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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)50
The number (and %) of the onco-proteins8 (16.00 %)
The number (and %) of the tumor suppressors4 (8.00 %)
Total number of binary PPIs (saturation %)78 (6.37 %)
The number (and %) of affected PPIs49 (62.82 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI2.680
Assortativity coefficient-0.4341
The network average Clustering coefficient0.227
The number (and %) of a zero Clustering coefficients33 (66.00 %)
The number (and %) of a zero Betweenness Centrality32 (64.00 %)

ACTIVE INTERACTORS


List of the fusions
PPI for parental proteins: PKD2,C16orf70 All fusions
Proteins found in more fusions ZBTB16 (see 4 fusions); PKD1 (see 1 fusions); APP (see 5 fusions); SERPINB4/SERPINB3 (see 6 fusions); PPFIA1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient		 Betweenness
Centrality		 Domains (Pfam, InterPro, SMART): description
1 PKD2parental protein200.0181025.105Ion_trans (PF00520, IPR005821): Ion transport protein
PKD_channel (PF08016, IPR013122): Polycystin cation channel
Tetraspannin (PF00335, IPR018499): Tetraspanin family
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
2 C16orf70parental protein290.0151650.348UPF0183 (PF03676, IPR005373): Uncharacterised protein family (UPF0183)
3 ALG5interactor100Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
4 ANK3interactor100BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Death (PF00531, IPR000488, SM00005): Death domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
DUF3008 (PF11450, IPR021553): Protein of unknwon function (DUF3008)
DUF3439 (PF11921, IPR024592): Domain of unknown function (DUF3439)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
5 APPprotein found in more fusions50.333135.405APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 APPL1interactor200ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
PH (PF00169, IPR001849, SM00233): PH domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
BAR_3 (PF16746): BAR domain of APPL family
7 ATP1A1interactor21.0000Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
8 ATXN3interactor50.167179.519Josephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
9 BCAS3oncoprotein21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
BCAS3 (PF12490, IPR022175): Breast carcinoma amplified sequence 3
10 BCAS4oncoprotein100NA
11 CALML3interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
12 CALML5interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
13 CANXinteractor30171.452Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
14 CELA2Binteractor2075.476Trypsin (PF00089, IPR001254, SM00020): Trypsin
15 CEP170interactor2080.476FHA (PF00498, IPR000253, SM00240): FHA domain
DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254)
CEP170_C (PF15308, IPR029300): CEP170 C-terminus
16 CST6suppressor100Cystatin (PF00031, IPR000010, SM00043): Cystatin domain
17 FAM3Dinteractor100ILEI (PF15711): Interleukin-like EMT inducer
18 FBXO30interactor100zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C2H2_4 (PF13894): C2H2-type zinc finger
DUF4644 (PF15486, IPR027978): Domain of unknown function (DUF4644)
zf-TRAF_2 (PF15965, IPR001293): TRAF-like zinc-finger
F-box_4 (PF15966, IPR001810): F-box
19 GLRA2interactor2080.476Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
20 GM2Ainteractor100E1_DerP2_DerF2 (PF02221, IPR003172, SM00737): ML domain
21 GOLGA2interactor2059.210ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
22 KRT40interactor30141.686Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
23 KRTAP10-3interactor40.66710.595Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
24 KRTAP10-8interactor31.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
25 MAGEA8interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
26 MASTLinteractor100Pkinase (PF00069, IPR000719): Protein kinase domain
27 NEFHinteractor21.0000DUF1388 (PF07142, IPR010790): Repeat of unknown function (DUF1388)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Filament (PF00038, IPR001664): Intermediate filament protein
28 NEFLinteractor30.6674.619Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
NOA36 (PF06524, IPR010531): NOA36 protein
BORG_CEP (PF14957, IPR029273): Cdc42 effector
29 NUP35interactor20100.643Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif
30 OCRLinteractor20100.643Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
OCRL_clath_bd (PF16726, IPR031995): Inositol polyphosphate 5-phosphatase clathrin binding domain
31 PICK1oncoprotein2064.643Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
32 PKD1suppressor31.0000Stress-antifung (PF01657, IPR002902): Salt stress response/antifungal
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
PKD (PF00801, IPR000601, SM00089): PKD domain
PKD_channel (PF08016, IPR013122): Polycystin cation channel
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
REJ (PF02010, IPR002859): REJ domain
WSC (PF01822, IPR002889, SM00321): WSC domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
fn3_3 (PF14686, IPR029413): Polysaccharide lyase family 4, domain II
33 PLSCR1interactor40.167221.757Scramblase (PF03803, IPR005552): Scramblase
34 POF1Binteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
35 POMPinteractor40.333100.210UMP1 (PF05348, IPR008012): Proteasome maturation factor UMP1
36 PPFIA1protein found in more fusions200HWE_HK (PF07536, IPR011102, SM00911): HWE histidine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Cluap1 (PF10234, IPR019366): Clusterin-associated protein-1
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
TSNAXIP1_N (PF15739, IPR032755): Translin-associated factor X-interacting N-terminus
FAM76 (PF16046, IPR032017): FAM76 protein
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
37 PSMG2interactor21.0000PAC2 (PF09754, IPR019151): PAC2 family
38 S100A7oncoprotein100S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
39 SBSNinteractor100ApoLp-III (PF07464, IPR010009): Apolipophorin-III precursor (apoLp-III)
Cecropin (PF00272, IPR000875): Cecropin family
Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
DUF3789 (PF12664, IPR024522): Protein of unknown function (DUF3789)
40 SERPINA3interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
41 SERPINB3oncoprotein21.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
42 SERPINB4oncoprotein21.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
43 SERPINB6interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
44 SRPRAinteractor100SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
SRP54 (PF00448, IPR000897, SM00962): SRP54-type protein, GTPase domain
SRP54_N (PF02881, IPR013822, SM00963): SRP54-type protein, helical bundle domain
45 TGM3suppressor100Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
46 TMEM248interactor100TMEM219 (PF14940): Transmembrane 219
47 TNNI3interactor100Troponin (PF00992, IPR001978): Troponin
Troponin-I_N (PF11636, IPR021666): Troponin I residues 1-32
48 TRPC1interactor200Ion_trans (PF00520, IPR005821): Ion transport protein
TRP_2 (PF08344, IPR013555): Transient receptor ion channel II
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
49 WIPI2interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
50 ZBTB16suppressor50279.738BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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