Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CNTNAP1, PDPK1 (from a repository: Tue Feb 6 16:55:18 2018)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)60
The number (and %) of the onco-proteins13 (21.67 %)
The number (and %) of the tumor suppressors9 (15.00 %)
Total number of binary PPIs (saturation %)166 (9.38 %)
The number (and %) of affected PPIs59 (35.54 %)
The number of possible different fusions14
PPI diameter4
PPI radius3
The average degree of PPI4.667
Assortativity coefficient-0.2426
The network average Clustering coefficient0.531
The number (and %) of a zero Clustering coefficients11 (18.33 %)
The number (and %) of a zero Betweenness Centrality26 (43.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CNTNAP1,PDPK1 All fusions
Proteins found in more fusions PRKCD (see 2 fusions); MAP3K7 (see 7 fusions); ILK (see 1 fusions); APP (see 4 fusions); G3BP1 (see 1 fusions); SGK1 (see 2 fusions); LUC7L2 (see 2 fusions); SMARCB1 (see 12 fusions); STRAP (see 2 fusions); ZDHHC17 (see 2 fusions); KATNBL1 (see 1 fusions); YWHAH (see 2 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CNTNAP1parental protein50.30066.936EGF (PF00008, IPR000742, SM00181): EGF-like domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
2 PDPK1parental protein540.0522702.581Pkinase (PF00069, IPR000719): Protein kinase domain
PH_3 (PF14593): PH domain
3 AKT1oncoprotein120.21847.924PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4 APBB3interactor21.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
WW (PF00397, IPR001202, SM00456): WW domain
5 APPprotein found in more fusions190.144221.166APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 BLMHinteractor50.8330.667Peptidase_C1_2 (PF03051, IPR004134): Peptidase C1-like family
7 CARD11oncoprotein50.6671.500CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
8 CPA4interactor100Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
Propep_M14 (PF02244, IPR003146): Carboxypeptidase activation peptide
9 CSKinteractor30.6670.500Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
10 DDIT4interactor100RTP801_C (PF07809, IPR012918): RTP801 C-terminal region
11 FAM199Xinteractor21.0000FAM199X (PF15814, IPR029672): Protein family FAM199X
12 FAM213Binteractor100AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
AhpC-TSA_2 (PF13911, IPR032801): AhpC/TSA antioxidant enzyme
13 FBXO6interactor4063.238FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
14 G3BP1protein found in more fusions70.4677.643NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
15 GIT1interactor200ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
FlxA (PF14282, IPR025577): FlxA-like protein
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
16 ILKsuppressor80.19099.717Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
17 KATNBL1protein found in more fusions200Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
Katanin_con80 (PF13925, IPR028021): con80 domain of Katanin
18 KCNA1interactor31.0000Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
19 KCNA2interactor41.0000Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
20 LUC7L2protein found in more fusions60.5007.102LUC7 (PF03194, IPR004882): LUC7 N_terminus
Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein
Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
21 MAP3K7oncoprotein70.4007.667Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
22 MAPK8oncoprotein70.4677.700DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
23 PA2G4interactor50.4005.500Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
TraC (PF07820, IPR012930): TraC-like protein
24 PEA15suppressor30.6671.000DED (PF01335, IPR001875, SM00031): Death effector domain
25 PHAXinteractor21.0000RNA_GG_bind (PF10258, IPR019385): PHAX RNA-binding domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
26 PKN1interactor40.6671.000C2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
27 PKN2interactor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
28 PNO1interactor21.0000KH_1 (PF00013, IPR004088, SM00322): KH domain
29 POLDIP2interactor21.0000DUF525 (PF04379, IPR007474): Protein of unknown function (DUF525)
YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
30 PRKACAinteractor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
31 PRKCBsuppressor50.5001.833C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
32 PRKCDsuppressor50.5002.667Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
33 PRKCIinteractor50.6003.567PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
34 PRKCQinteractor70.4008.475Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
35 PRKCZinteractor60.6003.286PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
36 PRSS23interactor21.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
37 RPS6KA3interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
38 RTN4suppressor60.300183.091CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
39 SBF1interactor100dDENN (PF03455, IPR005112, SM00801): dDENN domain
DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain
GRAM (PF02893, IPR004182, SM00568): GRAM domain
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
PH (PF00169, IPR001849, SM00233): PH domain
uDENN (PF03456, IPR005113, SM00800): uDENN domain
T2SSJ (PF11612, IPR010055): Type II secretion system (T2SS), protein J
SBF2 (PF12335, IPR022096): Myotubularin protein
40 SERPINA4interactor21.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
41 SGK1oncoprotein50.5006.586Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
42 SLC9A3R2interactor30.333139.917EBP50_C (PF09007, IPR015098): EBP50, C-terminal
GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
43 SMARCB1suppressor60.5004.889SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
44 SND1interactor31.0000TUDOR (PF00567, IPR002999, SM00333): Tudor domain
SNase (PF00565, IPR016071, SM00318): Staphylococcal nuclease homologue
45 SOCS3suppressor40.5003.421SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
46 SPINT2suppressor4091.309Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
47 SRPK1interactor31.0000FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
48 STRAPprotein found in more fusions40.33334.094WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
49 TBL2suppressor30154.067eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
FdsD (PF11390, IPR021074): NADH-dependant formate dehydrogenase delta subunit FdsD
50 TCAPinteractor100Telethonin (PF09470, IPR015667): Telethonin protein
51 WDCPinteractor30.6670.667DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
52 WDR5interactor50.4006.944WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
53 XPO1interactor130.16776.158CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
54 XPO7interactor21.0000IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
55 XRCC6oncoprotein200Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain
56 YWHAHprotein found in more fusions60.7002.61914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
57 YWHAQinteractor80.25072.57014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
58 ZC3HC1interactor21.0000Rsm1 (PF08600, IPR013909): Rsm1-like
zf-C3HC (PF07967, IPR012935): C3HC zinc finger-like
59 ZDHHC17protein found in more fusions31.0000zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
60 ZNF133interactor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

B a c k    t o    T o p ⇑