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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins JPT1, CCNG2 (from a repository: Sun Aug 11 18:07:02 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins8 (33.33 %)
The number (and %) of the tumor suppressors3 (12.50 %)
Total number of binary PPIs (saturation %)35 (12.68 %)
The number (and %) of affected PPIs22 (62.86 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI2.500
Assortativity coefficient-0.4515
The network average Clustering coefficient0.437
The number (and %) of a zero Clustering coefficients10 (41.67 %)
The number (and %) of a zero Betweenness Centrality19 (79.17 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CCNG2,JPT1 All fusions
Proteins found in more fusions HSPB1 (see 1 fusions); TRIM28 (see 1 fusions); FAM208B (see 2 fusions); SFPQ (see 6 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CCNG2parental protein80.107199.000Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
2 JPT1parental protein140.044389.000JUPITER (PF17054): Microtubule-Associated protein Jupiter
3 ARHGAP44interactor100BAR (PF03114, IPR004148, SM00721): BAR domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
4 CFL1interactor21.0000Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
5 COTL1oncoprotein21.0000Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
6 CPLX1interactor100Synaphin (PF05835, IPR008849): Synaphin protein
7 EFHC2interactor100DUF1126 (PF06565, IPR010554): DUF1126 PH-like domain
EF-hand_6 (PF13405, IPR002048): EF-hand domain
8 FAM208Bprotein found in more fusions200DUF3699 (PF12480, IPR022168): Protein of unknown function (DUF3699)
DUF3715 (PF12509, IPR022188): Protein of unknown function (DUF3715)
9 HSPB1oncoprotein31.0000HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
10 KPNA2interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
11 NRIP2interactor100Asp_protease (PF09668, IPR019103): Aspartyl protease
12 PLIN3interactor200Perilipin (PF03036, IPR004279): Perilipin family
13 PMPCBinteractor100Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
14 PPP2CAsuppressor40.333241.000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
15 PPP2R5Binteractor21.0000B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
16 PPP2R5Csuppressor21.0000B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
DUF1616 (PF07760, IPR011674): Protein of unknown function (DUF1616)
17 SEPT9oncoprotein100Septin (PF00735, IPR000038): Septin
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
18 SFPQoncoprotein31.0000GRP (PF07172, IPR010800): Glycine rich protein family
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
NOPS (PF08075, IPR012975): NOPS (NUC059) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
19 SKP1oncoprotein21.0000Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
20 SKP2suppressor21.0000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_2 (PF07723, IPR013101): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
21 SNCGoncoprotein100Synuclein (PF01387, IPR001058): Synuclein
22 STMN1interactor30.6671.000Stathmin (PF00836, IPR000956): Stathmin family
23 TRIM28protein found in more fusions31.0000ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
24 UNKinteractor30.333252.000MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain

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