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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RAB14, ZHX2 (from a repository: Thu Feb 8 00:24:20 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)55
The number (and %) of the onco-proteins18 (32.73 %)
The number (and %) of the tumor suppressors4 (7.27 %)
Total number of binary PPIs (saturation %)157 (10.57 %)
The number (and %) of affected PPIs54 (34.39 %)
The number of possible different fusions11
PPI diameter4
PPI radius2
The average degree of PPI4.909
Assortativity coefficient-0.2288
The network average Clustering coefficient0.464
The number (and %) of a zero Clustering coefficients15 (27.27 %)
The number (and %) of a zero Betweenness Centrality21 (38.18 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ZHX2,RAB14 All fusions
Proteins found in more fusions OPTN (see 1 fusions); CUL7 (see 2 fusions); APP (see 4 fusions); EXOC5 (see 1 fusions); ATXN1 (see 3 fusions); RAB11FIP1 (see 2 fusions); ATP6V1C1 (see 3 fusions); VCP (see 4 fusions); RPA1 (see 1 fusions); YWHAZ (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ZHX2parental protein110.091387.248zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
DUF4343 (PF14243, IPR025643): Domain of unknown function (DUF4343)
2 RAB14parental protein430.0682074.548Ras (PF00071, IPR001806, SM00173): Ras family
3 ABCC2interactor21.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
DUF805 (PF05656, IPR008523): Protein of unknown function (DUF805)
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
4 ACTL6Ainteractor100Actin (PF00022, IPR004000, SM00268): Actin
5 APPprotein found in more fusions110.200277.013APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ATF2oncoprotein31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
7 ATL3interactor30.6674.952GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
8 ATP6AP2interactor40.6672.452Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
9 ATP6V1C1protein found in more fusions40.6671.000V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
10 ATXN1protein found in more fusions70.200139.173AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
11 CCDC8interactor90.71418.038Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
12 CDC42oncoprotein50.6672.400Ras (PF00071, IPR001806, SM00173): Ras family
13 CUL7protein found in more fusions110.53345.084ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
14 DGUOKinteractor31.0000dNK (PF01712, IPR002624): Deoxynucleoside kinase
15 DHRS2interactor2013.167adh_short (PF00106, IPR002198): short chain dehydrogenase
16 DSTYKinteractor100APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
17 EEDsuppressor50.8330.222WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
18 EXOC5protein found in more fusions31.0000Sec10 (PF07393, IPR009976): Exocyst complex component Sec10
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
19 GDI1interactor40.6672.000GDI (PF00996, IPR018203): GDP dissociation inhibitor
20 HAX1interactor40.6672.000Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
21 HNRNPFinteractor110.45539.085RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
22 HRASoncoprotein206.638Ras (PF00071, IPR001806, SM00173): Ras family
23 HSPA5oncoprotein140.48729.818HSP70 (PF00012, IPR013126): Hsp70 protein
24 IFI16suppressor30.6672.500HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
25 ILF3oncoprotein90.5836.867dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
26 ILVBLinteractor40.33349.733TPP_enzyme_C (PF02775, IPR011766): Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
TPP_enzyme_N (PF02776, IPR012001): Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
27 IQCB1interactor50.6003.952DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
28 LAMTOR3interactor100MAPKK1_Int (PF08923, IPR015019): Mitogen-activated protein kinase kinase 1 interacting
29 LATinteractor100LAT (PF15234, IPR008359): Linker for activation of T-cells
30 NAGPAinteractor100EGF_2 (PF07974, IPR013111): EGF-like domain
NAGPA (PF09992, IPR018711): Phosphodiester glycosidase
31 NUFIP1interactor100NUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
32 OCRLinteractor100Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
OCRL_clath_bd (PF16726, IPR031995): Inositol polyphosphate 5-phosphatase clathrin binding domain
33 OPTNprotein found in more fusions40.33318.479ARD (PF03079, IPR004313): ARD/ARD' family
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
34 RAB11FIP1protein found in more fusions200C2 (PF00168, IPR000008, SM00239): C2 domain
RBD-FIP (PF09457, IPR019018): FIP domain
SOUL (PF04832, IPR006917): SOUL heme-binding protein
Latarcin (PF10279, IPR018802): Latarcin precursor
35 RAB11FIP5interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
RBD-FIP (PF09457, IPR019018): FIP domain
36 RAB4Boncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
37 RBSNinteractor100DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Histone_HNS (PF00816, IPR001801): H-NS histone family
zf-AD (PF07776, IPR012934, SM00868): Zinc-finger associated domain (zf-AD)
Rbsn (PF11464, IPR021565): Rabenosyn Rab binding domain
DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
38 RPA1suppressor100.6946.506Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
39 RPA2oncoprotein70.7147.384RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
40 RPA3interactor80.7146.766Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
41 RRASoncoprotein206.638Ras (PF00071, IPR001806, SM00173): Ras family
42 RUFY1interactor31.0000DM (PF00751, IPR001275, SM00301): DM DNA binding domain
FAA_hydrolase_N (PF09298, IPR015377): Fumarylacetoacetase N-terminal
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
RUN (PF02759, IPR004012, SM00593): RUN domain
Tektin (PF03148, IPR000435): Tektin family
43 SDHAsuppressor21.0000FAD_binding_2 (PF00890, IPR003953): FAD binding domain
Succ_DH_flav_C (PF02910, IPR015939): Fumarate reductase flavoprotein C-term
44 SLC25A41interactor30137.667Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
45 SLC33A1interactor21.0000Acatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
46 TACC3oncoprotein2068.000TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
47 TGOLN2interactor21.0000MSA_2 (PF00985, IPR001136): Merozoite Surface Antigen 2 (MSA-2) family
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
SbcCD_C (PF13558): Putative exonuclease SbcCD, C subunit
TUTF7_u4 (PF16631): Unstructured region 4 on terminal uridylyltransferase 7
48 UBL4Ainteractor70.42911.349ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
49 UNKinteractor70.23898.344MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
50 UQCRFS1interactor40.5005.600Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
51 VCPprotein found in more fusions100.38999.890AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
52 YWHAQinteractor70.42960.41014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
53 YWHAZprotein found in more fusions80.33343.07414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
54 ZHX1interactor41.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez
zf-C2H2_4 (PF13894): C2H2-type zinc finger
TerB_C (PF15615, IPR028932): TerB-C domain
55 ZHX3interactor41.0000NUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
TerB_C (PF15615, IPR028932): TerB-C domain

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