Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PITX1, PCNP (from a repository: Mon Dec 9 13:16:31 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 45 The number (and %) of the onco-proteins 12 (26.67 %) The number (and %) of the tumor suppressors 5 (11.11 %) Total number of binary PPIs (saturation %) 117 (11.82 %) The number (and %) of affected PPIs 43 (36.75 %) The number of possible different fusions 10 PPI diameter 5 PPI radius 3 The average degree of PPI 4.267 Assortativity coefficient -0.4335 The network average Clustering coefficient 0.387 The number (and %) of a zero Clustering coefficients 14 (31.11 %) The number (and %) of a zero Betweenness Centrality 15 (33.33 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PCNP,PITX1	All fusions
Proteins found in more fusions	TERF2IP (see 1 fusions); USP11 (see 4 fusions); DVL3 (see 1 fusions); HUWE1 (see 2 fusions); EWSR1 (see 2 fusions); LMNA (see 3 fusions); MAGED1 (see 1 fusions); SMAD3 (see 3 fusions); RBPMS (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PCNP	parental protein	16	0.117	480.861	PCNP (PF15473, IPR029169): PEST, proteolytic signal-containing nuclear protein family
2	PITX1	parental protein	27	0.063	1075.886	Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region OAR (PF03826, IPR003654): OAR domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
3	ALG13	interactor	1	0	0	Glyco_tran_28_C (PF04101, IPR007235): Glycosyltransferase family 28 C-terminal domain OTU (PF02338, IPR003323): OTU-like cysteine protease SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
4	BMI1	oncoprotein	7	0.333	85.013	zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
5	C1orf94	interactor	5	0.833	0.667	DUF4688 (PF15752, IPR031496): Domain of unknown function (DUF4688)
6	CAND1	interactor	7	0.467	55.287	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
7	CDX4	interactor	1	0	0	Caudal_act (PF04731, IPR006820): Caudal like protein activation region Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
8	DVL3	protein found in more fusions	5	0.500	56.795	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
9	EGR1	suppressor	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DUF3432 (PF11914, IPR021839): Domain of unknown function (DUF3432) DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
10	ELAVL1	oncoprotein	10	0.194	212.674	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11	EMC2	interactor	2	1.000	0	TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_19 (PF14559): Tetratricopeptide repeat Alkyl_sulf_dimr (PF14863, IPR029228): Alkyl sulfatase dimerisation
12	EWSR1	oncoprotein	8	0.286	188.356	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
13	HGS	interactor	4	0.167	108.536	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate PIEZO (PF15917, IPR031805): Piezo
14	HIST1H3E	interactor	2	1.000	0	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
15	HUWE1	oncoprotein	4	0.333	28.079	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
16	IPO13	interactor	2	0	26.956	IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein
17	LMNA	protein found in more fusions	5	0.500	13.580	Filament (PF00038, IPR001664): Intermediate filament protein LTD (PF00932, IPR001322): Lamin Tail Domain Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
18	LZTS2	suppressor	4	0.667	8.238	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127) Fez1 (PF06818): Fez1 ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
19	MAGED1	protein found in more fusions	5	0.833	0.667	MAGE (PF01454, IPR002190): MAGE family
20	MGAT5B	interactor	3	0.667	0.667	Glyco_transf_18 (PF15024): Glycosyltransferase family 18
21	MMGT1	interactor	3	0.667	13.043	MMgT (PF10270, IPR018937): Membrane magnesium transporter
22	MOV10	interactor	5	0.400	42.627	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
23	MYO1C	interactor	1	0	0	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
24	NR5A1	interactor	3	0.667	20.874	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor PRIMA1 (PF16101): Proline-rich membrane anchor 1
25	NXF1	interactor	10	0.194	175.387	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
26	PLSCR1	interactor	3	0.667	4.263	Scramblase (PF03803, IPR005552): Scramblase
27	POU1F1	interactor	1	0	0	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain Lsr2 (PF11774, IPR024412): Lsr2
28	PRR20A	interactor	4	1.000	0	PRR20 (PF15708, IPR031439): Proline-rich protein family 20
29	PTPN1	suppressor	1	0	0	Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
30	RBPMS	protein found in more fusions	10	0.389	39.483	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
31	RFX6	interactor	1	0	0	RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain SapB_1 (PF05184, IPR007856): Saposin-like type B, region 1
32	RHOXF2	interactor	7	0.600	11.925	DUF367 (PF04034, IPR007177): Domain of unknown function (DUF367) GRP (PF07172, IPR010800): Glycine rich protein family Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
33	RNF31	interactor	3	1.000	0	Auto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain PUB (PF09409, IPR018997): PUB domain TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
34	SMAD3	oncoprotein	4	0.667	4.688	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
35	SMARCA2	suppressor	2	0	24.306	DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168) DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain YL1 (PF05764, IPR008895): YL1 nuclear protein BRK (PF07533, IPR006576, SM00592): BRK domain DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
36	SPAG8	interactor	1	0	0	Zip (PF02535, IPR003689): ZIP Zinc transporter
37	TERF2IP	protein found in more fusions	3	0	13.087	BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain Histone_HNS (PF00816, IPR001801): H-NS histone family Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
38	TRAPPC2	interactor	4	0.667	20.874	Sedlin_N (PF04628, IPR006722): Sedlin, N-terminal conserved region
39	TRIM23	interactor	2	0	0	Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family FemAB (PF02388, IPR003447): FemAB family zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
40	UHRF2	suppressor	2	0	0	PHD (PF00628, IPR019787, SM00249): PHD-finger SAD_SRA (PF02182, IPR003105, SM00466): SAD/SRA domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family TTD (PF12148, IPR021991): Tandem tudor domain within UHRF1 zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
41	UPF2	interactor	4	0.667	20.874	DDHD (PF02862, IPR004177, SM01127): DDHD domain DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) MIF4G (PF02854, IPR003890, SM00543): MIF4G domain Upf2 (PF04050, IPR007193): Up-frameshift suppressor 2 MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 SUFU_C (PF12470, IPR024314): Suppressor of Fused Gli/Ci N terminal binding domain
42	USP11	protein found in more fusions	6	0.700	3.601	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase DUSP (PF06337, IPR006615, SM00695): DUSP domain Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
43	XPO1	interactor	9	0.167	241.622	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
44	XRCC3	oncoprotein	2	0	13.087	Rad51 (PF08423, IPR013632): Rad51 RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
45	ZBTB32	interactor	3	1.000	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-met (PF12874): Zinc-finger of C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger

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