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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)169
The number (and %) of the onco-proteins69 (40.83 %)
The number (and %) of the tumor suppressors30 (17.75 %)
Total number of binary PPIs (saturation %)1671 (11.77 %)
The number (and %) of affected PPIs167 (9.99 %)
The number of possible different fusions47
PPI diameter5
PPI radius3
The average degree of PPI18.769
Assortativity coefficient-0.1240
The network average Clustering coefficient0.493
The number (and %) of a zero Clustering coefficients5 (2.96 %)
The number (and %) of a zero Betweenness Centrality21 (12.43 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: EBF3,PKM All fusions
Proteins found in more fusions HLA-DRB5/HLA-DRB1 (see 1 fusions); STAU1 (see 2 fusions); EEF1A1 (see 6 fusions); U2AF2 (see 2 fusions); NPM1 (see 1 fusions); PKM/RAC1 (see 1 fusions); CUL7 (see 2 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); RAC1 (see 2 fusions); GAPDH/CDKN1A (see 1 fusions); EWSR1 (see 1 fusions); CCDC88A (see 3 fusions); NAGK (see 1 fusions); COPS5 (see 1 fusions); HDAC5 (see 1 fusions); EP300 (see 1 fusions); PRDX6 (see 2 fusions); HSP90AA1/TUBB (see 1 fusions); PKM/FUS (see 1 fusions); SUZ12 (see 2 fusions); HSPB1/OBSL1 (see 1 fusions); EP300/ETS1 (see 1 fusions); APP (see 5 fusions); VCP (see 4 fusions); TKT (see 5 fusions); HSP90AA1 (see 6 fusions); HSP90AA1/PSMA3 (see 1 fusions); PFKL (see 2 fusions); EIF4A3/IPO11 (see 1 fusions); HUWE1 (see 4 fusions); HSP90AB1 (see 3 fusions); HERC1 (see 3 fusions); EEF1D (see 8 fusions); HNRNPD (see 1 fusions); LNX1 (see 1 fusions); MCM2 (see 1 fusions); ALDOA (see 2 fusions); HSPB1 (see 1 fusions); PFKM (see 1 fusions); NLK (see 4 fusions); EZH2 (see 1 fusions); FGFR1 (see 2 fusions); CDC37 (see 2 fusions); PML (see 4 fusions); GAPDH (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 EBF3parental protein40.167343.439TIG (PF01833, IPR002909): IPT/TIG domain
COE1_DBD (PF16422, IPR032200): Transcription factor COE1 DNA-binding domain
COE1_HLH (PF16423, IPR032201): Transcription factor COE1 helix-loop-helix domain
2 PKMparental protein1630.10613735.139PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
3 ACAT2interactor70.4003.324Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 AGLinteractor70.9520.083GDE_C (PF06202, IPR010401): Amylo-alpha-1,6-glucosidase
hGDE_N (PF14699, IPR029436): N-terminal domain from the human glycogen debranching enzyme
hDGE_amylase (PF14701, IPR032792): Glycogen debranching enzyme, glucanotransferase domain
hGDE_central (PF14702, IPR032788): Central domain of human glycogen debranching enzyme
5 AKR1A1interactor90.6392.896Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
6 ALDH5A1interactor21.0000Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
7 ALDOAprotein found in more fusions320.42485.681Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
8 AMDHD2interactor100Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family
9 ANP32Asuppressor80.6793.123SDA1 (PF05285, IPR007949): SDA1
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_9 (PF14580): Leucine-rich repeat
10 ANXA7suppressor110.32717.239Annexin (PF00191, IPR018502, SM00335): Annexin
11 APPprotein found in more fusions430.202501.289APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
12 ARAFoncoprotein80.5713.836Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
13 ARRB1interactor150.53327.081Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
14 ARRB2interactor220.45532.375Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
15 ASS1suppressor170.39226.992Arginosuc_synth (PF00764, IPR001518): Arginosuccinate synthase
16 ATF2oncoprotein230.30387.945bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
17 BANF1interactor40.6670.500BAF (PF02961, IPR004122, SM01023): Barrier to autointegration factor
18 BAXsuppressor70.4671.961Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
19 C9orf64interactor30.6670.200Q_salvage (PF10343, IPR019438): Potential Queuosine, Q, salvage protein family
20 CAPZA2interactor120.34823.724F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
21 CBSinteractor120.61810.483CBS (PF00571, IPR000644, SM00116): CBS domain
DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414)
PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
22 CCDC8interactor240.44346.461Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
23 CCDC88Aprotein found in more fusions50.6670.486bZIP_1 (PF00170, IPR004827): bZIP transcription factor
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
HOOK (PF05622, IPR008636): HOOK protein
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
24 CD81interactor210.44724.457Tetraspannin (PF00335, IPR018499): Tetraspanin family
25 CDC37protein found in more fusions240.42351.206CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
26 CDK16oncoprotein40.6670.287Pkinase (PF00069, IPR000719): Protein kinase domain
27 CDK2suppressor450.296337.786Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
28 CDK4oncoprotein180.43825.774Pkinase (PF00069, IPR000719): Protein kinase domain
29 CDKN1Asuppressor200.51641.095CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
30 CFL1interactor400.301243.184Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
31 COPS5protein found in more fusions430.359220.631JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
32 CRY1interactor120.5455.729DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
33 CTPS1interactor140.5903.915CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
34 CUL1suppressor420.367223.466Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
35 CUL2suppressor300.45362.037Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
36 CUL3protein found in more fusions540.288410.435Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
37 CUL5suppressor310.46075.981Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
38 CUL7protein found in more fusions400.312223.505ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
39 DAZAP1interactor240.33768.807RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
40 DDB2suppressor90.3219.824WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
41 DNAJA3suppressor70.6672.004DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
42 EEF1A1suppressor600.268579.214GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
43 EEF1A2oncoprotein180.32728.341GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
44 EEF1Dprotein found in more fusions290.376109.381EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
45 EGLN1suppressor41.0000zf-MYND (PF01753, IPR002893): MYND finger
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
46 EGLN3suppressor50.6671.5002OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
47 EIF4A3protein found in more fusions280.373134.979DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
48 ENO3interactor80.6074.802Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
49 EP300oncoprotein230.299117.573Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
50 EPM2Ainteractor200CBM_20 (PF00686, IPR002044): Starch binding domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
51 ETS1oncoprotein70.52411.017Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
52 EWSR1oncoprotein360.375167.280RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
53 EXOSC5interactor30.6670.118RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
54 EZH2suppressor200.37445.868CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
55 FAM49Binteractor21.0000DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394)
56 FBXO6interactor320.345104.366FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
57 FBXW7suppressor110.311260.377Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
58 FGFR1oncoprotein31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
59 FHsuppressor150.39039.928Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
60 FN1oncoprotein480.257305.315fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
61 FOXC2oncoprotein200Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
62 FUBP1oncoprotein180.39220.071DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
63 FUSsuppressor390.468108.487Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
64 GAPDHoncoprotein540.319323.284Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
65 GNG12interactor21.0000G-gamma (PF00631, IPR015898, SM00224): GGL domain
66 GRB7interactor21.0000BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
67 H2AFXsuppressor200.44724.543Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
68 HDAC5protein found in more fusions240.38737.108Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
69 HDAC6oncoprotein210.32659.719Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
70 HERC1protein found in more fusions31.0000Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Presenilin (PF01080, IPR001108): Presenilin
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
SPRY (PF00622, IPR003877, SM00449): SPRY domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
71 HIF1Asuppressor170.36087.184Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
72 HLA-DRAinteractor51.0000MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
73 HLA-DRB1protein found in more fusions80.7622.500DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
74 HLA-DRB3interactor41.0000DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
75 HLA-DRB4interactor31.0000DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
76 HLA-DRB5protein found in more fusions51.0000MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
77 HNRNPA1interactor450.453104.578RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
78 HNRNPDoncoprotein330.38597.005CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
79 HNRNPKoncoprotein400.397130.199ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
80 HSP90AA1oncoprotein630.253852.629HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
81 HSP90AB1oncoprotein530.296364.280HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
82 HSPB1oncoprotein330.37998.495HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
83 HUWE1oncoprotein340.362107.068BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
84 IGSF8oncoprotein150.41917.954V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
85 IKBKAPinteractor70.4003.530IKI3 (PF04762, IPR006849): IKI3 family
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
MMU163 (PF17119, IPR031342): Mitochondrial protein up-regulated during meiosis
86 IPO11protein found in more fusions80.5005.438DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
HEAT_2 (PF13646): HEAT repeats
87 IQCB1interactor170.41246.321DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
88 ISG15suppressor170.41922.044ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
89 ITGA4interactor380.315146.769FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
90 JUNoncoprotein190.288430.781bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
91 LDHAinteractor360.380125.587Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
92 LDHAL6Ainteractor30.6670.500Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
93 LDHBinteractor260.41748.745Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
94 LMO7oncoprotein60.6001.733CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF2072 (PF09845, IPR018645): Zn-ribbon containing protein
AAA_23 (PF13476): AAA domain
DUF4757 (PF15949, IPR031865): Domain of unknown function (DUF4757)
95 LNX1protein found in more fusions100.36116.660PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
96 LYPLA2interactor60.8000.493Abhydrolase_2 (PF02230, IPR003140): Phospholipase/Carboxylesterase
97 MAPK7oncoprotein130.50018.311Pkinase (PF00069, IPR000719): Protein kinase domain
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
98 MCM2oncoprotein550.335297.148AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
99 MCM5oncoprotein240.46740.833MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
100 MDM2oncoprotein330.345156.553Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
101 ME1interactor21.0000malic (PF00390, IPR012301): Malic enzyme, N-terminal domain
Malic_M (PF03949, IPR012302, SM00919): Malic enzyme, NAD binding domain
102 MGMTinteractor90.6942.392DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain
Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
103 MPGinteractor40.6671.145Pur_DNA_glyco (PF02245, IPR003180): Methylpurine-DNA glycosylase (MPG)
104 MYOCinteractor90.6791.777IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
105 NAGKprotein found in more fusions40.6670.667BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
106 NANSinteractor110.45510.932NeuB (PF03102, IPR013132): NeuB family
SAF (PF08666, IPR013974, SM00858): SAF domain
107 NDRG1suppressor80.5006.703Ndr (PF03096, IPR004142): Ndr family
108 NLKprotein found in more fusions41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
109 NPLOC4interactor160.45031.898NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
110 NPM1suppressor510.338281.367Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
111 NTRK1oncoprotein710.241901.409I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
112 NXT2interactor31.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
113 OBSL1protein found in more fusions300.41457.186BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
114 PAICSinteractor200.43933.358AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
115 PAN2interactor140.34134.770RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
116 PAX8oncoprotein30.6670.585PAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Pax2_C (PF12403, IPR022130): Paired-box protein 2 C terminal
117 PCBP1oncoprotein420.318245.071Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
118 PDLIM5interactor130.57714.008LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
119 PFKLprotein found in more fusions160.43815.055PFK (PF00365, IPR000023): Phosphofructokinase
120 PFKMprotein found in more fusions100.6114.322PFK (PF00365, IPR000023): Phosphofructokinase
121 PFKPinteractor190.42725.438PFK (PF00365, IPR000023): Phosphofructokinase
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
122 PGK1interactor330.44986.879PGK (PF00162, IPR001576): Phosphoglycerate kinase
123 PIN1suppressor150.33359.093Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
124 PLIN3interactor130.56113.429Perilipin (PF03036, IPR004279): Perilipin family
125 PMLsuppressor190.37950.910zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
126 POLE2interactor21.0000DNA_pol_E_B (PF04042, IPR007185): DNA polymerase alpha/epsilon subunit B
Dpoe2NT (PF12213, IPR024639): DNA polymerases epsilon N terminal
127 PPIDinteractor100.7333.043Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
128 PPME1interactor80.7140.816Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
129 PPP1CAsuppressor170.27223.531Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
130 PRDX2interactor240.37359.947AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
131 PRDX6protein found in more fusions190.34023.928AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
132 PSMA3protein found in more fusions290.42689.286Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
133 PTENsuppressor110.25533.080DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
134 RAB10oncoprotein90.6111.918Ras (PF00071, IPR001806, SM00173): Ras family
135 RAC1oncoprotein70.7330.503Ras (PF00071, IPR001806, SM00173): Ras family
136 RAD23Bsuppressor170.35354.947K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
137 RAF1oncoprotein130.45510.965Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
138 RAP1Boncoprotein40.6670.254Ras (PF00071, IPR001806, SM00173): Ras family
139 RCC1interactor70.5711.542RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
140 RELAoncoprotein180.40444.030DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
141 RNF185interactor50.5001.452zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
142 RPN1oncoprotein130.44913.339Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
143 RPP14interactor100RNase_P_Rpp14 (PF01900, IPR002759): Rpp14/Pop5 family
144 SHBGoncoprotein31.0000Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
145 SLC3A2interactor110.6003.372Alpha-amylase (PF00128, IPR006047): Alpha amylase, catalytic domain
DUF3459 (PF11941, IPR022567): Domain of unknown function (DUF3459)
SLC3A2_N (PF16028, IPR031984): Solute carrier family 3 member 2 N-terminus
146 SMN1interactor130.5458.956SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
147 SRP14interactor160.35833.075SRP14 (PF02290, IPR003210): Signal recognition particle 14kD protein
148 STAU1protein found in more fusions280.45640.763dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
149 SUMO1interactor120.45525.301Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
150 SUZ12suppressor190.32050.072DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
151 TERF1interactor220.36746.446TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
152 TINF2interactor90.5711.704TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
153 TK1oncoprotein90.5713.083TK (PF00265, IPR001267, SM00203): Thymidine kinase
154 TKTprotein found in more fusions360.334159.701Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
155 TRAF3IP1interactor80.6791.278MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
156 TRAP1oncoprotein200.35842.333HSP90 (PF00183, IPR001404): Hsp90 protein
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
157 TRIM35suppressor21.0000SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3410 (PF11890, IPR024531): Domain of unknown function (DUF3410)
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
158 TRIM63interactor70.4675.187DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
KIP1 (PF07765, IPR011684): KIP1-like protein
RED_C (PF07807, IPR012492): RED-like protein C-terminal region
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
YceG_bac (PF14266, IPR025647): Putative component of 'biosynthetic module'
159 TUBA4Ainteractor220.39839.069Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
160 TUBBprotein found in more fusions400.341154.146Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
161 TWF2interactor30.6671.000Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
162 U2AF2protein found in more fusions390.413111.356RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
163 UBA2interactor110.58211.912ThiF (PF00899, IPR000594): ThiF family
UAE_UbL (PF14732, IPR028077): Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
164 UCHL5oncoprotein140.37221.137Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
165 UFM1interactor80.3939.215Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
166 USP7oncoprotein240.265404.121MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
167 VCPprotein found in more fusions520.302348.607AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
168 YWHAQinteractor420.367195.88814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
169 ZNF423oncoprotein2020.313zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zinc_ribbon_9 (PF14369): zinc-ribbon
Zf_RING (PF16744, IPR031946): KIAA1045 RING finger

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