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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PHF21A, GOLIM4 (from a repository: Wed Feb 14 10:38:28 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)56
The number (and %) of the onco-proteins11 (19.64 %)
The number (and %) of the tumor suppressors8 (14.29 %)
Total number of binary PPIs (saturation %)156 (10.13 %)
The number (and %) of affected PPIs55 (35.26 %)
The number of possible different fusions5
PPI diameter4
PPI radius2
The average degree of PPI4.857
Assortativity coefficient-0.3303
The network average Clustering coefficient0.448
The number (and %) of a zero Clustering coefficients16 (28.57 %)
The number (and %) of a zero Betweenness Centrality19 (33.93 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GOLIM4,PHF21A All fusions
Proteins found in more fusions KDM1A (see 2 fusions); DDX5 (see 1 fusions); RCOR1 (see 2 fusions); HMG20A (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GOLIM4parental protein260.0831114.862Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
DUF3410 (PF11890, IPR024531): Domain of unknown function (DUF3410)
DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584)
DUF4525 (PF15027, IPR027833): Domain of unknown function (DUF4525)
2 PHF21Aparental protein290.1031340.916AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DDHD (PF02862, IPR004177, SM01127): DDHD domain
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Peroxidase_2 (PF01328, IPR000028): Peroxidase, family 2
PHD (PF00628, IPR019787, SM00249): PHD-finger
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region
3 AP4E1interactor30.6672.400Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Coatamer_beta_C (PF07718, IPR011710): Coatomer beta C-terminal region
AP4E_app_platf (PF14807, IPR028269): Adaptin AP4 complex epsilon appendage platform
4 AP4S1interactor30.33314.138Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
5 ATP6AP2interactor200Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
6 B3GAT3interactor31.0000Glyco_transf_43 (PF03360, IPR005027): Glycosyltransferase family 43
7 BANPsuppressor31.0000DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
8 CD14interactor100LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
9 CDC42oncoprotein70.46720.640Ras (PF00071, IPR001806, SM00173): Ras family
10 DDX5oncoprotein60.50071.686DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
P68HR (PF08061, IPR012587): P68HR (NUC004) repeat
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
11 ELAVL1oncoprotein140.218680.867RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12 EPHA2suppressor41.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
13 ESCO2interactor51.0000Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
zf-C2H2_3 (PF13878, IPR028005): zinc-finger of acetyl-transferase ESCO
Acetyltransf_13 (PF13880, IPR028009): ESCO1/2 acetyl-transferase
14 FGFR1OPoncoprotein3024.998FOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domain
15 FHL3interactor31.0000LIM (PF00412, IPR001781, SM00132): LIM domain
Med27 (PF11571, IPR021627): Mediator complex subunit 27
16 FUSsuppressor40.50039.333Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
17 GOLT1Binteractor50.8004.642Got1 (PF04178, IPR007305): Got1/Sft2-like family
18 GTF2Iinteractor60.53369.504GTF2I (PF02946, IPR004212): GTF2I-like repeat
19 HAUS7interactor21.0000M3 (PF09213, IPR015296): M3
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
20 HDAC1suppressor120.49165.726FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
21 HDAC2suppressor140.462145.952Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
22 HIST2H3Cinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
23 HIST3H3interactor50.7003.238Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
24 HLA-DPA1interactor100MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
25 HMG20Aprotein found in more fusions80.81016.941DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
MlaC (PF05494, IPR008869): MlaC protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
26 HMG20Binteractor80.67910.467IncA (PF04156, IPR007285): IncA protein
NEMP (PF10225, IPR019358): NEMP family
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
27 IP6K3interactor100IPK (PF03770, IPR005522): Inositol polyphosphate kinase
28 IQGAP1interactor30.6671.036CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
29 KDM1Aprotein found in more fusions130.455105.570Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
30 KIF22interactor2030.386Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
HHH_3 (PF12836): Helix-hairpin-helix motif
31 KRASoncoprotein40.6675.765Ras (PF00071, IPR001806, SM00173): Ras family
32 KRT40interactor2023.067Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
33 LLGL2interactor3042.733Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal
LLGL (PF08366, IPR013577): LLGL2
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
34 LPXNinteractor100LIM (PF00412, IPR001781, SM00132): LIM domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
35 MMGT1interactor40.8334.142MMgT (PF10270, IPR018937): Membrane magnesium transporter
36 MYH13interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
37 NAF1interactor100AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
Gar1 (PF04410, IPR007504): Gar1/Naf1 RNA binding region
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
38 NTRK1oncoprotein130.227250.502I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
39 NUP58interactor40.5007.000Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
40 NUP62interactor31.0000Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
41 PARD6Binteractor30.33337.067PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
42 POMKinteractor100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
43 PTPN1suppressor40.5006.310Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
44 RBPJinteractor50.8007.293BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain
LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding
TIG (PF01833, IPR002909): IPT/TIG domain
45 RCOR1protein found in more fusions100.66713.202DivIC (PF04977, IPR007060): Septum formation initiator
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
FAM76 (PF16046, IPR032017): FAM76 protein
46 SCLT1oncoprotein60.267107.804DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
XhlA (PF10779, IPR019715): Haemolysin XhlA
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Imm7 (PF15585, IPR028965): Immunity protein 7
CCCAP (PF15964, IPR031887): Centrosomal colon cancer autoantigen protein family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
47 SLC39A4suppressor30.6670.667Zip (PF02535, IPR003689): ZIP Zinc transporter
Class_IIIsignal (PF04021, IPR007166): Class III signal peptide
48 SOD1interactor3023.067Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
49 SPACA1interactor100DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
50 SYNE4interactor100KASH (PF10541, IPR012315): Nuclear envelope localisation domain
51 TAF10interactor30.6677.417TFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunit
52 TRAF1oncoprotein40.6671.000HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
53 TXN2interactor3073.133Thioredoxin (PF00085, IPR013766): Thioredoxin
54 VAPAinteractor60.46711.132DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
55 VPS50interactor30.33329.398Vps54_N (PF10475, IPR019515): Vacuolar-sorting protein 54, of GARP complex
DUF2451 (PF10474, IPR019514): Protein of unknown function C-terminus (DUF2451)
56 ZYXsuppressor21.0000DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
LIM (PF00412, IPR001781, SM00132): LIM domain
DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)

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