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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ARID4B, TM9SF2 (from a repository: Wed Apr 12 10:59:30 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)36
The number (and %) of the onco-proteins11 (30.56 %)
The number (and %) of the tumor suppressors7 (19.44 %)
Total number of binary PPIs (saturation %)140 (22.22 %)
The number (and %) of affected PPIs34 (24.29 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI7.167
Assortativity coefficient-0.0806
The network average Clustering coefficient0.574
The number (and %) of a zero Clustering coefficients8 (22.22 %)
The number (and %) of a zero Betweenness Centrality13 (36.11 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ARID4B,TM9SF2 All fusions
Proteins found in more fusions KIF11 (see 1 fusions); SMAD4 (see 2 fusions); DDB1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ARID4Bparental protein260.268527.817ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
CDC45 (PF02724, IPR003874): CDC45-like protein
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
E7 (PF00527, IPR000148): E7 protein, Early protein
NOA36 (PF06524, IPR010531): NOA36 protein
PWWP (PF00855, IPR000313, SM00293): PWWP domain
RBB1NT (PF08169, IPR012603): RBB1NT (NUC162) domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
2 TM9SF2parental protein80.107202.013FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
EMP70 (PF02990, IPR004240): Endomembrane protein 70
3 ARID4Aoncoprotein100.73311.238ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
PWWP (PF00855, IPR000313, SM00293): PWWP domain
RBB1NT (PF08169, IPR012603): RBB1NT (NUC162) domain
UPF0239 (PF06783, IPR009621): Uncharacterised protein family (UPF0239)
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
DUF3464 (PF11947, IPR021855): Protein of unknown function (DUF3464)
DUF3899 (PF13038, IPR025007): Domain of unknown function (DUF3899)
FAM163 (PF15069, IPR029379): FAM163 family
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
TFB6 (PF17110, IPR031349): Subunit 11 of the general transcription factor TFIIH
4 ATP1B3interactor100Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
5 CASP1oncoprotein31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
6 CTSKinteractor100Inhibitor_I29 (PF08246, IPR013201, SM00848): Cathepsin propeptide inhibitor domain (I29)
Peptidase_C1 (PF00112, IPR000668, SM00645): Papain family cysteine protease
7 CUL4Boncoprotein110.74572.315Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
8 DDB1protein found in more fusions110.8896.127CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
9 ETS1oncoprotein100Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
10 FBXW7suppressor31.0000Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
11 FOXK1interactor120.83313.677Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
12 FOXK2interactor110.9450.667FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
13 HDAC1suppressor160.705131.113FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
14 HDAC2suppressor160.69534.174Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
15 HIST1H2BGoncoprotein21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
16 ING2suppressor120.8188.338PHD (PF00628, IPR019787, SM00249): PHD-finger
S1FA (PF04689, IPR006779): DNA binding protein S1FA
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
17 KIF11protein found in more fusions40.6677.767Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
18 LACC1interactor31.0000Cu-oxidase_4 (PF02578, IPR003730): Multi-copper polyphenol oxidoreductase laccase
19 LOC101929876interactor100NA
20 MMGT1interactor21.0000MMgT (PF10270, IPR018937): Membrane magnesium transporter
21 MXD1oncoprotein80.8930.667HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
22 NTRK1oncoprotein110.333262.171I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
23 RANBP2oncoprotein200Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693)
IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain
Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
24 RBBP7suppressor130.8593.494WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
25 RPN2interactor30.33386.199Ribophorin_II (PF05817, IPR008814): Oligosaccharyltransferase subunit Ribophorin II
26 RPS26interactor100Ribosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e
27 SAP130interactor130.8463.549SAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus
28 SAP30interactor140.8135.266Titin_Z (PF09042, IPR015129): Titin Z
zf-SAP30 (PF13866, IPR025717): SAP30 zinc-finger
SAP30_Sin3_bdg (PF13867, IPR025718): Sin3 binding region of histone deacetylase complex subunit SAP30
29 SIN3Aoncoprotein170.60362.157Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
30 SIRT1suppressor41.0000DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
31 SLC25A3interactor2026.974Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
32 SMAD4suppressor3085.085MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
33 SRSF7interactor30.33372.979RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
zf-CCHC (PF00098, IPR001878): Zinc knuckle
34 SUDS3interactor150.74713.187Sds3 (PF08598, IPR013907): Sds3-like
35 TCTN3interactor40.50015.025DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
36 UNC93B1interactor21.0000UNC-93 (PF05978, IPR010291): Ion channel regulatory protein UNC-93
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)

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