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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PGM3, CACNA1C (from a repository: Sat Aug 17 04:12:39 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)30
The number (and %) of the onco-proteins11 (36.67 %)
The number (and %) of the tumor suppressors3 (10.00 %)
Total number of binary PPIs (saturation %)82 (18.85 %)
The number (and %) of affected PPIs28 (34.15 %)
The number of possible different fusions11
PPI diameter5
PPI radius3
The average degree of PPI4.333
Assortativity coefficient-0.2661
The network average Clustering coefficient0.430
The number (and %) of a zero Clustering coefficients8 (26.67 %)
The number (and %) of a zero Betweenness Centrality12 (40.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CACNA1C,PGM3 All fusions
Proteins found in more fusions VCP (see 4 fusions); RYR2 (see 2 fusions); COPS5 (see 1 fusions); GAN (see 1 fusions); APP (see 5 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); PCBD1 (see 1 fusions); HDAC4 (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CACNA1Cparental protein140.154237.251Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
Ion_trans (PF00520, IPR005821): Ion transport protein
Rer1 (PF03248, IPR004932): Rer1 family
ODV-E18 (PF10717, IPR019655): Occlusion-derived virus envelope protein ODV-E18
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
CAC1F_C (PF16885, IPR031688): Voltage-gated calcium channel subunit alpha, C-term
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
2 PGM3parental protein140.077403.650PGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e
3 APPprotein found in more fusions80.238115.388APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 BAG3oncoprotein31.0000BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
5 CABP1interactor100DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
6 CACNB3interactor100Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
VGCC_beta4Aa_N (PF12052, IPR000584): Voltage gated calcium channel subunit beta domain 4Aa N terminal
7 CALM1interactor50.40042.321EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
8 CAND1interactor70.53332.209Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
9 COPS5protein found in more fusions90.60730.209JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
10 CUL1suppressor90.60723.625Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
11 CUL3protein found in more fusions110.378153.912Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
12 DCP2interactor100DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
13 DERL1interactor40.3339.167DER1 (PF04511, IPR007599): Der1-like family
14 ENOPH1interactor30.6671.000Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
15 GANprotein found in more fusions31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
16 GLO1interactor100Glyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
17 HDAC4oncoprotein40.33331.036Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
18 LACTB2interactor100E2_bind (PF08825, IPR014929): E2 binding domain
Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
Metallophos_3 (PF14582, IPR029461): Metallophosphoesterase, calcineurin superfamily
19 NTRK1oncoprotein80.52465.235I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
20 PCBD1protein found in more fusions60.70016.458Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase
21 PGM1interactor30.6670.750PGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_II (PF02879, IPR005845): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
22 PGM5interactor100PGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_II (PF02879, IPR005845): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
23 PUDPinteractor21.0000Hydrolase_like (PF13242): HAD-hyrolase-like
HAD_2 (PF13419, IPR023214): Haloacid dehalogenase-like hydrolase
24 RYR2protein found in more fusions40.6672.630Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RYDR_ITPR (PF01365, IPR000699): RIH domain
RyR (PF02026, IPR003032): RyR domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
YjfB_motility (PF14070, IPR025906): Putative motility protein
25 SIRT1suppressor31.0000DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
26 SPRTNinteractor3025.701GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term
SprT-like (PF10263, IPR006640, SM00731): SprT-like family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
27 SRIoncoprotein31.0000EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
28 TRIM13suppressor40.6670.750ATP-synt_E_2 (PF08112, IPR012508): ATP synthase epsilon subunit
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
29 UAP1interactor200UDPGP (PF01704, IPR002618): UTP--glucose-1-phosphate uridylyltransferase
30 VCPprotein found in more fusions90.35764.709AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)

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