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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SERPINA1, RAB38 (from a repository: Fri Nov 27 22:08:29 2020)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)34
The number (and %) of the onco-proteins10 (29.41 %)
The number (and %) of the tumor suppressors3 (8.82 %)
Total number of binary PPIs (saturation %)70 (12.48 %)
The number (and %) of affected PPIs32 (45.71 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI3.529
Assortativity coefficient-0.3545
The network average Clustering coefficient0.325
The number (and %) of a zero Clustering coefficients18 (52.94 %)
The number (and %) of a zero Betweenness Centrality18 (52.94 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RAB38,SERPINA1 All fusions
Proteins found in more fusions VCP (see 4 fusions); SDC2 (see 2 fusions); APP (see 4 fusions); ECHS1 (see 1 fusions); OS9 (see 2 fusions); SMAD4 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RAB38parental protein2064.000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
Ras (PF00071, IPR001806, SM00173): Ras family
2 SERPINA1parental protein300.051873.690Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
3 ALDH2oncoprotein2019.560Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
DUF1235 (PF06822, IPR009641): Protein of unknown function (DUF1235)
4 APPprotein found in more fusions80139.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ATP5C1interactor40.33336.131ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
6 CA8interactor100Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
7 CANXinteractor21.0000Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
8 DDX19Binteractor2019.560DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
9 DERL1interactor50.50036.298DER1 (PF04511, IPR007599): Der1-like family
10 DERL2interactor50.7003.774DER1 (PF04511, IPR007599): Der1-like family
11 ECHS1protein found in more fusions200ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
12 ELANEinteractor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
13 ERLEC1interactor40.8330.500PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
14 FBXO2interactor21.0000FBA (PF04300, IPR007397): F-box associated region
F-box (PF00646, IPR001810, SM00256): F-box domain
15 FN1oncoprotein70.38115.571fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
16 GDPD1interactor100GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
17 GSDMBinteractor2019.560Gasdermin (PF04598, IPR007677): Gasdermin family
18 HSPA5oncoprotein90.39315.500HSP70 (PF00012, IPR013126): Hsp70 protein
19 ICE2interactor100NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
20 KLK3interactor31.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
21 LAMTOR5interactor21.0000LAMTOR5 (PF16672, IPR024135): Ragulator complex protein LAMTOR5
22 MIS12interactor100DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
Mis12 (PF05859, IPR008685): Mis12 protein
23 OS9protein found in more fusions60.8001.000DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
24 PLK2suppressor2019.560Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
25 PRTN3interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
26 RAB32oncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
27 RAP2Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
28 RCHY1suppressor200C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
29 SDC2protein found in more fusions31.0000Glycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
30 SMAD4suppressor31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
31 SSR1interactor30.6671.333TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
32 VCPprotein found in more fusions90.39318.964AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
33 VKORC1interactor200VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family
34 ZNF558interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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