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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ND2, SERPINA1 (from a repository: Mon May 15 17:10:51 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)38
The number (and %) of the onco-proteins9 (23.68 %)
The number (and %) of the tumor suppressors4 (10.53 %)
Total number of binary PPIs (saturation %)71 (10.10 %)
The number (and %) of affected PPIs36 (50.70 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI3.211
Assortativity coefficient-0.2817
The network average Clustering coefficient0.378
The number (and %) of a zero Clustering coefficients18 (47.37 %)
The number (and %) of a zero Betweenness Centrality26 (68.42 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ND2,SERPINA1 All fusions
Proteins found in more fusions VCP (see 4 fusions); SDC2 (see 2 fusions); ECHS1 (see 1 fusions); OS9 (see 2 fusions); SMAD4 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ND2parental protein60.133335.000NA
2 SERPINA1parental protein300.0511095.833Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
3 ALDH2oncoprotein100Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
DUF1235 (PF06822, IPR009641): Protein of unknown function (DUF1235)
4 ATP5C1interactor30.6670.667ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
5 CA8interactor100Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
6 CANXinteractor21.0000Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
7 DDX19Binteractor100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
8 DERL1interactor41.0000DER1 (PF04511, IPR007599): Der1-like family
9 DERL2interactor50.70012.667DER1 (PF04511, IPR007599): Der1-like family
10 ECHS1protein found in more fusions200ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
11 ELANEinteractor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
12 ERLEC1interactor50.500420.500PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
13 FBXO2interactor21.0000FBA (PF04300, IPR007397): F-box associated region
F-box (PF00646, IPR001810, SM00256): F-box domain
14 FN1oncoprotein70.38112.333fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
15 GDPD1interactor100GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
16 GRIN1interactor100ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
CaM_bdg_C0 (PF10562, IPR018882): Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
17 GSDMBinteractor100Gasdermin (PF04598, IPR007677): Gasdermin family
18 HSPA5oncoprotein90.39347.000HSP70 (PF00012, IPR013126): Hsp70 protein
19 ICE2interactor100NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
20 KLK3interactor31.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
21 LAMTOR5interactor21.0000LAMTOR5 (PF16672, IPR024135): Ragulator complex protein LAMTOR5
22 MIS12interactor100DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
Mis12 (PF05859, IPR008685): Mis12 protein
23 NDUFA11interactor21.00007kD_coat (PF02495, IPR003411): 7kD viral coat protein
Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
24 OS9protein found in more fusions60.8004.500DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
25 PLK2suppressor100Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
26 PRTN3interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
27 RAP2Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
28 RCHY1suppressor200C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
29 SDC2protein found in more fusions31.0000Glycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
30 SMAD4suppressor31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
31 SRConcoprotein200Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
32 SSR1interactor30.6670.667TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
33 STK11suppressor20372.000Pkinase (PF00069, IPR000719): Protein kinase domain
34 TIMMDC1interactor21.0000Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
35 VCPprotein found in more fusions90.39315.833AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
36 VKORC1interactor200VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family
37 YME1L1interactor30.6671.000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
38 ZNF558interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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