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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)99
The number (and %) of the onco-proteins33 (33.33 %)
The number (and %) of the tumor suppressors14 (14.14 %)
Total number of binary PPIs (saturation %)589 (12.14 %)
The number (and %) of affected PPIs98 (16.64 %)
The number of possible different fusions21
PPI diameter5
PPI radius3
The average degree of PPI10.909
Assortativity coefficient-0.1412
The network average Clustering coefficient0.562
The number (and %) of a zero Clustering coefficients3 (3.03 %)
The number (and %) of a zero Betweenness Centrality13 (13.13 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CBLB,PEPD All fusions
Proteins found in more fusions TRAF6 (see 1 fusions); PTPN11 (see 1 fusions); SYK (see 1 fusions); RNF11 (see 1 fusions); SOD2 (see 3 fusions); CBL (see 1 fusions); TICAM1 (see 1 fusions); ATXN1 (see 3 fusions); GRB2 (see 1 fusions); LCK (see 1 fusions); FYN (see 1 fusions); CD2AP (see 1 fusions); UBE2D2 (see 2 fusions); SH3KBP1 (see 1 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); SHC1 (see 1 fusions); UBC (see 1 fusions); CBLB (see 4 fusions); NEDD4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CBLBparental protein580.1672168.860Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
PRIMA1 (PF16101): Proline-rich membrane anchor 1
2 PEPDparental protein400.1641641.279AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
DUF3793 (PF12672, IPR024523): Protein of unknown function (DUF3793)
3 ABL1oncoprotein210.453307.686Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
4 APPL1interactor80.8101.708ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
PH (PF00169, IPR001849, SM00233): PH domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
BAR_3 (PF16746): BAR domain of APPL family
5 ARHGEF7interactor60.8674.073Borrelia_lipo_1 (PF05714, IPR008421): Borrelia burgdorferi virulent strain associated lipoprotein
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7
RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7
6 ASAP1interactor70.7147.607ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
BAR_3 (PF16746): BAR domain of APPL family
7 ASS1suppressor160.35251.326Arginosuc_synth (PF00764, IPR001518): Arginosuccinate synthase
8 ATXN1protein found in more fusions60.10077.034AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
9 BCCIPinteractor120.409357.247DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
BCIP (PF13862, IPR025602): p21-C-terminal region-binding protein
10 BTKsuppressor100.6675.925BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
11 CAPN1interactor150.448204.975Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
12 CARD11oncoprotein31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
13 CASP7interactor110.66719.139Peptidase_C14 (PF00656, IPR011600): Caspase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
14 CBLsuppressor380.290507.696Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
15 CD2APprotein found in more fusions71.0000SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
16 CFLARoncoprotein41.0000DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
17 CNDP2suppressor180.418220.965Peptidase_M20 (PF01546, IPR002933): Peptidase family M20/M25/M40
18 CRKoncoprotein180.510263.837SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
19 CRKLoncoprotein160.55873.888SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
20 CRY1interactor40.3332.830DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
21 CTSAinteractor70.6193.686Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
22 CUL2suppressor80.393149.845Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
23 DDR2suppressor31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
TMEM154 (PF15102, IPR028064): TMEM154 protein family
24 DLDinteractor60.60014.409Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
25 DPP3interactor80.39396.402Peptidase_M49 (PF03571): Peptidase family M49
26 EGFRoncoprotein330.339570.551Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
27 EIF4Eoncoprotein50.70011.941IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
28 EIF5Ainteractor70.66712.021EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain
eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
29 EIF6interactor50.8005.117eIF-6 (PF01912, IPR002769, SM00654): eIF-6 family
30 FTOinteractor80.5719.100FTO_NTD (PF12933, IPR024367): FTO catalytic domain
FTO_CTD (PF12934, IPR024366): FTO C-terminal domain
31 FYNoncoprotein180.38281.126Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
32 GBP2interactor100.68910.241GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
33 GDAinteractor80.7504.759Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
34 GINS2interactor80.7862.720Sld5 (PF05916, IPR021151): GINS complex protein
35 GLRX3interactor31.0000Glutaredoxin (PF00462, IPR002109): Glutaredoxin
Thioredoxin (PF00085, IPR013766): Thioredoxin
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
36 GLSinteractor60.8670.733Glutaminase (PF04960, IPR015868): Glutaminase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
37 GNSinteractor130.59020.204Sulfatase (PF00884, IPR000917): Sulfatase
DUF4976 (PF16347, IPR032506): Domain of unknown function (DUF4976)
38 GORASP2interactor2017.137GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
39 GOT1interactor50.30032.100Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
40 GRAP2interactor60.6671.879NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal
SH2 (PF00017, IPR000980, SM00252): SH2 domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
41 GRB2oncoprotein310.377213.778SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
42 GSRinteractor130.59187.513Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
43 HNRNPKoncoprotein140.308144.273ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
44 HSPE1interactor50.30086.271Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
45 IPO8interactor50.30018.216BUD22 (PF09073, IPR015158): BUD22
Cse1 (PF08506, IPR013713): Cse1
HAND (PF09110, IPR015194): HAND
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
46 IRS1interactor110.6556.803CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
47 ITSN1interactor60.9000.250C2 (PF00168, IPR000008, SM00239): C2 domain
VIT1 (PF01988, IPR008217): VIT family
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon
GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
48 KIToncoprotein100.8003.236ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
49 KYNUinteractor130.51338.236Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
CaKB (PF03185, IPR003930): Calcium-activated potassium channel, beta subunit
50 LCKoncoprotein110.5786.293Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
51 LDHAinteractor140.46278.932Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
52 LDHAL6Binteractor70.7621.750Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
53 LDHBinteractor90.57133.507Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
54 MOV10interactor110.255155.018AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
55 MS4A2interactor31.0000CD20 (PF04103, IPR007237): CD20-like family
56 MVDinteractor190.45849.575GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
57 MYD88oncoprotein70.60010.347Death (PF00531, IPR000488, SM00005): Death domain
TIR (PF01582, IPR000157, SM00255): TIR domain
58 NAMPTinteractor80.500107.457NAPRTase (PF04095, IPR007229): Nicotinate phosphoribosyltransferase (NAPRTase) family
59 NCK2interactor110.4898.923SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
60 NDRG1suppressor100.51114.479Ndr (PF03096, IPR004142): Ndr family
61 NEDD4suppressor140.37259.981Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
62 NHLRC2interactor40.66711.274NHL (PF01436, IPR001258): NHL repeat
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
Thioredoxin_8 (PF13905, IPR012336): Thioredoxin-like
63 NTRK1oncoprotein380.1742177.109I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
64 NXF1interactor140.167266.722NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
65 PDGFRBoncoprotein140.56420.861I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
TonB_N (PF16031): TonB N-terminal region
66 PIK3R1oncoprotein250.500113.275RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
67 PIK3R2oncoprotein180.55669.883RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
68 PLCG2interactor100.6447.106C2 (PF00168, IPR000008, SM00239): C2 domain
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
69 PSMG4interactor100PAC4 (PF16093, IPR032157): Proteasome assembly chaperone 4
70 PTK2Binteractor120.61820.909FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
71 PTPN11suppressor170.558104.315SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
72 RNF11protein found in more fusions60.7005.840zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
73 RPIAinteractor60.20086.005Rib_5-P_isom_A (PF06026, IPR004788): Ribose 5-phosphate isomerase A (phosphoriboisomerase A)
Sugar-bind (PF04198, IPR007324): Putative sugar-binding domain
74 RPS6KA1oncoprotein130.603104.546Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
75 SH3KBP1protein found in more fusions210.379155.508Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
76 SHC1oncoprotein180.52979.426PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
77 SIRT2suppressor21.0000SIR2 (PF02146, IPR003000): Sir2 family
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
78 SOD2suppressor31.0000Sod_Fe_C (PF02777, IPR019832): Iron/manganese superoxide dismutases, C-terminal domain
Sod_Fe_N (PF00081, IPR019831): Iron/manganese superoxide dismutases, alpha-hairpin domain
79 SORBS3interactor40.6670.222Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
80 SP7interactor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
81 SPP1oncoprotein100Osteopontin (PF00865, IPR002038, SM00017): Osteopontin
82 SPRY1interactor50.7000.650PAP1 (PF08601, IPR013910): Transcription factor PAP1
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
83 SYKsuppressor240.312274.032Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
84 TANGO2interactor21.0000TANGO2 (PF05742, IPR008551): Transport and Golgi organisation 2
85 TANKsuppressor50.8330.333DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
TBD (PF12845, IPR024581): TBD domain
86 TERF1interactor90.286199.266TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
87 TGFB1I1interactor21.0000LIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
88 TICAM1protein found in more fusions70.6674.710Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
TIR_2 (PF13676, IPR000157): TIR domain
89 TRAF3oncoprotein80.47639.800ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
90 TRAF6protein found in more fusions130.303149.382SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
91 UBASH3Binteractor110.7567.366His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily
SH3_9 (PF14604, IPR001452): Variant SH3 domain
92 UBCprotein found in more fusions240.328338.063ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
93 UBE2D2oncoprotein80.6193.486UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
94 USP12suppressor40.8330.350UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
95 USP7oncoprotein120.200370.091MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
96 VAV1oncoprotein150.53333.928PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
97 VAV2oncoprotein80.7505.576PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
CotJB (PF12652, IPR024207): CotJB protein
98 WASoncoprotein110.56413.026CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
PRIMA1 (PF16101): Proline-rich membrane anchor 1
99 ZAP70interactor130.65216.057Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain

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