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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HSD17B12, DBI (from a repository: Tue Aug 13 11:40:48 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)61
The number (and %) of the onco-proteins13 (21.31 %)
The number (and %) of the tumor suppressors4 (6.56 %)
Total number of binary PPIs (saturation %)304 (16.61 %)
The number (and %) of affected PPIs59 (19.41 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI9.541
Assortativity coefficient0.0848
The network average Clustering coefficient0.460
The number (and %) of a zero Clustering coefficients5 (8.20 %)
The number (and %) of a zero Betweenness Centrality7 (11.48 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HSD17B12,DBI All fusions
Proteins found in more fusions UBQLN1 (see 2 fusions); LGALS3 (see 2 fusions); FASN (see 1 fusions); EGFR (see 2 fusions); COPB1 (see 2 fusions); UBC (see 7 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HSD17B12parental protein420.232846.329adh_short (PF00106, IPR002198): short chain dehydrogenase
2 DBIparental protein170.066662.622ACBP (PF00887, IPR000582): Acyl CoA binding protein
JmjN (PF02375, IPR003349, SM00545): jmjN domain
3 ADRB2interactor110.53379.1587tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 AFG3L2interactor120.6827.107AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
FtsH_ext (PF06480, IPR011546): FtsH Extracellular
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
TniB (PF05621, IPR008868): Bacterial TniB protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
5 AHSA1interactor100.400111.212Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
6 ATP1A1interactor250.413198.774Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
7 ATP1B1interactor70.7621.640Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
8 ATP5C1interactor140.51653.262ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
9 CERS2interactor60.6003.254PDR_CDR (PF06422, IPR010929): CDR ABC transporter
TRAM1 (PF08390, IPR013599): TRAM1-like protein
TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
10 CLN3interactor90.8061.395CLN3 (PF02487, IPR003492): CLN3 protein
11 COPB1protein found in more fusions60.7001.495Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Coatamer_beta_C (PF07718, IPR011710): Coatomer beta C-terminal region
Coatomer_b_Cpla (PF14806, IPR029446): Coatomer beta subunit appendage platform
12 CRIP1interactor40.6673.922LIM (PF00412, IPR001781, SM00132): LIM domain
13 CYC1interactor130.6798.640Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
14 DUSP23interactor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family
PTPlike_phytase (PF14566): Inositol hexakisphosphate
15 EGFRoncoprotein200.398131.919Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
16 ELOVL1interactor40.8330.333ELO (PF01151, IPR002076): GNS1/SUR4 family
17 ETFAinteractor70.52436.295ETF (PF01012, IPR014730, SM00893): Electron transfer flavoprotein domain
ETF_alpha (PF00766, IPR014731): Electron transfer flavoprotein FAD-binding domain
18 FASNprotein found in more fusions41.0000Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ketoacyl-synt (PF00109, IPR014030): Beta-ketoacyl synthase, N-terminal domain
Ketoacyl-synt_C (PF02801, IPR014031): Beta-ketoacyl synthase, C-terminal domain
KR (PF08659, IPR013968, SM00130): KR domain
L27 (PF02828, IPR014775, SM00569): L27 domain
Methyltransf_12 (PF08242, IPR013217): Methyltransferase domain
PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site
Thioesterase (PF00975, IPR001031): Thioesterase domain
YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
PS-DH (PF14765, IPR020807): Polyketide synthase dehydratase
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
19 GSK3Bsuppressor40.33325.463Pkinase (PF00069, IPR000719): Protein kinase domain
20 HDAC11interactor100Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
21 HECW2interactor50.50069.622C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
22 HSP90B1suppressor90.5837.716CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
23 HSPE1interactor30.33319.377Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
24 IPO5interactor70.81010.953HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
25 LAMTOR5interactor100LAMTOR5 (PF16672, IPR024135): Ragulator complex protein LAMTOR5
26 LGALS3oncoprotein80.381186.361Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
27 MAP1LC3Binteractor30.33322.550Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
28 MMS19interactor60.8000.902DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
29 NIPSNAP1interactor40.16779.168NIPSNAP (PF07978, IPR012577): NIPSNAP
30 NSFL1Cinteractor40.33365.839SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
UBA_4 (PF14555): UBA-like domain
31 NTRK1oncoprotein280.274372.317I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
32 OTUB1interactor80.5718.238Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
33 PCDH1interactor100Cadherin_2 (PF08266, IPR013164): Cadherin-like
Protocadherin (PF08374, IPR013585): Protocadherin
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
RGCC (PF15151, IPR029252): Response gene to complement 32 protein family
Cadherin_3 (PF16184): Cadherin-like
34 PHBsuppressor140.48433.977Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
35 PPP2R1Aoncoprotein120.63619.364TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
36 RAB1Aoncoprotein170.47840.082Ras (PF00071, IPR001806, SM00173): Ras family
37 RAB1Boncoprotein140.53821.316Ras (PF00071, IPR001806, SM00173): Ras family
38 RAD23Aoncoprotein60.40045.050UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
39 RAD23Bsuppressor60.46773.673K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
40 RNF2interactor130.34842.288zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
41 RPL36interactor30.6670.286Ribosomal_L36e (PF01158, IPR000509): Ribosomal protein L36e
42 RPN1oncoprotein250.397104.636Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
43 SCDinteractor70.4764.248MerC (PF03203, IPR004891): MerC mercury resistance protein
44 SLC25A3interactor170.45637.668Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
45 SLC25A32interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
46 SOD1interactor60.40032.885Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
47 SSR3interactor80.5716.582TRAP-gamma (PF07074, IPR009779): Translocon-associated protein, gamma subunit (TRAP-gamma)
48 TCTN2interactor100.37855.271DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
49 TCTN3interactor130.282138.990DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
50 TECRinteractor180.40574.950Steroid_dh (PF02544, IPR001104): 3-oxo-5-alpha-steroid 4-dehydrogenase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
51 TMCO1interactor130.62811.945DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
52 TMED2interactor60.8001.624EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
53 TMEM132Ainteractor30.33339.691DUF4366 (PF14283, IPR025376): Domain of unknown function (DUF4366)
TMEM132D_N (PF15705, IPR031435): Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
TMEM132D_C (PF15706, IPR031436): Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
TMEM132 (PF16070, IPR031437): Transmembrane protein family 132
54 TOMM22interactor80.5715.104Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
55 UBCprotein found in more fusions190.275365.173ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
56 UBL4Ainteractor120.43935.556ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
57 UBQLN1protein found in more fusions80.57134.220Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
58 UBXN2Ainteractor21.0000SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
59 UQCRC2oncoprotein220.40375.431Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
60 WARSinteractor30.33312.188tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
61 YKT6interactor50.100117.938Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain

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