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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SERPINA1, ACO1 (from a repository: Fri Nov 27 21:56:09 2020)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)49
The number (and %) of the onco-proteins13 (26.53 %)
The number (and %) of the tumor suppressors3 (6.12 %)
Total number of binary PPIs (saturation %)132 (11.22 %)
The number (and %) of affected PPIs47 (35.61 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI4.735
Assortativity coefficient-0.2091
The network average Clustering coefficient0.306
The number (and %) of a zero Clustering coefficients19 (38.78 %)
The number (and %) of a zero Betweenness Centrality18 (36.73 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ACO1,SERPINA1 All fusions
Proteins found in more fusions APP (see 4 fusions); ECHS1 (see 1 fusions); OS9 (see 2 fusions); SMAD4 (see 2 fusions); VCP (see 4 fusions); SDC2 (see 2 fusions); STRAP (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ACO1parental protein170.103570.763Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
2 SERPINA1parental protein300.0511118.419Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
3 ALDH2oncoprotein3020.709Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
DUF1235 (PF06822, IPR009641): Protein of unknown function (DUF1235)
4 APPprotein found in more fusions90.036134.989APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ATP5C1interactor50.30028.128ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
6 C12orf57interactor100P_C10 (PF14974, IPR026317): Protein C10
7 CA8interactor100Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
8 CANXinteractor30.66710.707Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
9 CTPS1interactor41.0000CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
10 DCPSinteractor50.50020.533DcpS (PF05652, IPR008594): Scavenger mRNA decapping enzyme (DcpS) N-terminal
DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
11 DDX19Binteractor3023.214DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
12 DERL1interactor50.50020.108DER1 (PF04511, IPR007599): Der1-like family
13 DERL2interactor50.7002.639DER1 (PF04511, IPR007599): Der1-like family
14 ECHS1protein found in more fusions60.20052.141ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
15 ELANEinteractor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
16 ENO1oncoprotein40.50017.800Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
17 ERLEC1interactor40.8331.877PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
18 FBXL5interactor200Hemerythrin (PF01814, IPR012312): Hemerythrin HHE cation binding domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
19 FBXO2interactor21.0000FBA (PF04300, IPR007397): F-box associated region
F-box (PF00646, IPR001810, SM00256): F-box domain
20 FN1oncoprotein110.200203.577fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
21 FUBP1oncoprotein40.50017.276DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
22 GBE1interactor100Alpha-amylase (PF00128, IPR006047): Alpha amylase, catalytic domain
CBM_48 (PF02922, IPR004193): Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
Alpha-amylase_C (PF02806, IPR006048, SM00632): Alpha amylase, C-terminal all-beta domain
23 GDPD1interactor100GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
24 GSDMBinteractor208.660Gasdermin (PF04598, IPR007677): Gasdermin family
25 HIST1H2ABinteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
26 HSPA5oncoprotein150.209231.612HSP70 (PF00012, IPR013126): Hsp70 protein
27 ICE2interactor100NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
28 KLK3interactor31.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
29 LAMTOR5interactor40.50021.795LAMTOR5 (PF16672, IPR024135): Ragulator complex protein LAMTOR5
30 LGALS1interactor60.33350.377Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
31 MIS12interactor100DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
Mis12 (PF05859, IPR008685): Mis12 protein
32 MOV10interactor80.21478.264AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
33 NTRK1oncoprotein160.181273.662I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
34 NXF1interactor80.09570.396NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
35 OS9protein found in more fusions60.8002.377DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
36 PLK2suppressor208.660Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
37 PRTN3interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
38 PSMG1interactor40.66714.270PAC1 (PF16094, IPR016565): Proteasome assembly chaperone 4
39 RAP2Aoncoprotein4038.020Ras (PF00071, IPR001806, SM00173): Ras family
40 RCHY1suppressor200C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
41 SDC2protein found in more fusions31.0000Glycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
42 SHMT2interactor50.30028.596SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
43 SMAD4suppressor31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
44 SSR1interactor40.66711.374TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
45 STRAPprotein found in more fusions60.6005.057WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
46 TXNDC17interactor100DUF953 (PF06110, IPR010357): Eukaryotic protein of unknown function (DUF953)
Glutaredoxin (PF00462, IPR002109): Glutaredoxin
47 VCPprotein found in more fusions100.36188.207AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
48 VKORC1interactor200VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family
49 ZNF558interactor3021.795KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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