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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GKN1, HSD17B12 (from a repository: Thu Dec 5 18:02:25 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)45
The number (and %) of the onco-proteins11 (24.44 %)
The number (and %) of the tumor suppressors2 (4.44 %)
Total number of binary PPIs (saturation %)255 (25.76 %)
The number (and %) of affected PPIs43 (16.86 %)
The number of possible different fusions5
PPI diameter4
PPI radius2
The average degree of PPI10.889
Assortativity coefficient-0.0651
The network average Clustering coefficient0.554
The number (and %) of a zero Clustering coefficients3 (6.67 %)
The number (and %) of a zero Betweenness Centrality5 (11.11 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GKN1,HSD17B12 All fusions
Proteins found in more fusions UBQLN1 (see 2 fusions); COPB1 (see 2 fusions); UBC (see 1 fusions); EGFR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GKN1parental protein100BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
2 HSD17B12parental protein420.232644.016adh_short (PF00106, IPR002198): short chain dehydrogenase
3 ADRB2interactor100.6673.3827tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 AFG3L2interactor120.6826.991AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
FtsH_ext (PF06480, IPR011546): FtsH Extracellular
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
TniB (PF05621, IPR008868): Bacterial TniB protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
5 AHSA1interactor80.6076.166Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
6 ATP1A1interactor240.43872.615Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
7 ATP1B1interactor70.7621.880Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
8 ATP5C1interactor130.57714.280ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
9 CDC27oncoprotein4086.667TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
10 CERS2interactor60.6002.583PDR_CDR (PF06422, IPR010929): CDR ABC transporter
TRAM1 (PF08390, IPR013599): TRAM1-like protein
TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
11 CLN3interactor90.8061.395CLN3 (PF02487, IPR003492): CLN3 protein
12 COPB1protein found in more fusions60.7000.708Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Coatamer_beta_C (PF07718, IPR011710): Coatomer beta C-terminal region
Coatomer_b_Cpla (PF14806, IPR029446): Coatomer beta subunit appendage platform
13 CYC1interactor130.6798.930Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
14 EGFRoncoprotein190.42545.954Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
15 ELOVL1interactor40.8330.333ELO (PF01151, IPR002076): GNS1/SUR4 family
16 ETFAinteractor60.7331.594ETF (PF01012, IPR014730, SM00893): Electron transfer flavoprotein domain
ETF_alpha (PF00766, IPR014731): Electron transfer flavoprotein FAD-binding domain
17 FASNinteractor41.0000Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ketoacyl-synt (PF00109, IPR014030): Beta-ketoacyl synthase, N-terminal domain
Ketoacyl-synt_C (PF02801, IPR014031): Beta-ketoacyl synthase, C-terminal domain
KR (PF08659, IPR013968, SM00130): KR domain
L27 (PF02828, IPR014775, SM00569): L27 domain
Methyltransf_12 (PF08242, IPR013217): Methyltransferase domain
PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site
Thioesterase (PF00975, IPR001031): Thioesterase domain
YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
PS-DH (PF14765, IPR020807): Polyketide synthase dehydratase
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
18 HDAC11interactor100Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
19 HECW2interactor50.50025.743C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
20 HSP90B1suppressor90.5836.872CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
21 IPO5interactor61.0000HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
22 MMS19interactor60.8000.736DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
23 NTRK1oncoprotein260.307247.211I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
24 OTUB1interactor80.5715.304Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
25 PHBsuppressor140.48420.619Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
26 PPP2R1Aoncoprotein120.63610.281TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
27 RAB1Aoncoprotein170.47831.143Ras (PF00071, IPR001806, SM00173): Ras family
28 RAB1Boncoprotein140.53816.273Ras (PF00071, IPR001806, SM00173): Ras family
29 RNF2interactor130.34826.541zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
30 RPL36interactor30.6670.286Ribosomal_L36e (PF01158, IPR000509): Ribosomal protein L36e
31 RPN1oncoprotein250.39788.964Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
32 SCDinteractor70.4763.231MerC (PF03203, IPR004891): MerC mercury resistance protein
33 SLC25A3interactor170.45634.453Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
34 SSR3interactor80.5715.340TRAP-gamma (PF07074, IPR009779): Translocon-associated protein, gamma subunit (TRAP-gamma)
35 TCTN2interactor90.4727.774DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
36 TCTN3interactor110.40019.588DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
37 TECRinteractor180.40562.613Steroid_dh (PF02544, IPR001104): 3-oxo-5-alpha-steroid 4-dehydrogenase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
38 TMCO1interactor130.62810.192DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
39 TMED2interactor60.8001.056EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
40 TOMM22interactor80.5714.979Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
41 UBCprotein found in more fusions140.47418.806ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
42 UBL4Ainteractor120.43921.272ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
43 UBQLN1protein found in more fusions60.8000.850Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
44 UQCRC2oncoprotein220.40368.381Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
45 WARSinteractor21.0000tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain

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