Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SLC25A37, MLF2 (from a repository: Tue Feb 6 20:35:48 2018)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)45
The number (and %) of the onco-proteins12 (26.67 %)
The number (and %) of the tumor suppressors4 (8.89 %)
Total number of binary PPIs (saturation %)182 (18.38 %)
The number (and %) of affected PPIs43 (23.63 %)
The number of possible different fusions6
PPI diameter4
PPI radius2
The average degree of PPI7.378
Assortativity coefficient-0.1999
The network average Clustering coefficient0.521
The number (and %) of a zero Clustering coefficients2 (4.44 %)
The number (and %) of a zero Betweenness Centrality7 (15.56 %)


List of the fusions

PPI for parental proteins: SLC25A37,MLF2 All fusions
Proteins found in more fusions UBC (see 1 fusions); BAG3 (see 4 fusions); HSP90AA1 (see 2 fusions); STUB1 (see 1 fusions); BAG2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 SLC25A37parental protein100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
2 MLF2parental protein420.1361132.343Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
3 ABCD3interactor50.5003.733ABC_membrane_2 (PF06472, IPR010509): ABC transporter transmembrane region 2
ABC_tran (PF00005, IPR003439): ABC transporter
4 AIFM1oncoprotein50.5004.000Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
AIF-MLS (PF14962, IPR032773): Mitochondria Localisation Sequence
5 BAG1oncoprotein70.6672.802BAG (PF02179, IPR003103, SM00264): BAG domain
Presenilin (PF01080, IPR001108): Presenilin
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
6 BAG2protein found in more fusions130.42427.797IncA (PF04156, IPR007285): IncA protein
Mnd1 (PF03962, IPR005647): Mnd1 family
ParD_antitoxin (PF03693, IPR022789): Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH
7 BAG3oncoprotein130.40927.058BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
8 BAG4interactor90.44430.238BAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
9 CCDC8interactor100.27846.463Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
10 CIAO1interactor40.6671.667WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
11 DNAJB1suppressor100.40016.489DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
12 DNAJB4suppressor80.4649.556DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
13 DNAJB6interactor140.28650.300DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
14 ELAVL1oncoprotein80.19093.700RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
15 FAM96Ainteractor30.6670.667DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
16 FAM96Binteractor40.6671.167DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
17 FBXW11interactor80.52422.137WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
18 GCN1interactor60.4008.063Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
19 GPRASP2interactor21.0000Arm_2 (PF04826, IPR006911): Armadillo-like
DUF3020 (PF11223, IPR021386): Protein of unknown function (DUF3020)
PH_4 (PF15404): Pleckstrin homology domain
20 HDAC11interactor50.5003.167Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
21 HERC2interactor50.8330.786ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
22 HSP90AA1oncoprotein130.34830.532HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
23 HSPA6interactor60.4004.252HSP70 (PF00012, IPR013126): Hsp70 protein
24 HSPB2interactor200Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
25 INPPL1oncoprotein90.36120.494Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
26 KIF15interactor40.8330.667Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
STE (PF02200, IPR003120, SM00424): STE like transcription factor
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
FlxA (PF14282, IPR025577): FlxA-like protein
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
27 KRASoncoprotein60.60014.351Ras (PF00071, IPR001806, SM00173): Ras family
28 LRBAoncoprotein50.5003.567Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
DUF1088 (PF06469, IPR010508): Domain of Unknown Function (DUF1088)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
DUF4704 (PF15787, IPR031570): Domain of unknown function (DUF4704)
29 MMS19interactor60.4677.805DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
30 MOV10interactor90.33319.900AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
31 NANOGinteractor41.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
32 NXF1interactor130.37929.467NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
33 PMVKinteractor21.0000P-mevalo_kinase (PF04275, IPR005919): Phosphomevalonate kinase
34 POP1interactor60.6003.000POP1 (PF06978, IPR009723): Ribonucleases P/MRP protein subunit POP1
POPLD (PF08170, IPR012590): POPLD (NUC188) domain
35 POU5F1oncoprotein50.8330.500Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
36 PRKAA2suppressor30.6670.286Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
37 RGS20interactor21.0000RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
38 RPP30interactor50.7002.167RNase_P_p30 (PF01876, IPR002738): RNase P subunit p30
39 SOX2oncoprotein130.31841.078HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
40 SRP72interactor31.0000BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
SRP_TPR_like (PF17004, IPR031545): Putative TPR-like repeat
41 STIP1interactor80.39329.178TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
42 STUB1suppressor130.53015.213U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
43 UBCprotein found in more fusions120.38223.088ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
44 USP19interactor60.5335.400CS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
45 XPO1interactor110.30956.926CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

B a c k    t o    T o p ⇑