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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LARGE1, PGM1 (from a repository: Fri Jul 26 08:12:39 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)48
The number (and %) of the onco-proteins13 (27.08 %)
The number (and %) of the tumor suppressors4 (8.33 %)
Total number of binary PPIs (saturation %)200 (17.73 %)
The number (and %) of affected PPIs46 (23.00 %)
The number of possible different fusions7
PPI diameter2
PPI radiusinf
The average degree of PPI7.542
Assortativity coefficient-0.1361
The network average Clustering coefficient0.594
The number (and %) of a zero Clustering coefficients3 (6.25 %)
The number (and %) of a zero Betweenness Centrality12 (25.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LARGE1,PGM1 All fusions
Proteins found in more fusions SORD (see 1 fusions); TERF2IP (see 1 fusions); APP (see 5 fusions); PRDX6 (see 2 fusions); S100B (see 2 fusions); GPI/SORD (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LARGE1parental protein202.000Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
Glyco_transf_49 (PF13896): Glycosyl-transferase for dystroglycan
2 PGM1parental protein440.1431089.134PGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_II (PF02879, IPR005845): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
3 ABATinteractor70.5714.515Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
4 ABHD11interactor31.0000Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
5 ALDH1B1interactor70.6194.486Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
6 ALDH2oncoprotein70.4298.367Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
DUF1235 (PF06822, IPR009641): Protein of unknown function (DUF1235)
7 APPprotein found in more fusions80.28610.486APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
8 ATIConcoprotein30.6670.286AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
9 CATsuppressor90.7144.001Catalase (PF00199, IPR011614, SM01060): Catalase
Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
10 ENO1oncoprotein140.46225.464Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
11 EXOC2interactor21.0000PhzC-PhzF (PF02567, IPR003719): Phenazine biosynthesis-like protein
TIG (PF01833, IPR002909): IPT/TIG domain
Sec5 (PF15469): Exocyst complex component Sec5
12 FAHinteractor41.0000FAA_hydrolase_N (PF09298, IPR015377): Fumarylacetoacetase N-terminal
FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
13 FHsuppressor80.4649.602Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
14 FUBP1oncoprotein21.0000DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
15 FUSsuppressor80.6793.836Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
16 GALK2interactor21.0000GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
GalKase_gal_bdg (PF10509, IPR019539): Galactokinase galactose-binding signature
17 GPD1Linteractor30.6670.333NAD_Gly3P_dh_C (PF07479, IPR006109): NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
NAD_Gly3P_dh_N (PF01210, IPR011128): NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
18 GPIprotein found in more fusions90.5567.401PGI (PF00342, IPR001672): Phosphoglucose isomerase
19 GRHPRinteractor21.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
20 HSPB2interactor50.5001.133Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
21 KYAT3interactor21.0000Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
22 LDHAinteractor220.34380.144Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
23 LDHBinteractor190.41243.677Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
24 LTA4Hinteractor50.4005.167Leuk-A4-hydro_C (PF09127, IPR015211): Leukotriene A4 hydrolase, C-terminal
Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
25 MDH1interactor120.39425.171Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
26 NIT2suppressor70.7621.553CN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
27 NTRK1oncoprotein250.225176.760I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
28 OATinteractor60.5333.652Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
29 PAXIP1interactor60.4004.538BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
30 PGM2interactor80.5365.867PGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_II (PF02879, IPR005845): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
31 PGM3interactor30.6670.400PGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e
32 PLAURoncoprotein100Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
33 POT1interactor90.7143.117POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
34 PRDX6protein found in more fusions110.40018.452AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
35 S100A1interactor31.0000S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
36 S100Boncoprotein31.0000S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
37 SCCPDHinteractor40.6670.800Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
38 SOD1interactor80.7142.815Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
39 SORDprotein found in more fusions130.53014.579ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
40 TALDO1interactor80.6794.465TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
41 TERF1interactor120.6008.924TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
42 TERF2IPprotein found in more fusions80.6193.633BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
43 TINF2interactor80.6195.317TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
44 TMEM25interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4674 (PF15719, IPR029779): Domain of unknown function (DUF4674)
45 TPI1interactor160.40041.041TIM (PF00121, IPR000652): Triosephosphate isomerase
46 UBA5interactor40.6670.667Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
ThiF (PF00899, IPR000594): ThiF family
47 UQCRFS1interactor50.5002.217Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
48 USP4oncoprotein31.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain

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