Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins SRSF1, BCL11A (from a repository: Sat Jul 27 11:33:05 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 184 The number (and %) of the onco-proteins 54 (29.35 %) The number (and %) of the tumor suppressors 26 (14.13 %) Total number of binary PPIs (saturation %) 2852 (16.94 %) The number (and %) of affected PPIs 187 (6.56 %) The number of possible different fusions 42 PPI diameter 4 PPI radius 2 The average degree of PPI 30.130 Assortativity coefficient -0.0573 The network average Clustering coefficient 0.438 The number (and %) of a zero Clustering coefficients 7 (3.80 %) The number (and %) of a zero Betweenness Centrality 9 (4.89 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: BCL11A,SRSF1	All fusions
Proteins found in more fusions	GRK5 (see 2 fusions); PRPF19 (see 2 fusions); U2AF2 (see 2 fusions); NPM1 (see 1 fusions); BCL6 (see 2 fusions); CUL1 (see 3 fusions); PARK2 (see 1 fusions); EWSR1 (see 1 fusions); PIAS1 (see 3 fusions); XBP1 (see 2 fusions); HDAC5 (see 1 fusions); DDX5 (see 1 fusions); IK (see 1 fusions); SUZ12 (see 2 fusions); SNW1 (see 1 fusions); ZMYND11 (see 1 fusions); APP (see 5 fusions); SRSF2 (see 1 fusions); HUWE1 (see 4 fusions); SRPK2 (see 1 fusions); COPS5/HNRNPH3 (see 3 fusions); SNRNP200 (see 2 fusions); LUC7L3 (see 1 fusions); DDX17 (see 4 fusions); EZH2 (see 1 fusions); CHD4 (see 6 fusions); STAU1 (see 2 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); CDK6 (see 1 fusions); AHCYL1 (see 2 fusions); NR2F2 (see 1 fusions); COPS5 (see 1 fusions); UBC (see 7 fusions); TP53 (see 3 fusions); SREK1 (see 6 fusions); LUC7L2 (see 1 fusions); SFN (see 1 fusions); LNX1 (see 1 fusions); UBR5 (see 4 fusions); SRSF1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	BCL11A	parental protein	31	0.131	1578.719	BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II) C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-HIT (PF04438, IPR007529): HIT zinc finger zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
2	SRSF1	parental protein	156	0.198	7145.845	Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
3	ACTC1	interactor	6	0.200	40.909	Actin (PF00022, IPR004000, SM00268): Actin
4	AHCYL1	suppressor	10	0.389	6.790	AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515) Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
5	AIRE	interactor	11	0.489	5.502	PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain
6	ALYREF	interactor	42	0.474	79.156	FYTT (PF07078, IPR009782): Forty-two-three protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
7	APP	protein found in more fusions	45	0.237	737.392	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
8	BARD1	suppressor	36	0.338	128.754	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
9	BCL10	suppressor	5	0.833	0.447	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
10	BCL6	oncoprotein	9	0.357	43.932	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding DZR (PF12773, IPR025874): Double zinc ribbon zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
11	BRCA1	suppressor	24	0.399	64.221	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
12	C1QBP	interactor	27	0.342	66.880	MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
13	CACNA1A	interactor	2	0	5.873	Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain GRP (PF07172, IPR010800): Glycine rich protein family Ion_trans (PF00520, IPR005821): Ion transport protein Roughex (PF06020, IPR009259): Drosophila roughex protein SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
14	CAND1	interactor	72	0.413	288.965	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
15	CDC5L	interactor	67	0.415	336.574	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
16	CDCA3	interactor	4	0.167	17.712	NA
17	CDK4	oncoprotein	10	0.422	39.180	Pkinase (PF00069, IPR000719): Protein kinase domain
18	CDK6	suppressor	13	0.379	107.364	Pkinase (PF00069, IPR000719): Protein kinase domain
19	CHD4	oncoprotein	24	0.407	144.257	CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27 CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain DTHCT (PF08070, IPR012542): DTHCT (NUC029) region DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086) DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087) PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain FAM176 (PF14851): FAM176 family Coilin_N (PF15862, IPR031722): Coilin N-terminus
20	CIR1	interactor	4	1.000	0	DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) EVI2A (PF05399, IPR008608): Ectropic viral integration site 2A protein (EVI2A) Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 IncA (PF04156, IPR007285): IncA protein Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR YebO (PF13974, IPR025594): YebO-like protein CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
21	CLK1	interactor	18	0.537	7.745	PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region Pkinase (PF00069, IPR000719): Protein kinase domain
22	COPS5	protein found in more fusions	62	0.438	210.398	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
23	CUL1	suppressor	59	0.467	301.333	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
24	CUL2	suppressor	44	0.480	69.928	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
25	CUL3	protein found in more fusions	81	0.356	755.181	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
26	CUL4B	oncoprotein	36	0.414	149.311	Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor
27	CUL7	protein found in more fusions	69	0.340	351.672	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
28	CXCL1	oncoprotein	3	1.000	0	IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
29	DDX17	protein found in more fusions	49	0.434	170.649	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Ferritin (PF00210, IPR008331): Ferritin-like domain GRP (PF07172, IPR010800): Glycine rich protein family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
30	DDX5	oncoprotein	63	0.414	315.322	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
31	DHX15	interactor	54	0.474	130.353	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain AAA_29 (PF13555): P-loop containing region of AAA domain
32	DHX9	oncoprotein	56	0.436	170.286	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
33	DIDO1	suppressor	6	0.733	0.552	PHD (PF00628, IPR019787, SM00249): PHD-finger SlyX (PF04102, IPR007236): SlyX SPOC (PF07744, IPR012921): SPOC domain TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
34	DYRK1A	oncoprotein	13	0.424	9.147	DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Pkinase (PF00069, IPR000719): Protein kinase domain FAM199X (PF15814, IPR029672): Protein family FAM199X
35	ECT2	suppressor	10	0.356	16.018	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
36	EED	suppressor	61	0.354	324.946	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
37	EFTUD2	interactor	46	0.482	100.660	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
38	EIF4A3	interactor	62	0.464	259.589	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
39	ELAVL1	oncoprotein	71	0.252	1429.881	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
40	ESR1	suppressor	70	0.267	1060.633	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
41	EWSR1	oncoprotein	47	0.400	230.051	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
42	EZH2	suppressor	36	0.382	109.217	CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
43	FBXO6	interactor	28	0.439	35.364	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
44	FN1	oncoprotein	42	0.366	126.294	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
45	GCN1	interactor	17	0.478	8.331	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat CLASP_N (PF12348, IPR024395): CLASP N terminal MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
46	GMCL1P1	interactor	4	0.500	9.996	NA
47	GNAI2	oncoprotein	6	0.667	0.696	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
48	GRK5	protein found in more fusions	17	0.392	44.646	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
49	HABP4	interactor	7	0.381	13.087	HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
50	HDAC1	suppressor	34	0.297	422.234	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
51	HDAC2	suppressor	38	0.342	390.742	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
52	HDAC5	protein found in more fusions	38	0.369	232.398	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
53	HDGF	interactor	33	0.356	109.405	PWWP (PF00855, IPR000313, SM00293): PWWP domain
54	HIPK3	interactor	8	0.429	64.996	Pkinase (PF00069, IPR000719): Protein kinase domain
55	HNRNPA0	interactor	36	0.651	29.488	SAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus
56	HNRNPA1	interactor	70	0.423	283.435	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
57	HNRNPDL	interactor	31	0.596	28.453	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
58	HNRNPF	interactor	41	0.562	55.737	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14 zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
59	HNRNPH3	protein found in more fusions	30	0.591	19.119	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
60	HNRNPK	oncoprotein	61	0.443	389.722	ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain
61	HNRNPM	interactor	63	0.390	386.781	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
62	HNRNPR	interactor	56	0.488	164.812	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
63	HNRNPU	interactor	69	0.379	313.875	CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
64	HUWE1	oncoprotein	36	0.368	99.868	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
65	IGBP1	interactor	6	0.333	9.732	TAP42 (PF04177, IPR007304): TAP42-like family
66	IK	protein found in more fusions	29	0.489	37.569	Lsm_interact (PF05391, IPR008669): Lsm interaction motif RED_C (PF07807, IPR012492): RED-like protein C-terminal region RED_N (PF07808, IPR012916): RED-like protein N-terminal region PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
67	ILVBL	interactor	4	0.667	1.072	TPP_enzyme_C (PF02775, IPR011766): Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain TPP_enzyme_N (PF02776, IPR012001): Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
68	LMO1	oncoprotein	1	0	0	LIM (PF00412, IPR001781, SM00132): LIM domain Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
69	LNX1	protein found in more fusions	7	0.333	12.357	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
70	LOC255308	interactor	3	0.667	0.400	NA
71	LUC7L2	protein found in more fusions	46	0.392	159.504	LUC7 (PF03194, IPR004882): LUC7 N_terminus Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
72	LUC7L3	protein found in more fusions	31	0.405	48.151	LUC7 (PF03194, IPR004882): LUC7 N_terminus Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
73	LUZP4	interactor	13	0.682	2.705	Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
74	MAGOH	interactor	43	0.427	127.929	Mago_nashi (PF02792, IPR004023): Mago nashi protein
75	MBD3	interactor	17	0.442	92.979	DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
76	MBD3L1	interactor	8	1.000	0	MBD_C (PF14048, IPR025884): C-terminal domain of methyl-CpG binding protein 2 and 3 MBDa (PF16564, IPR032343): p55-binding region of Methyl-CpG-binding domain proteins MBD
77	MDC1	suppressor	23	0.375	48.839	FHA (PF00498, IPR000253, SM00240): FHA domain DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274) Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
78	MOV10	interactor	35	0.341	226.043	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
79	MPG	interactor	8	0.500	3.068	Pur_DNA_glyco (PF02245, IPR003180): Methylpurine-DNA glycosylase (MPG)
80	MTA1	oncoprotein	19	0.532	87.662	BAH (PF01426, IPR001025, SM00439): BAH domain ELM2 (PF01448, IPR000949): ELM2 domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain GATA (PF00320, IPR000679, SM00401): GATA zinc finger
81	MTA2	interactor	25	0.367	199.005	BAH (PF01426, IPR001025, SM00439): BAH domain ELM2 (PF01448, IPR000949): ELM2 domain Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain GATA (PF00320, IPR000679, SM00401): GATA zinc finger
82	NCK2	interactor	7	0.200	29.343	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
83	NCSTN	interactor	25	0.343	74.366	Nicastrin (PF05450, IPR008710): Nicastrin Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
84	NPM1	suppressor	50	0.308	295.690	Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
85	NR2E1	interactor	5	0.400	9.832	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
86	NR2E3	interactor	1	0	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
87	NR2F1	oncoprotein	4	0	20.303	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
88	NR2F2	protein found in more fusions	6	0.300	14.172	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
89	NR2F6	oncoprotein	4	0.167	22.406	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
90	NTRK1	oncoprotein	87	0.312	1070.742	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
91	NXF1	interactor	45	0.407	178.220	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
92	OBSL1	interactor	73	0.324	391.216	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
93	PAN2	interactor	20	0.463	48.641	RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain
94	PARK2	suppressor	30	0.382	59.693	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
95	PAXIP1	interactor	25	0.360	58.645	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase SURF6 (PF04935, IPR007019): Surfeit locus protein 6 DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance PTCB-BRCT (PF12738, IPR001357): twin BRCT domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
96	PHF20L1	interactor	9	0.639	8.891	MBT (PF02820, IPR004092, SM00561): mbt repeat PHD (PF00628, IPR019787, SM00249): PHD-finger U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34 DUF3776 (PF12618, IPR022255): Protein of unknown function (DUF3776) CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537) PEHE (PF15275, IPR029332): PEHE domain EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus PHD20L1_u1 (PF16660): PHD finger protein 20-like protein 1
97	PHGDH	interactor	37	0.339	120.789	2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
98	PIAS1	suppressor	13	0.485	15.270	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
99	PIAS3	oncoprotein	7	0.381	27.013	SAP (PF02037, IPR003034, SM00513): SAP domain zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain
100	PRPF19	protein found in more fusions	51	0.509	96.035	Prp19 (PF08606, IPR013915): Prp19/Pso4-like WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
101	PRPF4	interactor	26	0.647	15.012	PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_like (PF17005, IPR031544): WD40-like domain
102	PRPF4B	oncoprotein	18	0.503	14.008	Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking Ureide_permease (PF07168, IPR009834): Ureide permease Pkinase (PF00069, IPR000719): Protein kinase domain Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
103	PSIP1	oncoprotein	13	0.474	8.569	AT_hook (PF02178, IPR017956, SM00384): AT hook motif BEX (PF04538, IPR021156): Brain expressed X-linked like family DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) PGA2 (PF07543, IPR011431): Protein trafficking PGA2 PWWP (PF00855, IPR000313, SM00293): PWWP domain LEDGF (PF11467, IPR021567): Lens epithelium-derived growth factor (LEDGF) TERB2 (PF15101, IPR028065): Telomere-associated protein TERB2
104	RBBP7	suppressor	21	0.429	114.588	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
105	RBM14	suppressor	37	0.455	62.592	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
106	RBM39	oncoprotein	53	0.403	171.839	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
107	RNF2	interactor	58	0.331	293.153	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
108	RNPS1	interactor	47	0.479	96.430	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) Macoilin (PF09726, IPR019130): Transmembrane protein
109	RRP1B	interactor	22	0.506	25.931	Nop52 (PF05997, IPR010301): Nucleolar protein,Nop52
110	SAP18	interactor	32	0.389	108.854	SAP18 (PF06487, IPR010516): Sin3 associated polypeptide p18 (SAP18)
111	SART1	interactor	47	0.434	152.954	SART-1 (PF03343, IPR005011): SART-1 family Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
112	SCAF11	interactor	5	0.800	0.217	DUF566 (PF04484, IPR007573): Family of unknown function (DUF566) Phage_XkdX (PF09693, IPR010022): Phage uncharacterised protein (Phage_XkdX) zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
113	SF3A1	interactor	50	0.457	169.608	TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Surp (PF01805, IPR000061, SM00648): Surp module ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
114	SF3A2	interactor	40	0.554	44.018	Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like Totivirus_coat (PF05518, IPR008871): Totivirus coat protein zf-met (PF12874): Zinc-finger of C2H2 type ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
115	SF3B1	oncoprotein	52	0.473	143.637	Dopey_N (PF04118, IPR007249): Dopey, N-terminal HEAT (PF02985, IPR000357): HEAT repeat SF3b1 (PF08920, IPR015016): Splicing factor 3B subunit 1 UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
116	SF3B3	interactor	51	0.493	108.535	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
117	SFN	suppressor	21	0.374	39.440	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
118	SHMT2	interactor	19	0.456	19.167	SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
119	SIRT1	suppressor	18	0.419	72.827	DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592) SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
120	SLC30A1	interactor	2	1.000	0	Cation_efflux (PF01545, IPR002524): Cation efflux family ZT_dimer (PF16916, IPR027470): Dimerisation domain of Zinc Transporter
121	SLC30A5	oncoprotein	2	1.000	0	Cation_efflux (PF01545, IPR002524): Cation efflux family DUF4199 (PF13858, IPR025250): Protein of unknown function (DUF4199)
122	SMARCAD1	interactor	20	0.537	138.704	CUE (PF02845, IPR003892, SM00546): CUE domain Pox_D5 (PF03288, IPR004968): Poxvirus D5 protein-like SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
123	SMU1	interactor	20	0.521	13.221	LisH (PF08513, IPR013720, SM00667): LisH WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
124	SMURF1	interactor	24	0.395	119.324	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
125	SNAP23	interactor	5	0.833	0.143	DivIC (PF04977, IPR007060): Septum formation initiator DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 SNAP-25 (PF00835, IPR000928): SNAP-25 family DUF5089 (PF17002, IPR031547): Domain of unknown function (DUF5089)
126	SNIP1	interactor	14	0.593	7.225	FHA (PF00498, IPR000253, SM00240): FHA domain MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 FAM176 (PF14851): FAM176 family
127	SNRNP200	protein found in more fusions	49	0.480	113.861	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase DUF603 (PF04645, IPR006739): Protein of unknown function, DUF603 Sec63 (PF02889, IPR004179, SM00973): Sec63 Brl domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
128	SNRNP70	interactor	46	0.468	89.759	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
129	SNRPA1	interactor	36	0.546	57.406	LRR_9 (PF14580): Leucine-rich repeat
130	SNW1	protein found in more fusions	66	0.409	403.165	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
131	SPRTN	interactor	12	0.470	6.302	GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term SprT-like (PF10263, IPR006640, SM00731): SprT-like family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
132	SREK1	protein found in more fusions	30	0.478	28.632	Ureide_permease (PF07168, IPR009834): Ureide permease RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
133	SRPK1	interactor	42	0.456	159.446	FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) Pkinase (PF00069, IPR000719): Protein kinase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
134	SRPK2	oncoprotein	46	0.422	215.816	DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
135	SRPK3	interactor	18	0.464	10.892	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein Pkinase (PF00069, IPR000719): Protein kinase domain
136	SRRM2	interactor	62	0.390	353.872	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
137	SRSF10	interactor	38	0.309	135.828	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
138	SRSF11	interactor	38	0.435	92.664	Rtf2 (PF04641, IPR027799): Rtf2 RING-finger RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TP2 (PF01254, IPR000678): Nuclear transition protein 2 Transformer (PF06495, IPR010519): Fruit fly transformer protein FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
139	SRSF2	oncoprotein	44	0.398	139.435	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TP2 (PF01254, IPR000678): Nuclear transition protein 2 Transformer (PF06495, IPR010519): Fruit fly transformer protein Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
140	SRSF3	oncoprotein	58	0.357	285.655	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
141	SRSF4	interactor	28	0.444	45.210	Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
142	SRSF5	interactor	49	0.366	218.945	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
143	SRSF6	oncoprotein	43	0.426	115.202	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Tox-HNH-EHHH (PF15657, IPR028048): HNH/Endo VII superfamily nuclease toxins
144	SRSF7	interactor	62	0.388	281.189	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TP2 (PF01254, IPR000678): Nuclear transition protein 2 zf-CCHC (PF00098, IPR001878): Zinc knuckle
145	SRSF9	interactor	37	0.450	92.103	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
146	SSR1	interactor	12	0.424	7.978	TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
147	STAU1	protein found in more fusions	44	0.468	94.682	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
148	SUB1	interactor	17	0.292	28.066	Dehydrin (PF00257, IPR000167): Dehydrin PC4 (PF02229, IPR003173): Transcriptional Coactivator p15 (PC4)
149	SUMO1	interactor	15	0.352	68.588	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
150	SURF4	interactor	11	0.491	4.851	SURF4 (PF02077, IPR002995): SURF4 family
151	SUZ12	suppressor	51	0.378	211.623	DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
152	SYNCRIP	interactor	44	0.485	152.126	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
153	TADA2A	interactor	23	0.435	54.056	SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
154	TCERG1	interactor	20	0.521	14.114	FF (PF01846, IPR002713, SM00441): FF domain WW (PF00397, IPR001202, SM00456): WW domain Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807) DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886) Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO FAM150 (PF15129, IPR029364): FAM150 family
155	TMEM43	interactor	3	1.000	0	TMEM43 (PF07787, IPR012430): Transmembrane protein 43 UPF0697 (PF15117, IPR029368): Uncharacterised protein family UPF0697
156	TOMM20	interactor	5	0.500	1.653	RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate MAS20 (PF02064, IPR002056): MAS20 protein import receptor
157	TOP1	oncoprotein	41	0.535	58.331	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor Sox_N (PF12444, IPR022151): Sox developmental protein N terminal Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) TonB_N (PF16031): TonB N-terminal region
158	TP53	suppressor	54	0.279	479.967	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
159	TP53BP1	suppressor	14	0.374	18.092	53-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
160	TRA2B	interactor	42	0.460	120.289	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
161	TRAF2	interactor	15	0.330	63.124	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
162	TRAF3IP2	interactor	6	0.800	1.106	SEFIR (PF08357, IPR013568): SEFIR domain Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
163	TRAF5	interactor	7	0.733	2.242	Sina (PF03145, IPR018121): Seven in absentia protein family zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal Spc29 (PF17082, IPR031392): Spindle Pole Component 29
164	TRIM55	interactor	17	0.417	42.857	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein NABP (PF07990, IPR012940): Nucleic acid binding protein NABP zf-HIT (PF04438, IPR007529): HIT zinc finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
165	TRMT112	interactor	17	0.463	9.033	Trm112p (PF03966, IPR005651): Trm112p-like protein
166	U2AF1	oncoprotein	49	0.451	162.299	DUF1509 (PF07420, IPR010883): Protein of unknown function (DUF1509) KMP11 (PF03037, IPR004132): Kinetoplastid membrane protein 11 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
167	U2AF2	protein found in more fusions	74	0.452	290.901	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
168	UBC	protein found in more fusions	47	0.360	373.002	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
169	UBE2I	interactor	38	0.264	489.534	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
170	UBR5	protein found in more fusions	11	0.378	11.473	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SDA1 (PF05285, IPR007949): SDA1 HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
171	UBXN4	interactor	2	0	5.545	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like UBX (PF00789, IPR001012, SM00166): UBX domain Thioredoxin_7 (PF13899): Thioredoxin-like
172	UTP14A	interactor	23	0.411	25.540	Utp14 (PF04615, IPR006709): Utp14 protein
173	VASN	interactor	9	0.528	1.794	EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain TraW_N (PF12477, IPR025864): Sex factor F TraW protein N terminal LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
174	VTN	interactor	26	0.505	24.187	Hemopexin (PF00045, IPR018487, SM00120): Hemopexin Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain
175	WDR18	interactor	21	0.429	29.387	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 WD40_alt (PF14077, IPR026987): Alternative WD40 repeat motif
176	XBP1	protein found in more fusions	5	0.667	0.425	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper DUF2630 (PF10944, IPR020311): Protein of unknown function (DUF2630)
177	XPO1	interactor	43	0.274	273.156	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
178	YME1L1	interactor	2	0	4.754	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
179	YWHAE	oncoprotein	28	0.489	31.784	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
180	YWHAQ	interactor	28	0.484	36.618	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
181	ZBTB1	interactor	10	0.400	5.934	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-BED (PF02892, IPR003656, SM00614): BED zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
182	ZBTB24	interactor	1	0	0	AT_hook (PF02178, IPR017956, SM00384): AT hook motif BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zinc_ribbon_4 (PF13717): zinc-ribbon domain
183	ZMYND11	suppressor	17	0.325	44.726	DUF1002 (PF06207, IPR009343): Protein of unknown function (DUF1002) DUF1353 (PF07087, IPR010767): Protein of unknown function (DUF1353) PWWP (PF00855, IPR000313, SM00293): PWWP domain zf-MYND (PF01753, IPR002893): MYND finger zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box) Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
184	ZNF326	interactor	15	0.571	19.677	AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95) DUF678 (PF05077, IPR007769): Protein of unknown function (DUF678) PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated

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