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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)70
The number (and %) of the onco-proteins23 (32.86 %)
The number (and %) of the tumor suppressors7 (10.00 %)
Total number of binary PPIs (saturation %)198 (8.20 %)
The number (and %) of affected PPIs69 (34.85 %)
The number of possible different fusions16
PPI diameter5
PPI radius3
The average degree of PPI4.971
Assortativity coefficient-0.3051
The network average Clustering coefficient0.328
The number (and %) of a zero Clustering coefficients27 (38.57 %)
The number (and %) of a zero Betweenness Centrality25 (35.71 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LIMK1,SERPINA1 All fusions
Proteins found in more fusions APP (see 4 fusions); ECHS1 (see 1 fusions); OS9 (see 2 fusions); SMAD4 (see 2 fusions); VCP (see 4 fusions); SDC2 (see 2 fusions); ERBIN (see 4 fusions); FYN (see 1 fusions); PAK4 (see 1 fusions); HSP90AA1 (see 5 fusions); YWHAZ (see 3 fusions); MAPK14 (see 1 fusions); LIMK1 (see 1 fusions); BRAF (see 3 fusions); PAK1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LIMK1parental protein390.0702072.493LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
2 SERPINA1parental protein300.0511404.221Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
3 ALDH2oncoprotein2025.763Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
DUF1235 (PF06822, IPR009641): Protein of unknown function (DUF1235)
4 APPprotein found in more fusions200.123619.416APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ARRB1interactor80.42965.426Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
6 ARRB2interactor70.47683.047Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
7 ATP5C1interactor50.30049.555ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
8 BADoncoprotein50.60024.277Bcl-2_BAD (PF10514, IPR018868): Pro-apoptotic Bcl-2 protein, BAD
9 BLMHinteractor31.0000Peptidase_C1_2 (PF03051, IPR004134): Peptidase C1-like family
10 BMPR2suppressor200Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Cadherin_C_2 (PF16492, IPR032455): Cadherin cytoplasmic C-terminal
11 BRAFoncoprotein60.50025.955Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
12 CA8interactor100Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
13 CANXinteractor40.50032.127Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
14 CDKN1Csuppressor100CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family
TonB_N (PF16031): TonB N-terminal region
15 CFL1interactor60.33335.271Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
16 DDX19Binteractor2025.763DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
17 DERL1interactor50.50044.897DER1 (PF04511, IPR007599): Der1-like family
18 DERL2interactor50.7004.453DER1 (PF04511, IPR007599): Der1-like family
19 ECHS1protein found in more fusions3016.728ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
20 ELANEinteractor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
21 ELAVL1oncoprotein140.115425.242RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
22 ERBINoncoprotein3050.047LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
23 ERLEC1interactor40.8331.131PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
24 FBXO2interactor21.0000FBA (PF04300, IPR007397): F-box associated region
F-box (PF00646, IPR001810, SM00256): F-box domain
25 FN1oncoprotein120.197247.972fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
26 FYNoncoprotein31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
27 GDPD1interactor100GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
28 GSDMBinteractor2025.763Gasdermin (PF04598, IPR007677): Gasdermin family
29 HIST1H1Ainteractor40.5002.874Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
30 HSP90AA1oncoprotein160.238336.865HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
31 HSPA4interactor60.73344.789Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
32 HSPA5oncoprotein150.264336.810HSP70 (PF00012, IPR013126): Hsp70 protein
33 ICE2interactor2013.934NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
34 ITGA1interactor100FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat
LYRIC (PF15686, IPR031402): Lysine-rich CEACAM1 co-isolated protein family
35 KLK3interactor31.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
36 LAMTOR1interactor30.33354.760LAMTOR (PF15454, IPR028209): Late endosomal/lysosomal adaptor and MAPK and MTOR activator
37 LAMTOR5interactor30.33337.743LAMTOR5 (PF16672, IPR024135): Ragulator complex protein LAMTOR5
38 LATS1suppressor21.0000Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
39 LIMK2interactor50.40013.860LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
PP1_inhibitor (PF05361, IPR008025): PKC-activated protein phosphatase-1 inhibitor
40 MAPK14oncoprotein60.4006.342Pkinase (PF00069, IPR000719): Protein kinase domain
41 MAPKAPK2oncoprotein50.5007.224Pkinase (PF00069, IPR000719): Protein kinase domain
42 MBPinteractor30.6671.000Myelin_MBP (PF01669, IPR000548): Myelin basic protein
43 MIIPinteractor100Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
MIIP (PF15734, IPR031466): Migration and invasion-inhibitory
44 MIS12interactor2017.343DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
Mis12 (PF05859, IPR008685): Mis12 protein
45 NRG1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
46 OS9protein found in more fusions60.8002.724DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
47 OSBPL5interactor21.0000Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH (PF00169, IPR001849, SM00233): PH domain
48 PAK1oncoprotein60.7004.469PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
49 PAK4protein found in more fusions60.60010.682PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
50 PARK2suppressor110.46794.154IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
51 PLK2suppressor2025.763Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
52 POLR2Dinteractor21.0000RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4
Tfb4 (PF03850, IPR004600): Transcription factor Tfb4
53 PRTN3interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
54 RAD54Linteractor100Rad54_N (PF08658, IPR013967): Rad54 N terminal
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
55 RAP2Aoncoprotein2013.934Ras (PF00071, IPR001806, SM00173): Ras family
56 RCHY1suppressor200C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
57 RRASoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
58 RTEL1oncoprotein100C1_2 (PF03107, IPR004146): C1 domain
DEAD_2 (PF06733, IPR010614): DEAD_2
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
DZR (PF12773, IPR025874): Double zinc ribbon
Helicase_C_2 (PF13307, IPR006555): Helicase C-terminal domain
CCM2_C (PF16545, IPR032375): Cerebral cavernous malformation protein, harmonin-homology
59 SARNPoncoprotein2013.786SAP (PF02037, IPR003034, SM00513): SAP domain
HTH_Tnp_IS630 (PF01710, IPR002622): Transposase
Prok-E2_A (PF14457, IPR032865): Prokaryotic E2 family A
60 SDC2protein found in more fusions40.66713.934Glycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
61 SH3PXD2Binteractor100PX (PF00787, IPR001683, SM00312): PX domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
62 SMAD4suppressor40.33348.354MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
63 SRPK1interactor60.46723.202FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
64 SSR1interactor40.33317.463TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
65 TADA3interactor100GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF
Ada3 (PF10198, IPR019340): Histone acetyltransferases subunit 3
66 UXTinteractor21.0000Prefoldin (PF02996, IPR004127): Prefoldin subunit
67 VCPprotein found in more fusions160.248366.342AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
68 VKORC1interactor200VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family
69 YWHAZprotein found in more fusions120.236188.10414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
70 ZNF558interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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