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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)150
The number (and %) of the onco-proteins43 (28.67 %)
The number (and %) of the tumor suppressors23 (15.33 %)
Total number of binary PPIs (saturation %)969 (8.67 %)
The number (and %) of affected PPIs152 (15.69 %)
The number of possible different fusions26
PPI diameter4
PPI radius2
The average degree of PPI12.213
Assortativity coefficient-0.2180
The network average Clustering coefficient0.505
The number (and %) of a zero Clustering coefficients9 (6.00 %)
The number (and %) of a zero Betweenness Centrality24 (16.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: UFM1,RFWD2 All fusions
Proteins found in more fusions PTPN11 (see 1 fusions); CUL4A (see 4 fusions); TKT (see 5 fusions); FOXO1 (see 3 fusions); SFN (see 1 fusions); DCAF1 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); MRPL12 (see 1 fusions); RANGAP1 (see 2 fusions); MDM4 (see 2 fusions); MVP (see 2 fusions); UBE2D2 (see 1 fusions); AHCYL1 (see 2 fusions); MDH2 (see 1 fusions); YWHAZ (see 5 fusions); CSRP1 (see 4 fusions); BCAT2 (see 1 fusions); G6PD (see 4 fusions); UBE2E3 (see 5 fusions); FOS (see 4 fusions); COPS5 (see 1 fusions); UBE2E1 (see 1 fusions); DDB1 (see 4 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 UFM1parental protein760.0786352.060Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
2 RFWD2parental protein760.1505143.522Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
IncA (PF04156, IPR007285): IncA protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
WD40_like (PF17005, IPR031544): WD40-like domain
3 ACTR2interactor200.337423.009Actin (PF00022, IPR004000, SM00268): Actin
4 AHCYL1suppressor240.336256.815AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
5 ARHGDIAinteractor4014.066Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
6 ARHGDIBinteractor100Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
7 ATF6interactor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
8 BCAT2protein found in more fusions200Aminotran_4 (PF01063, IPR001544): Amino-transferase class IV
9 BLVRBinteractor100NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
10 BTBD2interactor100.73321.668BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PHR (PF08005, IPR012983): PHR domain
11 CAPGsuppressor70.57165.953Gelsolin (PF00626, IPR007123): Gelsolin repeat
12 CCT2interactor160.62595.990Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
13 CCT3interactor130.80846.527Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
14 CCT4interactor170.566136.844Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
15 CCT5interactor160.567132.744Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
16 CCT6Ainteractor120.90911.020Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
17 CCT7interactor120.90911.020Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
18 CCT8interactor150.686125.642Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
19 CDK5RAP3interactor40.33322.226DUF773 (PF05600, IPR008491): Protein of unknown function (DUF773)
20 CDKN1Bsuppressor160.400115.019CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
21 CFL1interactor130.28269.345Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
22 COPS2suppressor220.68834.509YozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
23 COPS3interactor250.66035.844RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
24 COPS4interactor270.59882.779DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
25 COPS5protein found in more fusions470.301946.567JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
26 COPS6interactor320.482233.685DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
27 COPS7Ainteractor220.76617.949PCI (PF01399, IPR000717, SM00088): PCI domain
28 COPS7Binteractor200.75828.494PCI (PF01399, IPR000717, SM00088): PCI domain
29 COPS8interactor200.8428.765CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
30 CRIP1interactor80.46412.371LIM (PF00412, IPR001781, SM00132): LIM domain
31 CRTC2oncoprotein30.6670.873TORC_N (PF12884, IPR024783): Transducer of regulated CREB activity, N terminus
TORC_M (PF12885, IPR024784): Transducer of regulated CREB activity middle domain
TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus
32 CSRP1protein found in more fusions31.0000LIM (PF00412, IPR001781, SM00132): LIM domain
zf-MYND (PF01753, IPR002893): MYND finger
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
33 CUL1suppressor340.318464.754Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
34 CUL2suppressor240.420308.041Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
35 CUL3protein found in more fusions510.2191617.451Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
36 CUL4Aprotein found in more fusions320.488205.764Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
37 CUL4Boncoprotein280.534200.678Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
38 DCAF1protein found in more fusions180.75023.840DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
LisH (PF08513, IPR013720, SM00667): LisH
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
39 DCAF11interactor111.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
40 DDA1interactor220.597184.904DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
41 DDB1protein found in more fusions270.594117.230CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
42 DDB2suppressor260.480147.660WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
43 DET1interactor140.35298.121Det1 (PF09737, IPR019138): De-etiolated protein 1 Det1
44 DIABLOsuppressor31.0000Smac_DIABLO (PF09057, IPR015142): Second Mitochondria-derived Activator of Caspases
45 DMC1interactor200Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
46 EFL1interactor90.66713.169EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
47 ELAVL1oncoprotein340.1691524.152RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
48 ERCC8oncoprotein170.78720.711WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4859 (PF16151, IPR032339): Domain of unknown function (DUF4859)
49 ESDinteractor50.50021.689Esterase (PF00756, IPR000801): Putative esterase
50 ETS1oncoprotein70.38137.226Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
51 ETS2suppressor60.6005.585Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
52 ETV1oncoprotein50.4007.411Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
53 ETV4oncoprotein21.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
54 ETV5oncoprotein50.40020.534Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
55 FOSoncoprotein130.197226.650bZIP_1 (PF00170, IPR004827): bZIP transcription factor
56 FOSL2oncoprotein70.38111.344bZIP_1 (PF00170, IPR004827): bZIP transcription factor
57 FOXO1suppressor50.5003.313K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
58 G6PDprotein found in more fusions90.25089.833G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain
G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
59 GOT1interactor60.4679.608Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
60 GRHPRinteractor40.33352.8072-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
61 GSK3Bsuppressor110.267253.256Pkinase (PF00069, IPR000719): Protein kinase domain
62 HIBCHinteractor30.6671.710ECH_2 (PF16113, IPR032259): Enoyl-CoA hydratase/isomerase
63 HMGCS1interactor21.0000HMG_CoA_synt_C (PF08540, IPR013746): Hydroxymethylglutaryl-coenzyme A synthase C terminal
HMG_CoA_synt_N (PF01154, IPR013528): Hydroxymethylglutaryl-coenzyme A synthase N terminal
64 HSPA2interactor31.0000HSP70 (PF00012, IPR013126): Hsp70 protein
65 HSPA6interactor50.9000.208HSP70 (PF00012, IPR013126): Hsp70 protein
66 HSPA8oncoprotein180.399289.026HSP70 (PF00012, IPR013126): Hsp70 protein
67 HSPE1interactor170.206237.762Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
68 JUNoncoprotein160.219259.190bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
69 JUNBoncoprotein30.6670.800bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
70 JUNDoncoprotein70.57120.613bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
71 KIF1BPinteractor71.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
KBP_C (PF12309, IPR022083): KIF-1 binding protein C terminal
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
72 KLHL42interactor70.7624.824BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
Kelch_6 (PF13964): Kelch motif
73 LPPoncoprotein70.38140.644LIM (PF00412, IPR001781, SM00132): LIM domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
74 LRR1interactor130.9101.508LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
75 MDH2protein found in more fusions60.50021.337Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
76 MDM2oncoprotein280.228402.394Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
77 MDM4oncoprotein110.51125.712zf-FLZ (PF04570, IPR007650): zinc-finger of the FCS-type, C2-C2
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
78 MIFoncoprotein90.393118.468MIF (PF01187, IPR001398): Macrophage migration inhibitory factor (MIF)
79 MRPL12protein found in more fusions40.33311.793Ribosomal_L12 (PF00542, IPR013823): Ribosomal protein L7/L12 C-terminal domain
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
80 MSI2oncoprotein40.33322.450NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
81 MTAPsuppressor60.33340.307PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
82 MVPoncoprotein60.30044.216Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
83 NDRG1suppressor40.5008.513Ndr (PF03096, IPR004142): Ndr family
84 NPLOC4interactor70.5245.931NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
85 OSGEPinteractor110.53383.220Peptidase_M22 (PF00814, IPR000905): Glycoprotease family
86 PAICSinteractor90.39318.960AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
87 PANK4interactor71.0000DUF89 (PF01937, IPR002791): Protein of unknown function DUF89
Fumble (PF03630, IPR004567): Fumble
88 PARP4interactor21.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
VIT (PF08487, IPR013694, SM00609): Vault protein inter-alpha-trypsin domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
89 PKMoncoprotein150.219240.897PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
90 PPA2interactor21.0000Pyrophosphatase (PF00719, IPR008162): Inorganic pyrophosphatase
91 PSAT1interactor31.0000Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
92 PSMB1interactor60.20042.151Proteasome (PF00227, IPR001353): Proteasome subunit
93 PSMC6interactor70.20037.517AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
94 PTPN1suppressor30.3333.348Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
95 PTPN11suppressor40.6672.166SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
96 RAD23Bsuppressor100.28974.473K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
97 RANGAP1protein found in more fusions110.53392.289RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain
SDA1 (PF05285, IPR007949): SDA1
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
98 RB1CC1suppressor21.0000Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
99 RBBP6oncoprotein50.30045.055DUF936 (PF06075, IPR010341): Plant protein of unknown function (DUF936)
DWNN (PF08783, IPR014891): DWNN domain
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
U-box (PF04564, IPR003613, SM00504): U-box domain
SBF2 (PF12335, IPR022096): Myotubularin protein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
zf-CCHC_2 (PF13696, IPR025829): Zinc knuckle
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
PRIMA1 (PF16101): Proline-rich membrane anchor 1
100 RBX1oncoprotein310.457211.266zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
101 RCHY1suppressor100.472117.639C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
102 RCN1interactor30.3335.598EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
103 REG1Ainteractor100Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
104 RFKinteractor30.6671.210Flavokinase (PF01687, IPR015865, SM00904): Riboflavin kinase
105 RPS6KA6suppressor100Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
106 SFNsuppressor90.46453.89314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
107 SIPA1oncoprotein100IncA (PF04156, IPR007285): IncA protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
108 SKP1oncoprotein150.61060.931Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
109 SOD1interactor170.300157.211Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
110 SPRinteractor80.5718.586adh_short (PF00106, IPR002198): short chain dehydrogenase
111 STK40interactor100.26739.078Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
112 TAGLN3interactor50.5004.344Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
113 TCEB2interactor110.72756.876ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
114 TCP1interactor140.75839.785Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
115 TIAL1interactor110.400203.609RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
116 TKTprotein found in more fusions160.352106.684Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
117 TP53suppressor430.1721220.846DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
118 TP53RKoncoprotein90.667113.401APH (PF01636, IPR002575): Phosphotransferase enzyme family
Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
119 TRAP1oncoprotein50.60011.945HSP90 (PF00183, IPR001404): Hsp90 protein
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
120 TRIB1interactor50.60020.529Pkinase (PF00069, IPR000719): Protein kinase domain
121 TRIB2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
122 TRIB3interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
123 TRIP6interactor80.321123.224DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain
124 TTC1interactor110.309100.429TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
125 TTLL12interactor100.53317.987TTL (PF03133, IPR004344): Tubulin-tyrosine ligase family
126 UBA5interactor50.33321.493Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
ThiF (PF00899, IPR000594): ThiF family
127 UBA52interactor70.57110.051Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
128 UBE2D1interactor230.325505.749UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
129 UBE2D2oncoprotein200.333378.344UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
130 UBE2D3interactor80.38145.913UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
131 UBE2D4interactor3013.759UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
132 UBE2E1protein found in more fusions50.16748.871UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
133 UBE2E3protein found in more fusions130.364219.987UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
134 UBE2L3interactor200.345203.889UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
135 UBE2V2interactor100.6677.218UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
136 UBE2Winteractor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
137 UBE4Bsuppressor180.434112.789DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Ufd2P_core (PF10408, IPR019474): Ubiquitin elongating factor core
U-box (PF04564, IPR003613, SM00504): U-box domain
DUF4568 (PF15132, IPR027919): Domain of unknown function (DUF4568)
138 UBXN1interactor200.357260.594Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
139 UBXN7interactor280.294589.562UBX (PF00789, IPR001012, SM00166): UBX domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
140 UFC1interactor160.37577.280UFC1 (PF08694, IPR014806): Ubiquitin-fold modifier-conjugating enzyme 1
141 USP34interactor120.7586.700Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUF3517 (PF12030, IPR021905): Domain of unknown function (DUF3517)
142 USP9Xinteractor190.450169.895DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
143 VDAC1interactor30.6672.386Porin_3 (PF01459, IPR027246): Eukaryotic porin
144 WDR5interactor70.8570.710WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
145 YAP1suppressor110.52756.565Bindin (PF02084, IPR000775): Bindin
WW (PF00397, IPR001202, SM00456): WW domain
GspL_C (PF12693, IPR025691): GspL periplasmic domain
FAM181 (PF15238, IPR029359): FAM181
146 YWHABinteractor90.38967.78014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
147 YWHAZprotein found in more fusions160.333142.30714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
148 ZFYVE19interactor160.450129.101Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Rpr2 (PF04032, IPR007175): RNAse P Rpr2/Rpp21/SNM1 subunit domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
149 ZNF397interactor21.0000SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
150 ZPR1interactor150.40051.465zf-ZPR1 (PF03367, IPR004457, SM00709): ZPR1 zinc-finger domain

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