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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins JPT1, COL1A2 (from a repository: Thu Aug 1 01:46:02 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins12 (36.36 %)
The number (and %) of the tumor suppressors2 (6.06 %)
Total number of binary PPIs (saturation %)59 (11.17 %)
The number (and %) of affected PPIs31 (52.54 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI2.909
Assortativity coefficient-0.4535
The network average Clustering coefficient0.278
The number (and %) of a zero Clustering coefficients17 (51.52 %)
The number (and %) of a zero Betweenness Centrality19 (57.58 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: COL1A2,JPT1 All fusions
Proteins found in more fusions COL1A1 (see 14 fusions); HSPB1 (see 1 fusions); TRIM28 (see 1 fusions); UBQLN1 (see 2 fusions); SFPQ (see 6 fusions); COL1A1/PDGFB (see 20 fusions); COL1A2/COL1A1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 COL1A2parental protein170.037611.000COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
2 JPT1parental protein140.044414.833JUPITER (PF17054): Microtubule-Associated protein Jupiter
3 ARHGAP44interactor100BAR (PF03114, IPR004148, SM00721): BAR domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
4 CAMKMTinteractor21.0000Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
5 CDKN2AIPinteractor100XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD
6 CFL1interactor30.33353.167Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
7 COL1A1oncoprotein60.4006.000COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
EKLF_TAD1 (PF16832, IPR031786): Erythroid krueppel-like transcription factor, transactivation 1
8 COMTinteractor100Methyltransf_3 (PF01596, IPR002935): O-methyltransferase
9 COTL1oncoprotein21.0000Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
10 CPLX1interactor2043.333Synaphin (PF05835, IPR008849): Synaphin protein
11 ERAL1interactor21.0000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
KH_1 (PF00013, IPR004088, SM00322): KH domain
12 FBXW7suppressor200Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
13 HSPB1oncoprotein31.0000HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
14 KPNA2interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
15 LIG4interactor21.0000APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
16 MYOCinteractor200IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
17 PAN2interactor40175.333RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
18 PDGFAoncoprotein21.0000PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
SyrA (PF11089, IPR024239): Exopolysaccharide production repressor
19 PDGFBoncoprotein31.0000PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
20 PLIN3interactor200Perilipin (PF03036, IPR004279): Perilipin family
21 PMPCBinteractor100Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
22 RAB5Aoncoprotein2035.333Ras (PF00071, IPR001806, SM00173): Ras family
23 SEPT9oncoprotein100Septin (PF00735, IPR000038): Septin
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
24 SERPINB5suppressor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
25 SFPQoncoprotein40.33328.167GRP (PF07172, IPR010800): Glycine rich protein family
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
NOPS (PF08075, IPR012975): NOPS (NUC059) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
26 SGTAinteractor2050.167TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_17 (PF13431): Tetratricopeptide repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
27 SHBGoncoprotein200Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
28 SNCGoncoprotein100Synuclein (PF01387, IPR001058): Synuclein
29 STMN1interactor50.20093.333Stathmin (PF00836, IPR000956): Stathmin family
30 TRIM28protein found in more fusions40.33361.333ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
31 UBQLN1protein found in more fusions4084.167Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
32 UNKinteractor40.16778.167MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
33 ZWINTinteractor40.33365.667Zwint (PF15556, IPR029092): ZW10 interactor

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