related mental retardation protein C-terminal region 2
23 FUSsuppressor120.273109.519Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
24 FXR1interactor70.60052.665Agenet (PF05641, IPR008395, SM00743): Agenet domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
FXR_C3 (PF16097, IPR032177): Fragile X-related 1 protein C-terminal region 3
25 FXR2interactor60.7007.794Agenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
26 HARSinteractor30.6679.352HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
27 HDGFinteractor60.6005.412PWWP (PF00855, IPR000313, SM00293): PWWP domain
28 HIST3H3interactor30.6673.244Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
29 HLA-Boncoprotein41.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
30 HSPE1interactor150.43856.081Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
31 IKBKEinteractor50.16712.452IncA (PF04156, IPR007285): IncA protein
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
32 ISG15suppressor80.28628.366ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
33 KCTD2oncoprotein100BTB_2 (PF02214, IPR003131): BTB/POZ domain
34 LCA5interactor100IncA (PF04156, IPR007285): IncA protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Tantalus (PF15386, IPR028149): Drosophila Tantalus-like
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
35 LUZP4interactor80.190158.293Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
36 MAGOHinteractor120.22793.243Mago_nashi (PF02792, IPR004023): Mago nashi protein
37 MSNoncoprotein130.50048.043DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
38 MYO5Ainteractor21.0000DIL (PF01843, IPR018444, SM01132): DIL domain
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
SOGA (PF11365, IPR027881): Protein SOGA
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
CYTL1 (PF15153, IPR029253): Cytokine-like protein 1
39 NINLinteractor21.0000PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
TBCA (PF02970, IPR004226): Tubulin binding cofactor A
DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
40 NTRK1oncoprotein390.1371130.919I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
41 PABPC1oncoprotein130.33388.463RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
YflT (PF11181, IPR025889): Heat induced stress protein YflT
42 POC1Ainteractor30.33326.610WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
43 POLR2Aprotein found in more fusions90.39340.738RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
44 PSMD6interactor21.0000RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
45 RANBP1interactor41.0000PKI (PF02827, IPR004171): cAMP-dependent protein kinase inhibitor
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
46 RBM8Ainteractor80.33338.380RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
47 RDXinteractor90.66710.589ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
48 RNPS1interactor40.8333.244RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
Macoilin (PF09726, IPR019130): Transmembrane protein
49 RPL28interactor31.0000Ribosomal_L28e (PF01778, IPR029004): Ribosomal L28e protein family
50 RPS6interactor100.44470.987Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
51 SERBP1protein found in more fusions80.33340.004HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
52 SHC1oncoprotein50.8330.898PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
53 SND1interactor70.33334.442TUDOR (PF00567, IPR002999, SM00333): Tudor domain
SNase (PF00565, IPR016071, SM00318): Staphylococcal nuclease homologue
54 SNX3interactor30.6670.400PX (PF00787, IPR001683, SM00312): PX domain
55 SOD1protein found in more fusions90.6798.913Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
56 SORDinteractor70.6674.832ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
57 STAU1protein found in more fusions120.291113.273dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
58 STIP1interactor150.50553.437TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): WTAP/Mum2p family
59 TAGLNsuppressor60.5336.222Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
60 TAGLN2protein found in more fusions110.61819.136Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
61 TALDO1interactor80.6079.246TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
62 THG1Linteractor31.0000Thg1 (PF04446, IPR024956): tRNAHis guanylyltransferase
Thg1C (PF14413, IPR025845): Thg1 C terminal domain
63 THOC1protein found in more fusions60.50012.459Death (PF00531, IPR000488, SM00005): Death domain
efThoc1 (PF11957, IPR021861): THO complex subunit 1 transcription elongation factor
64 THOP1interactor80.5008.828Peptidase_M3 (PF01432, IPR001567): Peptidase family M3
65 TKTprotein found in more fusions140.55134.747Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
66 TOP3Binteractor60.40014.365Topoisom_bac (PF01131, IPR013497): DNA topoisomerase
Toprim (PF01751, IPR006171, SM00493): Toprim domain
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zinc_ribbon_4 (PF13717): zinc-ribbon domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
67 TP63suppressor50.33321.711Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
68 TXNRD1interactor40.6672.751Glutaredoxin (PF00462, IPR002109): Glutaredoxin
Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
69 TYMSinteractor21.0000Thymidylat_synt (PF00303, IPR000398): Thymidylate synthase
70 UFD1Linteractor50.4008.110UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
71 UNKinteractor60.26728.976MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
72 WWOXsuppressor60.46713.884adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain

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