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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TACO1, NMT2 (from a repository: Mon Sep 16 16:23:52 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins9 (32.14 %)
The number (and %) of the tumor suppressors3 (10.71 %)
Total number of binary PPIs (saturation %)63 (16.67 %)
The number (and %) of affected PPIs27 (42.86 %)
The number of possible different fusions7
PPI diameter4
PPI radius2
The average degree of PPI3.571
Assortativity coefficient-0.4030
The network average Clustering coefficient0.370
The number (and %) of a zero Clustering coefficients11 (39.29 %)
The number (and %) of a zero Betweenness Centrality14 (50.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NMT2,TACO1 All fusions
Proteins found in more fusions ZNRF1 (see 1 fusions); APP (see 5 fusions); SAT1 (see 6 fusions); TP53 (see 3 fusions); PRPS2 (see 2 fusions); GAPDH (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NMT2parental protein190.094425.167NMT (PF01233, IPR022676): Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
NMT_C (PF02799, IPR022677): Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
2 TACO1parental protein80.036210.000Transcrip_reg (PF01709, IPR002876): Transcriptional regulator
3 ANXA4interactor21.0000Annexin (PF00191, IPR018502, SM00335): Annexin
4 ANXA7suppressor40.50012.533Annexin (PF00191, IPR018502, SM00335): Annexin
5 APPprotein found in more fusions70.333141.367APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 BCL2oncoprotein50.8330.667Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
7 CAB39interactor100Mo25 (PF08569, IPR013878): Mo25-like
8 CSNK2Binteractor50.6673.333CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
9 FAM84Binteractor100LRAT (PF04970, IPR007053): Lecithin retinol acyltransferase
10 FBXO17interactor100FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
11 FOXD4interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
12 GAPDHoncoprotein70.33347.833Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
13 GFOD1interactor200GFO_IDH_MocA (PF01408, IPR000683): Oxidoreductase family, NAD-binding Rossmann fold
GFO_IDH_MocA_C (PF02894, IPR004104): Oxidoreductase family, C-terminal alpha/beta domain
14 HPDLinteractor100Glyoxalase_3 (PF13468, IPR025870): Glyoxalase-like domain
Glyoxalase_4 (PF13669): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
15 ODF3L2interactor100SHIPPO-rpt (PF07004, IPR010736): Sperm-tail PG-rich repeat
16 PPP1CConcoprotein50.6007.667Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
17 PRKCZinteractor31.0000PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
18 PRPS1oncoprotein31.0000Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain
19 PRPS2protein found in more fusions31.0000Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain
20 SAT1protein found in more fusions309.500Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
21 SEC22Binteractor2010.000Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain
22 SLC9A3R2interactor100EBP50_C (PF09007, IPR015098): EBP50, C-terminal
GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
23 SMN1interactor50.6676.533SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
24 TGFB1suppressor21.0000TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
25 TK1oncoprotein50.6674.033TK (PF00265, IPR001267, SM00203): Thymidine kinase
26 TMED9interactor30.33332.000EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
27 TP53suppressor110.28975.367DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
28 ZNRF1protein found in more fusions200zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
RNF220 (PF15926, IPR031824): E3 ubiquitin-protein ligase RNF220

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